Cortical Regulation of a Whisking CPG

搅拌 CPG 的皮质调节

• 批准号: 7112802
• 负责人: Nathan P Cramer
• 金额: $ 3.09万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-14 至 2009-03-13
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7112802
• 关键词: action potentials; brain regulatory center; electromyography; laboratory rat; motor cortex; motor neurons; neuroanatomy; neuromuscular function; neuroregulation; neurotransmitter antagonist; predoctoral investigator; psychomotor function; serotonin; vibrissae

DESCRIPTION (provided by applicant): Evidence suggests rhythmic whisker movements in rats are driven by a subcortical central pattern generator (CPG) under control of the whisker motor cortex (wMCx). Additionally, it has been demonstrated that serotonin (5HT) is necessary for whisking. My goal is to investigate a subset of 5HT neurons in the brainstem of adult rats that are likely to comprise an integral part of the whisking CPG. I will investigate the control exerted by the wMCx over this putative CPG component and the impact that the resulting CPG modulation has on whisking frequencies. I propose that the 5HT CPG determines firing frequency of whisker motor units by regulating the delivery of 5HT to motoneurons in the lateral facial nucleus. I further propose that 5HT regulates motor unit firing rates by facilitating a persistent inward current in whisker motoneurons (wMNs) in a dose dependent manner. I will investigate the ability of 5HT to facilitate a dose dependent PIC in whisker motoneurons and its relation to whisker motoneuron firing frequency.

描述（由申请人提供）：有证据表明，大鼠的有节奏的胡须运动是由皮层下中央模式发生器（CPG）在胡须运动皮层（wMCx）的控制下驱动的。此外，已证明血清素 (5HT) 对于搅拌是必需的。我的目标是研究成年大鼠脑干中的 5HT 神经元子集，这些神经元可能构成搅拌 CPG 的组成部分。我将研究 wMCx 对这个假定的 CPG 组件所施加的控制以及由此产生的 CPG 调制对搅拌频率的影响。我建议 5HT CPG 通过调节 5HT 向侧面面核运动神经元的传递来确定胡须运动单位的放电频率。我进一步提出，5HT 通过以剂量依赖性方式促进晶须运动神经元 (wMN) 中持续的内向电流来调节运动单位放电率。我将研究 5HT 促进晶须运动神经元剂量依赖性 PIC 的能力及其与晶须运动神经元放电频率的关系。