PhD on Optical Coherence Tomography in Visible

可见光光学相干断层扫描博士

• 批准号: 2774384
• 金额: --
• 依托单位: University of Kent
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2774384
• 关键词: PhD; Optical; Coherence; Tomography; Visible

I am proposing to use the PhD position to research and develop solutions to overcome some of the challenges faced by Optical Coherence Tomography (OCT) instruments when driven by optical sources emitting in the visible (VIS) spectral range, for imaging the human eye (more specifically the retina), in-vivo. The main advantage of developing VIS-OCT instruments is due to their diagnostic potential allowed by their improved lateral and axial resolution when imaging the eye compared to the technology currently used with near-infrared light sources.One of the challenges to be faced with using a visible range light source is the attenuation of light when the OCT imaging technique is applied in vivo and in particular, the eye. The biological tissue light must travel across the eye to reach the retina, is characterised by a quite large optical attenuation coefficient, and therefore the number of photons reaching the retina is low, and subsequently the images obtained are much poorer than those obtained using near-infrared light sources. Image quality is also affected by low levels of back-scattering of visible light on tissue, and the fact that a lower limit of optical power from the light source entering the eye is imposed in comparison to a near-infrared source which contributes to a large noise level in the OCT images obtained.Another aspect of the imaging technique which would be addressed is the way the image quality is determined by the use of camera-based OCT systems. Swept source OCT gives a better range of axial imaging in comparison to camera-based due to their narrow instantaneous coherence length. However swept sources are not available for the visible range and therefore this is an area where improvements need to be made to help the potential for visible light OCT to be used in new diagnostic technology.Addressing these issues to improve visible light OCT for biomedical imaging would enable us to produce high resolution images of the human retina (of the static tissue) and OCT angiography images of the micro-vasculature of the back of the eye. Researching the imaging technique would also allow development of an imaging instrument which is easier to build than those which do not use a visible light source, as well as the imaging method to provide potential for new spectroscopic techniques as a result.

我建议利用博士学位来研究和开发解决方案，以克服光学相干断层扫描（OCT）仪器所面临的一些挑战，当时是由在可见光（VIS）光谱范围内发出的光源驱动的，用于对人眼（更具体地说是视网膜）的成像，In-Vivo。与当前使用近红外光源相比，开发Vis-OCT仪器的主要优点是由于其对眼睛成像时的诊断潜力所致。使用可见光范围光源所面临的挑战之一是，当八十八个光范围的衰减是在八十八个范围内的衰减时，八十八个左成像技术在vivo中应用了，尤其是眼睛，尤其是眼睛。生物组织光必须穿过眼睛才能到达视网膜，其特征是光学衰减系数很大，因此到达视网膜的光子数量很低，随后获得的图像比使用近红外光源获得的图像要差得多。图像质量还受组织上可见光的后散射低水平的影响，并且与近红外源相比，强加了来自光源进入眼睛的光源的下限，该源在获得的OCT图像中有助于获得的OCT噪声水平。与基于摄像机的狭窄瞬时相干长度相比，扫描源OCT可提供更好的轴向成像。但是，扫描源不适用于可见范围，因此，这是需要进行改进的领域，以帮助可见光的潜力在新的诊断技术中使用。研究成像技术还将允许开发成像仪器，该成像仪器比不使用可​​见光源的成像仪器更容易构建，以及成像方法为新的光谱技术提供潜力。