Sensory Processing Deficits in Cannabis Use

大麻使用中的感官处理缺陷

• 批准号: 7037727
• 负责人: PATRICK David SKOSNIK
• 金额: $ 7.58万
• 依托单位: TRUSTEES OF INDIANA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-30 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7037727
• 关键词: auditory stimulus; behavioral /social science research tag; clinical research; drug detection; electroencephalography; evoked potentials; human subject; interview; marijuana abuse; neural information processing; perceptual distortions; personality; psychometrics; psychopharmacology; questionnaires; substance abuse related behavior; visual stimulus

DESCRIPTION (provided by applicant): It is well known that use of the drug cannabis can induce subjective distortions of perception in several sensory modalities. However, few direct examinations of the neural effects of cannabis use on early sensory processing have been undertaken, particularly utilizing novel electrophysiological techniques. The overall aim of the current proposal is to examine whether current cannabis users demonstrate deficits in neural synchronization as measured by electroencephalographic (EEG) entrainment to periodic auditory and visual stimulation. Subjects will passively observe periodic sensory stimuli (auditory click-trains (10, 20, 30, 40, and 50 Hz) and photic flickers (8, 13, 18, 25, and 38 Hz) while EEGs are recorded. The ability of the resulting steady-state potentials to synchronize to the specific frequencies of stimulation will be assessed via EEG power, signal to noise ratio, and intertrial coherence. In addition, EEG synchronization during perceptual binding will be assessed utilizing an induced gamma paradigm (moving dot stimuli using Random Dot Kinetograms). Several clinical interviews and psychometric questionnaires will also be administered in order to determine possible relationships between EEG brain measures and the perceptual correlates of cannabis use. It is hypothesized that during the entrainment paradigms cannabis users will exhibit decreased EEG power, signal to noise ratio, and intertrial coherence at the frequencies of stimulation across sensory modalities. It is also predicted that during the induced EEG paradigm, cannabis users will exhibit decreased gamma-band (~ 40 Hz) activity during the perception of coherent moving dots. It is hypothesized that these deficits in EEG neural synchronization will correlate with psychometric measures such as schizotypal personality and perceptual aberration, as well as urinary measures of cannabis metabolites. Taken together, this data may serve to elucidate whether the known cognitive dysfunction observed in cannabis use is in part related to disturbances in early sensory information processing and/or neural synchronization.

描述（由申请人提供）：众所周知，大麻药物的使用会导致多种感觉方式的主观感知扭曲。然而，很少有人直接研究大麻使用对早期感觉处理的神经影响，特别是利用新颖的电生理学技术。当前提案的总体目标是检查当前大麻使用者是否表现出神经同步缺陷，这是通过脑电图（EEG）夹带周期性听觉和视觉刺激来测量的。在记录脑电图时，受试者将被动地观察周期性感觉刺激（听觉咔哒声（10、20、30、40 和 50 Hz）和光闪烁（8、13、18、25 和 38 Hz）。与特定刺激频率同步的稳态电位将通过脑电图功率、信噪比和试间相干性进行评估。此外，还将利用诱导伽玛范式（使用随机点运动图移动点刺激）来评估感知结合期间的脑电图同步性，以确定脑电图大脑测量值与感知相关性之间可能的关系。据推测，在夹带范式中，大麻使用者将表现出脑电图功率、信噪比和跨感官刺激频率的间质一致性下降。还预测，在诱导脑电图范式中，大麻使用者在感知相干移动点期间将表现出伽玛波段（~ 40 Hz）活动减少。据推测，脑电图神经同步的这些缺陷将与精神分裂症人格和知觉失常等心理测量以及大麻代谢物的尿液测量相关。总而言之，这些数据可能有助于阐明在大麻使用中观察到的已知认知功能障碍是否部分与早期感觉信息处理和/或神经同步的干扰有关。