Longitudinal Analysis of Silicone Hydrogel (LASH) Study

硅水凝胶 (LASH) 纵向分析研究

• 批准号: 6864417
• 负责人: LORETTA B SZCZOTKA-FLYNN
• 金额: $ 17.45万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-03-01 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6864417
• 关键词: clinical research; complement pathway regulation; contact lens; cornea; enzyme linked immunosorbent assay; epidemiology; eye disorder diagnosis; eye infections; human subject; hypoxia; immunocytochemistry; inflammation; longitudinal human study; organosilicon compound; patient oriented research; western blottings

DESCRIPTION (provided by applicant): This K23 project serves two purposes: 1) It provides research career development and training for Loretta Szczotka, O.D., M.S., who has made a commitment to focus on patient-oriented research, to launch an independent career in clinical research. 2) It provides her with the knowledge and research skills necessary to translate the findings of previous studies performed by investigators at Case Western Reserve University (CWRU) into the proposed clinical research project, the Longitudinal Analysis of Silicone Hydrogel (LASH) Contact Lens Study. The five-year program, will to lead to 1) the Ph.D. in Epidemiology from the Department of Epidemiology and Biostatistics at CWRU, 2) additional training in the relevant basic and clinical science discipline of ocular immunology, and 3) a better scientific understanding of the factors and mechanisms of inflammatory and mechanical complications of silicone hydrogel continuous wear (CW) contact lens use. The LASH Contact Lens Study, and her training in epidemiology, will allow the candidate to enhance her independent research skills in an area of her clinical expertise, by serving as principal investigator in all phases of the study design, implementation, data management, and data analysis under the guidance of outstanding scientist-mentors in the fields of biometrics, immunology, and ophthalmology. The LASH Contact Lens Study will test the hypothesis that complement activation and regulation coupled with bacterial contamination of lenses and the ocular surfaces are risk factors for contact lens associated inflammatory complications. Additionally, this project will test the hypothesis that novel quantitative central and peripheral corneal shape descriptors, measured by corneal topography, are associated with mechanical complications during long term wear of silicone hydrogel lenses. 224 patients will be enrolled and followed for three years in this longitudinal cohort study.

描述（由申请人提供）：该 K23 项目有两个目的： 1) 为 Loretta Szczotka, O.D., M.S. 提供研究职业发展和培训，她致力于专注于以患者为导向的研究，在临床研究。 2) 它为她提供了必要的知识和研究技能，将凯斯西储大学 (CWRU) 研究人员之前进行的研究结果转化为拟议的临床研究项目，即硅水凝胶 (LASH) 隐形眼镜研究的纵向分析。这个为期五年的计划将导致 1) 博士学位。 CWRU 流行病学和生物统计学系流行病学博士学位，2) 眼部免疫学相关基础和临床科学学科的额外培训，以及 3) 对硅水凝胶连续佩戴的炎症和机械并发症的因素和机制有更好的科学理解(CW) 隐形眼镜的使用。 LASH 隐形眼镜研究以及她在流行病学方面的培训将使候选人能够通过在研究设计、实施、数据管理和数据的所有阶段担任首席研究员来增强她在临床专业领域的独立研究技能。在生物识别学、免疫学和眼科领域杰出科学家导师的指导下进行分析。 LASH 隐形眼镜研究将检验以下假设：补体激活和调节以及镜片和眼表面的细菌污染是隐形眼镜相关炎症并发症的危险因素。 此外，该项目将测试以下假设：通过角膜地形图测量的新型定量中央和周边角膜形状描述符与长期佩戴硅水凝胶镜片期间的机械并发症相关。 这项纵向队列研究将招募 224 名患者并进行为期三年的随访。