Pediatric Sleep Research Program

儿科睡眠研究计划

• 批准号: 6955952
• 负责人: Raouf S. Amin
• 金额: $ 14.66万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6955952
• 关键词: baroreceptors; baroreflex; blood pressure; cardiovascular disorder; clinical research; echocardiography; heart rate; heart ventricle; human morbidity; human subject; longitudinal human study; middle childhood (6-11); patient oriented research; sensory neuropathy; sleep apnea; wakefulness

DESCRIPTION (provided by applicant): Immediate Goals: To examine the cardiovascular morbidity in children with obstructive sleep apnea (OSA). Career Development Goals: To provide sufficient time to develop a research training program in pediatric sleep medicine and build on the current patient-oriented research. Research Project: The project will test the hypothesis that children with OSA have baroreceptor dysfunction, which correlates with BP abnormalities, which in turn predict end organ injury in the form of an increase in left ventricular mass. The goal is to examine in children (1) the interaction between OSA and baroreflex dysfunction, (2) the relation of OSA severity and baroreflex dysfunction to abnormalities in blood pressure control during wakefulness and sleep, (3) the association of the diminished baroreflex gain and impaired blood pressure control with an index of end organ damage, the left ventricular mass index, and (4) whether effective treatment of OSA results in significant improvement in baroreceptor function, blood pressure control and a decrease in left ventricular mass index. We will accomplish these aims by studying 7-13 year-old children with OSA and a matched group of normal children in a cross-sectional design. Baroreceptor function, 24-hour ambulatory blood pressure and left ventricular mass index will be studied. Baroreceptor function will be measured by non-invasive techniques based on combined computer analysis of heart rate and blood pressure measured by portapres. 24-hour ambulatory blood pressure will be measured by a spacelab monitor, and left ventricular mass index will be measured by direct M-mode echocardiogram. In a longitudinal study, the effect of adequate treatment of OSA on baroreceptor function, daytime and nocturnal blood pressure and left ventricular mass index will be examined. A cohort of children with OSA and matched controls will be followed for a period of 12 months after treatment. (End of Abstract)

描述（由申请人提供）： 近期目标：检查患有阻塞性睡眠呼吸暂停 (OSA) 的儿童的心血管发病率。 职业发展目标：提供足够的时间来制定儿科睡眠医学研究培训计划，并以当前以患者为导向的研究为基础。 研究项目：该项目将检验患有 OSA 的儿童有压力感受器功能障碍的假设，压力感受器功能障碍与血压异常相关，而血压异常反过来又以左心室质量增加的形式预测终末器官损伤。 目标是在儿童中检查 (1) OSA 和压力反射功能障碍之间的相互作用， (2) OSA 严重程度和压力反射功能障碍与清醒和睡眠期间血压控制异常的关系，(3) 压力反射增益减少和血压控制受损与终末器官损伤指数（左心室质量指数）之间的关系，（4）OSA的有效治疗是否会导致压力感受器功能、血压控制和左心室质量指数下降的显着改善。 我们将通过横断面设计研究 7-13 岁患有 OSA 的儿童和一组匹配的正常儿童来实现这些目标。 将研究压力感受器功能、24 小时动态血压和左心室质量指数。 压力感受器功能将通过基于对 portapres 测量的心率和血压进行组合计算机分析的非侵入性技术来测量。 24小时动态血压将通过空间实验室监视器测量，左心室质量指数将通过直接M型超声心动图测量。 在一项纵向研究中，将检查适当的 OSA 治疗对压力感受器功能、白天和夜间血压以及左心室质量指数的影响。 一组患有 OSA 的儿童和匹配的对照组将在治疗后进行为期 12 个月的随访。 （摘要完）