Role of Genotype and Maternal Smoking on Brain MAO A

基因型和母亲吸烟对大脑 MAO A 的作用

• 批准号: 7092109
• 负责人: JOANNA S FOWLER
• 金额: $ 13.71万
• 依托单位: BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-05 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7092109
• 关键词: MAO inhibitors; Macaca; amine oxidase (flavin); behavioral /social science research tag; behavioral genetics; bioimaging /biomedical imaging; clinical research; compulsive behavior; developmental genetics; early experience; embryo /fetus toxicology; genotype; human subject; isozymes; molecular /cellular imaging; neurochemistry; neurogenetics; neuropharmacology; neurophysiology; neuropsychological tests; neuropsychology; personality; pharmacogenetics; positron emission tomography; tobacco; tobacco abuse; MAO inhibitors; Macaca; amine oxidase (flavin); behavioral /social science research tag; behavioral genetics; bioimaging /biomedical imaging; clinical research; compulsive behavior; developmental genetics; early experience; embryo /fetus toxicology; genotype; human subject; isozymes; molecular /cellular imaging; neurochemistry; neurogenetics; neuropharmacology; neurophysiology; neuropsychological tests; neuropsychology; personality; pharmacogenetics; positron emission tomography; tobacco; tobacco abuse

DESCRIPTION (provided by applicant): This is a new application for K05 Senior Scientist Award. The applicant, Dr. Joanna S. Fowler, Director of the Center for Translational Neuroimaging is an organic chemist with a distinguished record of accomplishments in the development and applications of radiotracers for the neurosciences including the development of 18FDG, the development of the first radiotracers for monoamine oxidase (MAO) (and the discovery that smokers have reduced brain MAO) and the application of PET in the study of drug addiction. She is also a sought after lecturer in bringing the power of science and brain imaging to the problem of drug addiction. She is currently mentoring several junior scientists in addition to her administrative duties as Center Director. If funded, this K award will provide 60% salary support, which will provide at least 75% protected time to focus intensely on her new interests in understanding the links between genes, the environment and behavior, and on mentoring. In support of this application, the Department has agreed to use the funds released from the Program to hire an administrator to assume the administrative duties that are now performed by Dr. Fowler. There are 2 major activities: (1) Research (60%): to investigate the role of monoamine oxidase (MAO) genotype and maternal smoking on brain MAO, brain function and behavior and (2) Mentoring (15%): to mentor junior clinical scientists, graduate students and post-doctoral fellows in trans-disciplinary research related to substance abuse. The research in this application takes advantage of outstanding collaborators at Brookhaven, SUNY Stony Brook and SUNY Downstate and Kings College (London, UK) and is funded by our major Department of Energy grant which was recently peer reviewed and renewed for 5 years. These goals build on the urgent need to understand the role of gene-brain-behavior relationships and developmental stressors in substance abuse and the need to train and inspire scientists across disciplines to respond to the major public health problems created by drug addiction.

描述（由申请人提供）： 这是K05高级科学家奖的新申请。申请人，翻译神经影像中心主任Joanna S. Fowler博士是一名有机化学家，在神经科学的开发和应用中具有杰出的成就记录，包括18FDG的开发，包括18FDG的开发，开发了单胺氧化酶（Mao氧化酶（Mao）的第一个放射性脱位剂（MAO）的启动（MAO）（以及对MAO的应用程序）和烟雾的启用。她还是一位受过2的讲师，将科学和大脑成像的力量带入吸毒问题。她目前还指导几位初级科学家，除了担任中心主任的行政职责外。如果获得资助，该K奖将提供60％的薪水支持，这将为至少75％的保护时间提供重点，以重点关注她的新利益，以理解基因，环境和行为以及指导之间的联系。为了支持此申请，该部门已同意使用该计划中发布的资金聘请管理员来承担福勒博士现在执行的行政职责。有2种主要活动：（1）研究（60％）：研究单胺氧化酶（MAO）基因型和孕妇吸烟对脑MAO，脑功能和行为的作用以及（2）指导（15％）：对与药物滥用有关的跨学科研究中的指导初级临床科学家，研究生和博物研究后的研究员。该应用程序的研究利用了布鲁克黑文，纽约州纽约州纽约州立大学和国王学院（英国伦敦）的杰出合作者，并由我们的主要能源部资助资助，该授权最近经过同行评审并续签了5年。这些目标基于迫切需要了解基因 - 大脑行为关系和发育压力源在药物滥用中的作用，以及需要培训和激发科学家跨学科的科学家，以应对吸毒造成的主要公共卫生问题。