SWAN Sleep Study II - Michigan Center

SWAN 睡眠研究 II - 密歇根中心

• 批准号: 7099022
• 负责人: MARYFRAN R SOWERS
• 金额: $ 41.53万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7099022
• 关键词: African American; actigraphy; attitude; caucasian American; clinical research; cooperative study; epidemiology; fatigue; female; follicle stimulating hormone; health behavior; hormone regulation /control mechanism; human middle age (35-64); human subject; longitudinal human study; menopause; personal log /diary; polysomnography; psychic activity level; questionnaires; racial /ethnic difference; sleep; sleep disorders; socioeconomics; stress; vasomotion; women' s health

DESCRIPTION (provided by applicant): Sleep disruptions increase during mid-life in women, due in part to the effects of age itself, but also possibly due in part to the menopausal transition, i.e. changes in hormones, symptoms, and bleeding that occur during the menopausal transition. The current, revised proposal (Sleep II) will extend longitudinally the currently funded, multi-site, multi-ethnic cross-sectional study of sleep in midlife women (Sleep I). In Sleep I, field-based examinations were conducted with 370 midlife pre-, peri- and postmenopausal Caucasian, African-American, and Chinese women from four of seven study sites from the Study of Women's Health Across the Nation (SWAN, a longitudinal study of menopause and aging), using in-home polysomnography, daily diaries and actigraphs, and self-report sleep questionnaires. In Sleep II, using a Coordinated R01 mechanism, a second field-based examination will be conducted on the same sample of women (who will be aged 51-62 years), incorporating the same procedures. A widely-cited heuristic model of the pathophysiology of sleep disturbances will be applied to these longitudinal data to evaluate the development of menopause-related sleep disturbances in this multi-ethnic sample of women. This model attributes acute sleep disturbances to the combined effects of predisposing and precipitating factors, and persistence of chronic sleep disturbances beyond the acute stressor to perpetuating factors. The specific aims for this longitudinal assessment of sleep through the menopausal transition are to identify potential: 1) predisposing factors (race, low socioeconomic status, low levels of physical activity, high body mass index, smoking, history of sleep problems, poor health status); 2) precipitating factors (vasomotor symptoms, new adverse life events, rapid increases in follicle stimulating hormone) for acute sleep disturbances during the transition; 3) perpetuating factors (poor sleep hygiene, dysfunctional attitudes and beliefs about sleep, heightened cognitive and physiologic arousal at night, race) for chronic sleep disturbances during the transition; and 4) adverse effects of sleep disturbances on subsequent health status during the early postmenopause (worsening metabolic profile and quality of life, increased hypertension, physical limitations). The public health relevance of this research is to understand better the changes in the sleep of women from different racial and socioeconomic backgrounds and identify risk factors for sleep problems. The results can inform primary prevention of adverse health outcomes due to the menopause-related sleep disturbances.

描述（由申请人提供）：女性中期的睡眠中断，部分原因是年龄本身的影响，但也可能部分归因于绝经期的绝经，即激素，症状和过渡过程中发生的疾病的变化。当前的修订建议（Sleep II）将纵向扩展当前资助的中年女性睡眠的多站点，多种族的横断面研究（睡眠I）。在睡眠I中，通过370个中年，杂期和绝经后高加索人，非裔美国人和来自全国妇女健康研究中的七个研究地点中的四个研究地点（SWAN，纵向对更年期和aging的纵向研究）进行了基于现场的检查，并使用In-Home Polymnography，日常疾病和自助官员，来自全国妇女健康的研究站点（天鹅，纵向研究）。在Sleep II中，使用协调的R01机制，将对同一女性样本（将年龄在51-62岁）上进行第二个基于现场的检查，并结合了相同的程序。这些纵向数据将应用于睡眠障碍的病理生理学的广泛引用的启发式模型，以评估这种多民族女性样本中与更年期相关的睡眠障碍的发展。该模型将急性睡眠障碍归因于诱发和沉淀因子的综合作用，以及急性应激源以外的慢性睡眠障碍的持久性与永久性因素。 通过更年期过渡对睡眠进行纵向评估的具体目的是确定潜力：1）诱发因素（种族，社会经济状况低，体育锻炼水平低，体重高，体重指数，吸烟，睡眠问题史，健康状况不佳）； 2）在过渡过程中急性睡眠障碍，沉淀因子（血管舒张症状，新的不良生命事件，刺激激素的迅速增加）； 3）长期因素（睡眠卫生不良，对睡眠功能失调的态度和信念，晚上的认知和生理唤醒，种族繁荣）在过渡期间长期睡眠障碍； 4）睡眠障碍对绝经后早期健康状况的不利影响（代谢形象恶化和生活质量，高血压增加，身体局限性）。 这项研究的公共卫生相关性是更好地了解来自不同种族和社会经济背景的女性睡眠的变化，并确定睡眠问题的危险因素。由于更年期相关的睡眠障碍，结果可以为预防不良健康结果的主要预防。