Aerodynamic Study for Laryngeal Function Assessment Using Airflow Interruption Me

使用气流中断 Me 进行喉功能评估的空气动力学研究

• 批准号: 7323417
• 负责人: Jack J Jiang
• 金额: $ 30.92万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7323417
• 关键词: Accounting; Acoustics; Aftercare; Age; Attenuated; Automobile Driving; Biomechanics; Characteristics; Clinical; Clinical Trials; Computer Simulation; Computer-Aided Design; Computers; Condition; Data; Data Analyses; Development; Devices; Diagnosis; Dimensions; Evaluation; Feedback; Finite Element Analysis; Functional disorder; Gender; Goals; Human; Interruption; Invasive; Laryngeal Paralysis; Larynx; Lead; Lung; Masks; Measurable; Measurement; Measures; Methods; Modeling; Nature; Nodule; Normal Range; Otolaryngology; Output; Parkinson Disease; Pathologic; Pathology; Patients; Phonation; Physiology; Polyps; Procedures; Reflex action; Request for Applications; Research; Research Personnel; Resistance; Sensitivity and Specificity; Shapes; Speech; Speed; Support of Research; System; Techniques; Technology; Testing; Theoretical model; Treatment Effectiveness; Urination; Voice; Voice Disorders; base; cinematography; computerized; concept; design; human subject; improved; instrumentation; larynx Carcinoma; novel; practical application; pressure; prevent; programs; sound; success; theories; treatment effect; vibration; vocal cord; voice therapy

DESCRIPTION (provided by applicant): Human phonation is driven by airflow from the lung. The larynx serves as an energy converter, transferring aerodynamic energy into acoustical energy. Aerodynamic parameters provide a practical assessment for laryngeal function during phonation. Traditional aerodynamic measurement technologies have many limitations. Specifically, measuring airflow after the vocal tract does not represent the driving parameters such as subglottal pressure. Recent progress in research suggests new parameters such as phonation threshold pressure (PTP) and vocal efficiency are essential to represent laryngeal function because they take into account both aerodynamic and acoustic energy forms. A non-invasive aerodynamic measurement system based on flow interruption technology is needed to assess laryngeal function, pathologies, and evaluate the effects of treatment. This proposal focuses on applying current aerodynamic theories and computerized instrumentation to improve methods of assessing laryngeal function. Specifically, we hope this novel system can assess subglottal pressure (SGP), vocal efficiency (VE), AC/DC ratio of glottal flow, and phonation threshold pressure (PTP). New parameters, phonation threshold flow (PTF) and phonation threshold power (PTPw), will also be investigated. The study has two interrelated parts. In part I, research will focus on developing a better airflow interruption system with computer aided design. Using an acoustically adapted model and a Finite Element Analysis (FEA) model, we will quantitatively describe the aerodynamics of the measurement system, such as the sound projection and the pressure and flow fields during and after airflow interruption. Computer modeling will help design and optimize the effects of the dimensions and shape of the measurement system. Research will focus on issues in adapting the designed system to human subjects. The measurement accuracy and comfort of various masks and mouthpieces will be investigated. The effects of audio-laryngeal reflexes will be determined, and then reduced by masking the subjects' audio feedback. A partial airflow interruption system will be developed which will not cease phonation; therefore, the measurements will be taken during phonation, as opposed to complete interruption systems that take measurements just after phonation stops. In part II, the improved measurement system developed in part I will be used to measure the laryngeal function of patients with vocal nodules and polyps, vocal fold paralysis, laryngeal carcinoma, and Parkinson's disease. The sensitivity and specificity of distinguishing normal from pathologic voices using aerodynamic parameters will be assessed based on the received operating characteristic (ROC) analysis. Aerodynamic parameters will also be measured before and after treatment to evaluate treatment effectiveness.

描述（由申请人提供）：人类发声是由肺部的气流驱动的。喉是能量转换器，将空气动力的能量转移到声学能量中。空气动力学参数在发声过程中为喉功能提供了实际评估。传统的空气动力学测量技术有许多局限性。具体而言，测量声带后的气流不代表驱动参数，例如次数下压力。研究的最新进展表明，诸如发音阈值压力（PTP）和人声效率等新参数对于代表喉功能至关重要，因为它们考虑了空气动力和声学能的形式。需要基于流动中断技术的非侵入性空气动力学测量系统来评估喉功能，病理学并评估治疗的影响。该建议着重于应用当前的空气动力学理论和计算机仪器来改善评估喉功能的方法。具体而言，我们希望这个新型系统可以评估磁场下压力（SGP），人声效率（VE），glottal流量的AC/DC比和发声阈值压力（PTP）。还将研究新的参数，发声阈值流量（PTF）和发音阈值功率（PTPW）。该研究有两个相互关联的部分。在第一部分中，研究将集中于使用计算机辅助设计开发更好的气流中断系统。使用声学上的模型和有限元分析（FEA）模型，我们将定量描述测量系统的空气动力学，例如声音投影以及气流中断期间和之后的压力和流场。计算机建模将有助于设计和优化测量系统的尺寸和形状的影响。研究将重点放在将设计系统适应人类受试者的问题上。将研究各种口罩和喉舌的测量精度和舒适性。将确定音频毛骨动力反射的影响，然后通过掩盖受试者的音频反馈来降低。将开发出部分气流中断系统，不会停止发声；因此，将在发声期间进行测量，而不是完成发音停止后进行测量的完整中断系统。在第二部分中，改进的测量系统将在第一部分中开发，用于测量声带和息肉患者的喉功能，声带瘫痪，喉癌和帕金森氏病。将根据接收的操作特征（ROC）分析来评估使用空气动力学参数区分正常声音的灵敏度和特异性。在治疗前后，还将测量空气动力学参数以评估治疗效果。