CELLULAR MECHANISMS OF NEUROPLASTICITY IN STROKE NEUROREHABILITATION

中风神经康复中神经可塑性的细胞机制

• 批准号: 7171432
• 负责人: THOMAS Hugh MCNEILL
• 金额: $ 8.99万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7171432
• 关键词: clinical research; medical rehabilitation related tag; neural plasticity; rehabilitation; stroke therapy

DESCRIPTION (provided by applicant): Stroke is the leading cause of serious, long-term disability among American adults and places a tremendous burden on both the private 'and public health resources of the nation. Of all impairments that result from stroke, one of the most in need of effective rehabilitation studies is hemiparesis of the upper limb, which significantly impacts functional independence and health of stroke survivors. One approach that has shown promise in rehabilitation of upper limb disabilities is Constraint Induced Movement Therapy (CIMT), which emphasizes repetitive use of the impaired limb using task-specific training, while restricting movement of the better limb. However, the "best practice" strategy for the rehabilitation of upper limb paresis using CIMT is still unclear, and little is known about how critical factors such the focus of therapy (skilled learning vs. motor activity), the intensity and timing of therapy, patient motivation, initial impairment and the neural mechanisms that underlie the recovery process interact to impact the effectiveness of rehabilitation therapy. In order to make significant advances in the field of stroke rehabilitation we believe that a concerted interdisciplinary approach among the biological, engineering, computer, and clinical sciences will be needed to solve this complex problem. The studies proposed in this planning grant are designed to meet this challenge and will examine the synergy between neural plasticity and treatment strategies that promote the recovery of upper limb motor function after stroke-induced brain injury. Participants include faculty from the biological, behavioral, computational and engineering sciences with expertise in methods encompassing molecular and cell biology, behavioral neuroscience, bioinformatics, computational modeling, virtual environment technology, haptics, biostatistics and physical rehabilitation. The long-term goals of our study are: 1) to broaden our understanding of the key factors that modulate neuroplasticity and the recovery of function after brain injury, 2) build a foundation of interdisciplinary scientific knowledge that can be used in the development of innovative and more effective therapeutic interventions to enhance the health and independence of persons with post-stroke disabilities; and 3) provide an interdisciplinary training opportunity for (basic science and clinical) graduate and post-doctoral students to develop as independent research scientists equipped to work both within and across scientific disciplines.

描述（由申请人提供）： 中风是美国成年人严重、长期残疾的主要原因，给国家的私人和公共卫生资源带来巨大负担。在中风引起的所有损伤中，最需要有效康复研究的损伤之一是上肢偏瘫，它显着影响中风幸存者的功能独立性和健康。约束诱导运动疗法 (CIMT) 是一种在上肢残疾康复方面显示出前景的方法，它强调通过特定任务的训练重复使用受损肢体，同时限制较好肢体的运动。然而，使用 CIMT 康复上肢瘫痪的“最佳实践”策略仍不清楚，并且对于治疗重点（熟练学习与运动活动）、治疗强度和时间等关键因素如何影响患者的健康状况知之甚少。患者动机、初始损伤和康复过程中的神经机制相互作用，影响康复治疗的有效性。 为了在中风康复领域取得重大进展，我们相信需要生物、工程、计算机和临床科学之间采取协调一致的跨学科方法来解决这个复杂的问题。本规划拨款中提出的研究旨在应对这一挑战，并将研究神经可塑性与促进中风引起的脑损伤后上肢运动功能恢复的治疗策略之间的协同作用。参与者包括来自生物、行为、计算和工程科学领域的教师，他们在分子和细胞生物学、行为神经科学、生物信息学、计算建模、虚拟环境技术、触觉、生物统计学和物理康复等方法方面拥有专业知识。我们研究的长期目标是：1）扩大我们对调节神经可塑性和脑损伤后功能恢复的关键因素的理解，2）建立可用于开发创新的跨学科科学知识的基础更有效的治疗干预措施，以增强中风后残疾人的健康和独立性； 3) 为（基础科学和临床）研究生和博士后提供跨学科培训机会，使他们成为能够在科学学科内和跨学科工作的独立研究科学家。