EMOTION OF PAIN: A NEUROBIOLOGICAL ANALYSIS

疼痛情绪:神经生物学分析

基本信息

  • 批准号:
    7037643
  • 负责人:
  • 金额:
    $ 30.44万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2003
  • 资助国家:
    美国
  • 起止时间:
    2003-03-01 至 2010-03-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): All animals, including humans, react with distinct emotional coping strategies when confronted with stressors. The immediate reactions to stressors are innate behavior patterns with a phylogenetic history of enabling individuals to cope with threats. The prototypical threat to an individual is exposure to a painful stimulus, and recent findings indicate that painful stimuli engage neural circuits that control the execution of defensive behaviors. Within this context, the emotional dimension of pain belongs to a class of sensory experience that represents threat to the individual and governs the production of defensive reactions that enable the individual cope with the threat. Because the neural circuits that control the execution of defensive behaviors are known to a considerable degree, these circuits can be used to evaluate the mechanisms that underlie the innate emotional reaction to painful stimuli. An understanding of how these neural circuits are engaged by a painful stimulus also provides a foundation to study how the immediate emotional reactions to pain produce enduring effects on the individual. Alterations in the circuitry that controls defensive responding are implicated in conditions such as fear, anxiety, depression, frustration, and anger. These secondary emotional reactions are components of the human pain experience, and contribute to the suffering and disability associated with pain. Rats produce a particular type of vocalization (vocalization after discharge, VAD) when exposed to a painful stimulus or confronted with a predator. These vocalizations reflect the rat's immediate emotional reaction to threatening stimuli. These vocalizations are used as a model behavioral system to investigate how painful stimuli engage mesolimbic circuits that control execution of defensive reactions to threats. Two interconnected core structures (ventromedial hypothalamus and periaqueductal gray) control execution of defensive behaviors, and the proposal initiates a systematic evaluation of how painful stimulation activates this neural circuit. The amygdala is the best-characterized modulator of these core structures, and the proposal also evaluates how amygdaloid subnuclei (medial, basolateral, central) enhance or suppress pain transmission through these sites.
描述(由申请人提供):所有动物(包括人类)在面对压力源时会以明显的情感应对策略做出反应。对压力源的直接反应是天生的行为模式,具有使个人能够应对威胁的系统发育史。对个人的原型威胁是暴露于痛苦的刺激中,最近的发现表明,痛苦的刺激与控制防御行为执行的神经回路相关。在这种情况下,痛苦的情绪维度属于一类感官体验,这些感觉体验代表了对个人的威胁,并控制了防御​​反应的产生,从而使个人应对威胁。由于控制防御行为的执行的神经回路是相当多的,因此可以使用这些电路来评估对痛苦刺激的先天情绪反应的基础的机制。了解这些神经回路如何通过痛苦的刺激参与其中,也为研究疼痛的直接情绪反应如何产生对个体的持久影响。控制防御响应的电路的改变与恐惧,焦虑,抑郁,沮丧和愤怒等条件有关。这些次要情绪反应是人类疼痛经历的组成部分,并导致与疼痛相关的痛苦和残疾。当暴露于痛苦的刺激或与捕食者面对面时,大鼠会产生一种特定类型的发声(排出后的发声,VAD)。这些发声反映了大鼠对威胁刺激的直接情感反应。这些发声被用作模型行为系统,以调查痛苦的刺激如何吸引中脑旁的电路,以控制对威胁的防御反应的执行。两种相互连接的核心结构(腹侧下丘脑和周围灰色)控制防御行为的执行,该提案启动了对疼痛刺激如何激活该神经回路的系统评估。杏仁核是这些核心结构的最佳特征调节剂,该提案还评估了杏仁核下核(内侧,基底外侧,中心)如何增强或抑制通过这些部位的疼痛传播。

项目成果

期刊论文数量(11)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Pain and emotion: a biopsychosocial review of recent research.
  • DOI:
    10.1002/jclp.20816
  • 发表时间:
    2011-09
  • 期刊:
  • 影响因子:
    3
  • 作者:
    Lumley, Mark A.;Cohen, Jay L.;Borszcz, George S.;Cano, Annmarie;Radcliffe, Alison M.;Porter, Laura S.;Schubiner, Howard;Keefe, Francis J.
  • 通讯作者:
    Keefe, Francis J.
NMDA or non-NMDA receptor antagonism within the amygdaloid central nucleus suppresses the affective dimension of pain in rats: evidence for hemispheric synergy.
  • DOI:
    10.1016/j.jpain.2011.12.007
  • 发表时间:
    2012-04
  • 期刊:
  • 影响因子:
    4
  • 作者:
    Spuz, Catherine A.;Borszcz, George S.
  • 通讯作者:
    Borszcz, George S.
N-methyl-D-aspartate receptor agonism and antagonism within the amygdaloid central nucleus suppresses pain affect: differential contribution of the ventrolateral periaqueductal gray.
杏仁核中央核内的 N-甲基-D-天冬氨酸受体激动和拮抗作用抑制疼痛影响:腹外侧导水管周围灰质的差异贡献。
Contribution of the periaqueductal gray to the suppression of pain affect produced by administration of morphine into the intralaminar thalamus of rat.
  • DOI:
    10.1016/j.jpain.2008.10.011
  • 发表时间:
    2009-04
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Munn EM;Harte SE;Lagman A;Borszcz GS
  • 通讯作者:
    Borszcz GS
Separating analgesia from reward within the ventral tegmental area.
  • DOI:
    10.1016/j.neuroscience.2014.01.009
  • 发表时间:
    2014-03-28
  • 期刊:
  • 影响因子:
    3.3
  • 作者:
    Schifirneţ E;Bowen SE;Borszcz GS
  • 通讯作者:
    Borszcz GS
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GEORGE S. BORSZCZ其他文献

GEORGE S. BORSZCZ的其他文献

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{{ truncateString('GEORGE S. BORSZCZ', 18)}}的其他基金

EMOTION OF PAIN: A NEUROBIOLOGICAL ANALYSIS
疼痛情绪:神经生物学分析
  • 批准号:
    6599203
  • 财政年份:
    2003
  • 资助金额:
    $ 30.44万
  • 项目类别:
EMOTION OF PAIN: A NEUROBIOLOGICAL ANALYSIS
疼痛情绪:神经生物学分析
  • 批准号:
    6875803
  • 财政年份:
    2003
  • 资助金额:
    $ 30.44万
  • 项目类别:
EMOTION OF PAIN: A NEUROBIOLOGICAL ANALYSIS
疼痛情绪:神经生物学分析
  • 批准号:
    6702277
  • 财政年份:
    2003
  • 资助金额:
    $ 30.44万
  • 项目类别:
EMOTION OF PAIN AND ITS SUPPRESSION
痛苦的情绪及其抑制
  • 批准号:
    2379654
  • 财政年份:
    1989
  • 资助金额:
    $ 30.44万
  • 项目类别:
COMPARISON OF SPINAL AND SUPRASPINAL PAIN THRESHOLDS
脊柱和脊柱上疼痛阈值的比较
  • 批准号:
    3477821
  • 财政年份:
    1989
  • 资助金额:
    $ 30.44万
  • 项目类别:
COMPARISON OF SPINAL AND SUPRASPINAL PAIN THRESHOLDS
脊柱和脊柱上疼痛阈值的比较
  • 批准号:
    3477818
  • 财政年份:
    1989
  • 资助金额:
    $ 30.44万
  • 项目类别:
EMOTION OF PAIN AND ITS SUPPRESSION
痛苦的情绪及其抑制
  • 批准号:
    2635704
  • 财政年份:
    1989
  • 资助金额:
    $ 30.44万
  • 项目类别:
COMPARISON OF SPINAL AND SUPRASPINAL PAIN THRESHOLDS
脊柱和脊柱上疼痛阈值的比较
  • 批准号:
    3477820
  • 财政年份:
    1989
  • 资助金额:
    $ 30.44万
  • 项目类别:
COMPARISON OF SPINAL AND SUPRASPINAL PAIN THRESHOLDS
脊柱和脊柱上疼痛阈值的比较
  • 批准号:
    3477819
  • 财政年份:
    1989
  • 资助金额:
    $ 30.44万
  • 项目类别:
EMOTION OF PAIN AND ITS SUPPRESSION
痛苦的情绪及其抑制
  • 批准号:
    6139485
  • 财政年份:
    1989
  • 资助金额:
    $ 30.44万
  • 项目类别:

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