Alzheimer's Disease Center Core

阿尔茨海默病中心核心

• 批准号: 6928022
• 负责人: JOHN Q. TROJANOWSKI
• 金额: $ 130.35万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-09-30 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6928022
• 关键词: Alzheimer' s disease; biomedical facility; dementia

The motivation to pursue support for research on Alzheimer's disease (AD) and related disorders at the University of Pennsylvania Medical Center (UPMC) through a National Institute on Aging (NIA) research on these neurodegenerative diseases. Since it was established in 1991, the Penn ADCC has contributed to dramatic expansion in basic and clinical research on AD and related disorders at UPMC by providing leadership, education and core support to enhance and stimulate investigations into the etiology, pathogenesis, diagnosis, treatment and prevention of these neurodegenerative diseases. Commensurate with this growth over the past decade, Penn is recognized as an international leader in research on AD. Thus, the mission of the Penn ADCC in the next funding cycle will continue to be to: increase understanding of an research on AD at and beyond Penn, foster interactions between ADCC and other AD Centers (ADCs) and/or institutions, increase interactions with the National Alzheimer Coordinating Center (NAC), participate in NACC sponsored ADC collaborative studies, respond to NIA initiatives on AD and related disorders. The substantial progress of the Penn ADCC in this funding period indicates that it will continue to accomplish its mission in the renewal period. To do this, this competing renewal application describes how the Penn ADCC will accomplish its goals with: 1) An Administrative Core to oversee and direct the activities of the ADCC as well as interactions with NIA, NACC, ADCs and women and minorities and including biological samples, for research; 3) A Latino Satellite Clinic to recruit urban Latinos into AD and control cohorts for study; 4) A Neuropathology Core to bank bodily fluids and tissues from ADCC subjects for diagnostic studies and research; 5) An Education and Information Transfer Core to foster interest in and awareness of AD and the activities of the Penn ADCC, as well as all aspects of research on AD and related disorders; 6) Pilots to stimulates novel lines of AD research that are likely to continue as funded research projects. In sum, the Penn ADCC will continue to increase understanding and research on AD and related disorders nationally and internationally.

通过国家衰老研究所（NIA）研究这些神经退行性疾病的研究，宾夕法尼亚大学医学中心（UPMC）寻求支持阿尔茨海默氏病（AD）和相关疾病的研究的动机。自1991年成立以来，Penn ADCC通过提供领导力，教育和核心支持来增强和刺激对这些神经性疾病的病因，发病机理，诊断，治疗和预防这些神经性疾病的研究，从而有助于UPMC的AD和相关疾病的基础和临床研究的巨大扩展。在过去十年中，宾夕法尼亚州被认为是AD研究的国际领导者。因此，宾夕法尼亚州ADCC在下一个资金周期中的使命将继续是：提高对宾夕法尼亚州和其他广告范围内的广告研究的理解，ADCC与其他AD中心（ADC）和/或机构之间的相互作用，增加与国家阿尔茨海默氏症协调中心（NAC）（NAC）的相互作用，参与NACC Spossing ADC ADC的协作，并响应了ADC的协作，并响应了AD ADIA，并响应了AD ADIA，并参与了ADIA的相关性。 Penn ADCC在此资金期间的实质进展表明，它将在续签期间继续完成其任务。为此，这种竞争性的续约应用程序描述了Penn ADCC将如何实现其目标：1）管理核心，以监督和指导ADCC的活动以及与NIA，NACC，NACC，ADC，妇女和少数民族以及包括生物样品在内的互动，以进行研究； 3）一家拉丁裔卫星诊所，将城市拉丁裔招募到AD和控制同伙进行研究； 4）来自ADCC受试者的银行体液和组织的神经病理学核心用于诊断研究和研究； 5）教育和信息转移核心，以促进对AD和Penn ADCC活动的兴趣和意识，以及有关AD和相关疾病的研究的各个方面； 6）飞行员刺激可能继续作为资助的研究项目继续进行的新型广告研究线。总而言之，宾夕法尼亚州ADCC将继续在国内和国际上增加对广告和相关疾病的理解和研究。