Plaque Characterization with Vascular MR Micro-Coils

使用血管 MR 微线圈表征斑块

基本信息

批准号：
7108314
负责人：
DAVID Lynn WILSON
金额：
$ 20.8万
依托单位：
INTERVENTIONAL IMAGING, INC.
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-05-01 至 2008-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7108314
关键词：
atherosclerotic plaque bioimaging /biomedical imaging biomedical equipment cardiovascular disorder diagnosis cardiovascular imaging /visualization classification computer program /software computer system design /evaluation diagnostic catheterization histology magnetic resonance imaging method development pathology sectioning three dimensional imaging /topography training

项目摘要

DESCRIPTION (provided by applicant): Interventional Imaging Incorporated (I3) is developing clinical-grade catheters with intravascular MR micro- oils that can provide high resolution, high SNR images of the blood vessel wall at clinical field strengths. We believe that such images should enable one to characterize plaque tissue types (e.g., fibro-fatty plaque, advanced necrotic core, or unstable fibrous cap) and determine vulnerable lesions. I3 and researchers at Case Western Reserve University will develop experimental and computer methods to test this hypothesis using MR images of vessel segments from human cadavers. A special cryo-microtome/imaging device will be used to obtain "ground truth" pathology maps that can be accurately registered to the MR images. Computer classification techniques will be applied to multiple MR images having different contrasts and results will be statistically compared to pathology maps. It is believed that thorough evaluation requires a large number of vessel samples with a range of pathologies, and techniques for improved experimental throughput will be investigated. If Phase I goals are met, we will continue with large sample, well designed experiments to test both human and computer tissue classification of blood vessel disease using micro-coil imaging. If plaque tissue types can be reliably classified using micro-coil images, this should create extraordinary excitement in a marketplace clamoring for methods to diagnose vulnerable plaque. Relevance to Public Health, Interventional Imaging Incorporated (I3) and researchers at Case Western Reserve University will develop methods for improved detection and staging of blood vessel disease. Intravascular MR micro-coils will be used to obtain very high resolution, microscopic MR images of the vessel wall. Computer aided diagnosis techniques will be developed and applied to the image data that will determine the type of plaque in the lesion (e.g., fibro-fatty plaque, advanced necrotic core, or unstable fibrous cap) and determine its vulnerability for rupture, which can be a life threatening event.

描述（由申请人提供）：介入成像公司 (I3) 正在开发具有血管内 MR 微油的临床级导管，可以在临床现场强度下提供血管壁的高分辨率、高 SNR 图像。我们认为，此类图像应该能够表征斑块组织类型（例如，纤维脂肪斑块、晚期坏死核心或不稳定的纤维帽）并确定易损病变。 I3 和凯斯西储大学的研究人员将开发实验和计算机方法，使用人类尸体血管片段的 MR 图像来检验这一假设。将使用特殊的冷冻切片机/成像设备来获得可以准确配准到 MR 图像的“真实”病理图。计算机分类技术将应用于具有不同对比度的多个MR图像，并且结果将与病理图进行统计比较。据信，彻底的评估需要大量具有一系列病理学的血管样本，并且将研究提高实验通量的技术。如果第一阶段的目标得以实现，我们将继续进行大样本、精心设计的实验，以使用微线圈成像来测试血管疾病的人体和计算机组织分类。如果可以使用微线圈图像对斑块组织类型进行可靠分类，那么这应该会在迫切需要诊断易损斑块的方法的市场中引起极大的兴奋。与公共卫生相关，介入成像公司 (I3) 和凯斯西储大学的研究人员将开发改进血管疾病检测和分期的方法。血管内 MR 微线圈将用于获得血管壁的高分辨率显微 MR 图像。将开发计算机辅助诊断技术并将其应用于图像数据，以确定病变中斑块的类型（例如，纤维脂肪斑块、晚期坏死核心或不稳定纤维帽）并确定其破裂的脆弱性，这可以是危及生命的事件。