Simutaneous fMRI and EEG of Epileptogenic Brain Regions

癫痫脑区的同步功能磁共振成像和脑电图

• 批准号: 6909995
• 负责人: JOHN M STERN
• 金额: $ 16.14万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6909995
• 关键词: bioimaging /biomedical imaging; brain circulation; brain electrical activity; brain imaging /visualization /scanning; brain metabolism; clinical research; computer simulation; diagnosis design /evaluation; electroencephalography; epilepsy; functional magnetic resonance imaging; histopathology; human subject; patient oriented research

DESCRIPTION (provided by applicant): The proposed study will provide the candidate a five year opportunity to further develop his research skills and to focus his efforts on the functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) research that he has conducted with his sponsors since 1995. The study's ultimate goal is to evaluate simultaneous fMRI and EEG (fMRI/EEG) recordings as a means to accurately localize primary epileptogenic regions, the regions responsible for seizures. The importance of this rests in the current absence of any technique for accurate epileptogenic region localization, and the potential clinical benefit of such localization for the hundreds of thousands of people in the United States alone whose seizures are refractory to current treatments. fMRI/EEG is a new technique in human brain mapping that depicts highly localized cerebrovascular changes as occur during epileptic discharges on EEG. Because fMRI/EEG is sensitive to metabolic characteristics, it potentially may distinguish the primary epileptogenic region through its metabolic difference from other regions. Our approach will employ statistical comparisons between fMRI/EEG results and the results of multiple other assessments available to our epilepsy surgery program. These assessments include scalp EEG, intracranial EEG, EEG source modeling, magnetoencephalography, tissue pathology, epilepsy surgery evaluation outcome, and epilepsy surgery outcome. Overall, the study capitalizes upon an especially strong environment with established infrastructures in clinical epilepsy, epilepsy research and human brain mapping. The candidate's academic position spans UCLA's Brain Mapping Center and Seizure Disorder Center, and the sponsors are the respective directors of the fMRI and epilepsy programs. With a background of graduate research in nuclear magnetic resonance and fellowship training in clinical epilepsy, the candidate is developing a career in clinical research focused on the application of human brain mapping techniques toward epilepsy.

描述（由申请人提供）：拟议的研究将为候选人提供五年的机会，以进一步发展他的研究技能，并将其精力集中在他与他的同事进行的功能性磁共振成像（fMRI）和脑电图（EEG）研究上。自 1995 年以来一直是赞助商。该研究的最终目标是评估同步功能磁共振成像和脑电图 (fMRI/EEG) 记录，作为准确定位原发性癫痫区域（负责癫痫发作的区域）的一种手段。其重要性在于，目前还没有任何精确的癫痫发作区域定位技术，而这种定位对于仅在美国就数十万目前治疗难以治愈的癫痫患者来说具有潜在的临床益处。功能磁共振成像/脑电图是人类大脑绘图的一项新技术，它描绘了脑电图癫痫放电期间发生的高度局部脑血管变化。由于功能磁共振成像/脑电图对代谢特征敏感，因此它可能通过其与其他区域的代谢差异来区分原发癫痫区域。我们的方法将采用功能磁共振成像/脑电图结果与我们癫痫手术项目可用的多项其他评估结果之间的统计比较。这些评估包括头皮脑电图、颅内脑电图、脑电图源建模、脑磁图、组织病理学、癫痫手术评估结果和癫痫手术结果。总体而言，该研究利用了在临床癫痫、癫痫研究和人脑图谱方面已建立的基础设施的强大环境。候选人的学术职位横跨加州大学洛杉矶分校的脑图谱中心和癫痫症中心，赞助者分别是功能磁共振成像和癫痫项目的主任。凭借核磁共振研究生研究和临床癫痫研究培训的背景，该候选人正在从事临床研究，重点关注人脑图谱技术在癫痫方面的应用。