Acceptance of Breast Cancer Chemoprevention Therapy

接受乳腺癌化学预防治疗

基本信息

批准号：
7114858
负责人：
MFON SAMUEL CYRUS-DAVID
金额：
$ 15.93万
依托单位：
BAYLOR COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-09-01 至 2008-08-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): My career goal is to become a skilled preventive oncologist who can independently conduct research projects to determine risk factors, risk-reduction modalities, and interventions to increase acceptance and use of breast, prostate, and cervical cancer prevention services in high-risk populations. Using the Transition Career Development Award (K22) grant, my immediate objectives are to identify the factors that influence the acceptance of breast cancer chemoprevention with selective estrogen receptor modulators (SERMs), and to increase the depth of my knowledge in this field by taking related didactic courses in behavioral science, health education and health promotion. I plan to attend national and international conferences, seminars, and symposia; serve in working and study groups in related fields; write scientific papers; and make presentations. The proposed research is important because breast cancer is the most common cancer among women. There will be an estimated 211,300 new cases and 39,800 deaths from breast cancer in the United States in 2003. SERMs such as tamoxifen are approved for chemoprevention therapy in women at high risk for breast cancer. Although tamoxifen was reported to reduce the risk of invasive breast cancer in high-risk women by 49%, breast cancer chemoprevention therapy has not gained wide acceptance. The few studies that have addressed the determinants of acceptance of chemoprevention therapy have used mainly clinical trial participants and included few minority women and women of low socioeconomic status. Consequently, there is little information on the correlates of chemoprevention therapy acceptance to provide a basis for educational interventions. The hypothesis of the proposed study is that women with an elevated risk for breast cancer will differ in their willingness to accept chemoprevention therapy with SERMs by socioeconomic status, ethnic/racial background, and level of knowledge and attitude about breast cancer chemoprevention. The specific aims of this proposal are (1) to validate a questionnaire to assess the attitude of women to accept breast cancer chemoprevention, (2) to quantitatively assess their knowledge and beliefs about breast cancer chemoprevention using the constructs of the Health Belief Model, and (3) to identify correlates of willingness to accept chemoprevention therapy. These aims will be achieved by using a cross-sectional survey of a random sample of 350 women stratified by menopausal status and race/ethnicity who are at increased risk for breast cancer and are ethnically representative of the Harris County, Texas population. Eligible participants will be recruited from women who visit the diagnostic/screening centers of The Rose organization in Houston. Women who consent to participate in the study will be assessed through telephone interviews using questionnaires. This project has the potential to provide further insight into the correlates of acceptance of chemoprevention therapy, especially in ethnic minority women, and so be a foundation for future educational intervention to improve the acceptance of breast cancer chemoprevention therapy.

描述（由申请人提供）：我的职业目标是成为一名熟练的预防肿瘤科医生，他们可以独立开展研究项目，以确定风险因素，减少风险方式和干预措施，以增加乳腺癌，前列腺癌和宫颈癌预防服务的接受和使用在高风险人群中。使用过渡职业发展奖（K22）赠款，我的直接目标是确定因选择性雌激素受体调节剂（SERM）（SERMS）（SERMS）（SERMS）的乳腺癌化学预防的因素，并通过采用相关的相关知识来提高我在该领域的深度行为科学，健康教育和健康促进的教学课程。我计划参加国家和国际会议，研讨会和研讨会；在相关领域的工作和学习组中任职；写科学论文；并进行演示。拟议的研究很重要，因为乳腺癌是女性中最常见的癌症。 2003年，美国估计有211,300例新病例和39,800例乳腺癌死亡。他莫昔芬等Serms批准在患有乳腺癌的高风险的女性中接受化学预防治疗。尽管据报道他莫昔芬可将高危女性侵入性乳腺癌的风险降低49％，但乳腺癌化学预防疗法并未得到广泛的接受。少数针对接受化学预防疗法的决定因素的研究主要使用了临床试验参与者，并且很少有社会经济地位低的少数妇女和妇女。因此，关于化学预防疗法接受的相关性的信息很少，可以为教育干预提供基础。拟议的研究的假设是，患有乳腺癌风险较高的妇女的接受意愿会有所不同通过社会经济地位，种族/种族背景以及有关乳腺癌化学预防的知识水平和态度的化学预防疗法。该提案的具体目的是（1）验证问卷，以评估妇女接受乳腺癌化学预防的态度，（2）使用健康信念模型的构建体和（3）确定接受化学预防疗法意愿的相关性。这些目标将通过对350名因绝经状态和种族/种族分层的妇女的随机样本进行横断面调查来实现，这些妇女患乳腺癌的风险增加，并且在种族上代表了德克萨斯州哈里斯县的种族。符合条件的参与者将从访问休斯顿玫瑰组织的诊断/筛查中心的妇女中招募。同意参加研究的妇女将通过调查表进行电话访谈评估。该项目有可能进一步了解化学预防疗法接受的相关性，尤其是在少数民族妇女中，因此成为未来教育干预的基础，以改善接受乳腺癌化学预防疗法的接受。