Alzheimer's Disease Research Center

阿尔茨海默病研究中心

• 批准号: 7121410
• 负责人: LEON J THAL
• 金额: $ 3.86万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7121410
• 关键词: Alzheimer' s disease; amyloid proteins; clinical research; dementia; molecular pathology; neural degeneration; neurofibrillary tangles

DESCRIPTION (provided by applicant): This proposal is for a five-year renewal of the Alzheimer's Disease Research Center (ADRC) at the University of California San Diego in consortium with The Buck Institute. The major goals of the Center over the next five years will be to expand our efforts into studying the conversion from normal aging to dementia through the intermediary step of Mild Cognitive Impairment (MCI) and to study mechanisms of neurodegeneration Projects will focus on functional MRI of the elderly at risk for Alzheimer's disease (Bondi, Project 1), testing of the role of axonal disturbances in Alzheimer's disease (Goldstein, Project 2), and studying the cytoplasmic domain of APP and its interacting proteins in synapse damage (Koo, Project 3). This Center will continue to maintain extremely strong Clinical and Neuropathological Cores. The Clinical Core will continue to longitudinally characterize a cohort of approximately 500 subjects to study early changes in cognition and semantic memory, and to provide other investigators and the San Diego community as a whole with a well characterized clinical cohort of both Caucasian and Hispanic volunteers. The Clinical Core will also recruit subjects and controls to support the special needs of many of the individual projects. The Center will also continue its participation in collaborative projects with other ADCs funded through the NACC or directly from NIA. Subjects will also participate in multi-center drug trials. Data derived from subjects will be used in collaborative research. In addition we will continue to carry out detailed clinicopathological correlations in Alzheimer's disease and other related neurodegenerative diseases: Lewy Body Variant of AD and fronto-temporal dementia. The Neuropath Core has taken a lead role in this endeavor. The Center as a whole will continue to provide brain tissue, plasma, serum, DNA, and cerebrospinal fluid to investigators upon request. The ADRC provides a setting to facilitate research training of investigators and will transfer information to the professional and lay communities through our miniresidency program, conferences and other educational activities. The Data Management and Biostatistics Core will continue to provide statistical design and analysis services to ADRC investigators, prepare the minimum data set for submission to the NACC, as well as coordinate the entry, quality control, management and analysis of data generated by the Clinical and Neuropathology Cores.

描述（由申请人提供）：该提案是针对加利福尼亚大学圣地亚哥分校与巴克研究所（Buck Institute）在加利福尼亚大学圣地亚哥分校的阿尔茨海默氏病研究中心（ADRC）的五年更新。在接下来的五年中，该中心的主要目标将是扩大我们的努力，通过轻度认知障碍（MCI）的中介步骤研究从正常衰老到痴呆症的转变（MCI），并研究神经退行性项目项目的机制，将重点介绍老年人的功能性MRI，这将集中在阿尔茨海默氏病风险的老年人（Bondi，Project 1）的风险（BONDI 1），该疾病的疾病，曾经是GOLDSON的一部分，是GOLD的疾病。 2），研究APP的细胞质结构域及其在突触损害中的相互作用蛋白（Koo，项目3）。该中心将继续保持极强的临床和神经病理核心。临床核心将继续纵向表征约500名受试者的队列，以研究认知和语义记忆的早期变化，并为其他研究人员和整个圣地亚哥社区提供具有良好特征的高加索人和西班牙志愿者的临床人群。临床核心还将招募受试者和控件，以支持许多单个项目的特殊需求。该中心还将继续与通过NACC或直接从NIA资助的其他ADC参与合作项目。受试者还将参加多中心药物试验。从主题中得出的数据将用于协作研究。此外，我们将继续在阿尔茨海默氏病和其他相关的神经退行性疾病中进行详细的临床病理相关性：AD和额叶痴呆的Lewy身体变体。神经病患者核心在这项努力中发挥了领先作用。整个中心将继续根据要求向研究人员提供脑组织，血浆，血清，DNA和脑脊液。 ADRC提供了一个促进研究人员研究培训的设置，并将通过我们的小型计划，会议和其他教育活动将信息转移到专业和外行社区。数据管理和生物统计学 Core将继续向ADRC研究人员提供统计设计和分析服务，准备提交给NACC的最低数据集，并协调临床和神经病理核心产生的数据的进入，质量控制，管理和分析。