Plaque Characterization with Vascular MR Micro-Coils

使用血管 MR 微线圈表征斑块

基本信息

批准号：
7108314
负责人：
DAVID Lynn WILSON
金额：
$ 20.8万
依托单位：
INTERVENTIONAL IMAGING, INC.
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-05-01 至 2008-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7108314
关键词：
atherosclerotic plaque bioimaging /biomedical imaging biomedical equipment cardiovascular disorder diagnosis cardiovascular imaging /visualization classification computer program /software computer system design /evaluation diagnostic catheterization histology magnetic resonance imaging method development pathology sectioning three dimensional imaging /topography training

项目摘要

DESCRIPTION (provided by applicant): Interventional Imaging Incorporated (I3) is developing clinical-grade catheters with intravascular MR micro- oils that can provide high resolution, high SNR images of the blood vessel wall at clinical field strengths. We believe that such images should enable one to characterize plaque tissue types (e.g., fibro-fatty plaque, advanced necrotic core, or unstable fibrous cap) and determine vulnerable lesions. I3 and researchers at Case Western Reserve University will develop experimental and computer methods to test this hypothesis using MR images of vessel segments from human cadavers. A special cryo-microtome/imaging device will be used to obtain "ground truth" pathology maps that can be accurately registered to the MR images. Computer classification techniques will be applied to multiple MR images having different contrasts and results will be statistically compared to pathology maps. It is believed that thorough evaluation requires a large number of vessel samples with a range of pathologies, and techniques for improved experimental throughput will be investigated. If Phase I goals are met, we will continue with large sample, well designed experiments to test both human and computer tissue classification of blood vessel disease using micro-coil imaging. If plaque tissue types can be reliably classified using micro-coil images, this should create extraordinary excitement in a marketplace clamoring for methods to diagnose vulnerable plaque. Relevance to Public Health, Interventional Imaging Incorporated (I3) and researchers at Case Western Reserve University will develop methods for improved detection and staging of blood vessel disease. Intravascular MR micro-coils will be used to obtain very high resolution, microscopic MR images of the vessel wall. Computer aided diagnosis techniques will be developed and applied to the image data that will determine the type of plaque in the lesion (e.g., fibro-fatty plaque, advanced necrotic core, or unstable fibrous cap) and determine its vulnerability for rupture, which can be a life threatening event.

描述（由申请人提供）：介入的成像成像（i3）正在开发具有血管内MR微油的临床级导管，这些导管可以提供高分辨率，可提供高分辨率，在临床场强度下血管壁的高SNR图像。我们认为，这样的图像应该使人们能够表征斑块组织类型（例如，纤维粘合斑块，晚期坏死核或不稳定的纤维帽）并确定脆弱的病变。 I3和Case Western Reserve University的研究人员将开发实验和计算机方法，以使用人尸体的船只段的MR图像来检验该假设。一种特殊的冷冻微观/成像设备将用于获得可以准确注册到MR图像的“地面真相”病理图。计算机分类技术将应用于具有不同对比度的多个MR图像，结果将在统计上与病理图相比。据认为，彻底的评估需要大量具有一系列病理的血管样品，并将研究改进实验吞吐量的技术。如果达到了I期目标，我们将继续进行大型样品，设计精良的实验，以使用微型圈成像测试血管疾病的人体和计算机组织分类。如果可以使用微型机油图像可靠地对斑块组织类型进行可靠的分类，那么这应该在市场上引起非凡的兴奋，以示诊断易受攻击的斑块。与公共卫生，介入成像成立（I3）和凯斯西部储备大学的研究人员有关，将开发改进血管疾病的检测和分期的方法。血管内MR微型机油将用于获得血管壁的非常高的显微镜MR图像。将开发计算机辅助诊断技术并将其应用于图像数据，这些图像数据将确定病变中的斑块类型（例如，纤维粘合斑块，高级坏死核或不稳定的纤维帽）并确定其破裂的脆弱性，这可能是危及生命的事件。