Psychopathology, Cognition, and Suicide in Adolescents

青少年的精神病理学、认知和自杀

• 批准号: 6999784
• 负责人: CHRISTIANNE L. ESPOSITO-SMYTHERS
• 金额: $ 14.58万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6999784
• 关键词: adolescence (12-20); anxiety disorders; behavior test; behavioral /social science research tag; clinical research; cognition disorders; comorbidity; gender difference; interview; major depression; medical records; oppositional defiant disorder; patient oriented research; psychopathology; questionnaires; statistics /biometry; suicide

DESCRIPTION (provided by investigator): Major depressive disorder, disruptive behavior disorders, and anxiety disorders are all significantly associated with suicidal ideation and attempts in adolescents. Yet, the nature of the relation between psychopathology and suicidality has been greatly understudied. The purpose of this 3-year application is to test a cognitive mediational model to explain this relationship. Specifically, it is hypothesized that psychopathology is related to suicidality through unique dysfunctional cognitive processes and products linked with various clinical disorders in adolescents. The proposed study will also explore the manner in which comorbid forms of psychopathology affect dysfunctional cognitive processes and products, and suicidality in adolescents. It is hypothesized that depressed adolescents with comorbid psychopathology will exhibit more severe dysfunctional cognitive processes and products, and thus further increase their suicide risk. Secondarily, gender differences across mediational and comorbidity related findings would be explored. More complex competing models will also be tested. The proposed study will employ a cross-sectional design to test hypotheses. Two hundred and fifty psychiatrically hospitalized adolescents will be asked to complete a diagnostic interview and symptom inventories to assess psychopathology, as well as performance based measures and questionnaires to assess dysfunctional cognitive processes, cognitive products, and suicidality. Analyses will include the use of structural equation modeling (SEM) techniques, hierarchical regression analyses, and analyses of variance (ANOVA). Information obtained from this study will help explicate cognitive patterns in suicidal adolescents with varying forms of psychopathology and could ultimately be used to tailor cognitive-behavioral and multimode interventions for these high risk youth.

描述（由研究者提供）：重度抑郁症、破坏性行为障碍和焦虑症都与青少年的自杀意念和企图显着相关。然而，精神病理学与自杀之间关系的本质却未被充分研究。这个为期 3 年的应用程序的目的是测试认知中介模型来解释这种关系。具体来说，假设精神病理学通过独特的功能失调认知过程和与青少年各种临床疾病相关的产物与自杀有关。拟议的研究还将探讨精神病理学的共病形式如何影响功能失调的认知过程和产物以及青少年的自杀倾向。据推测，患有共病精神病理学的抑郁青少年将表现出更严重的功能失调的认知过程和产物，从而进一步增加他们的自杀风险。其次，将探讨中介和合并症相关发现的性别差异。还将测试更复杂的竞争模型。拟议的研究将采用横断面设计来检验假设。 250 名因精神病住院的青少年将被要求完成诊断访谈和症状清单，以评估精神病理学，以及基于表现的测量和问卷，以评估功能失调的认知过程、认知产物和自杀倾向。分析将包括使用结构方程建模 (SEM) 技术、层次回归分析和方差分析 (ANOVA)。从这项研究中获得的信息将有助于阐明具有不同形式的精神病理学的自杀青少年的认知模式，并最终可用于为这些高危青少年量身定制认知行为和多模式干预措施。

项目成果

Associations of the dopamine D4 receptor gene VNTR polymorphism with drug use in adolescent psychiatric inpatients.

多巴胺 D4 受体基因 VNTR 多态性与青少年精神病住院患者药物使用的关联。

• DOI: 10.1016/j.pbb.2006.11.001
• 发表时间: 2007
• 期刊: Pharmacology, biochemistry, and behavior
• 作者: McGeary,JohnE;Esposito-Smythers,Christianne;Spirito,Anthony;Monti,PeterM
• 通讯作者: Monti,PeterM

Social-Cognitive Moderators of the Relationship between Peer Victimization and Suicidal Ideation among Psychiatrically Hospitalized Adolescents.

• DOI: 10.1080/10926771.2014.883458
• 发表时间: 2014-03-01
• 期刊: Journal of aggression, maltreatment & trauma
• 作者: Wolff J;Esposito-Smythers C;Becker S;Seaboyer L;Rizzo C;Lichtenstein D;Spirito A
• 通讯作者: Spirito A

Posttraumatic stress disorder symptom clusters, suicidal ideation, and social support in a clinical adolescent sample.

• DOI: 10.1080/07481187.2020.1852629
• 发表时间: 2022
• 期刊: Death studies
• 影响因子: 3.8
• 作者: López R Jr;Defayette AB;Whitmyre ED;Williams CA;Esposito-Smythers C
• 通讯作者: Esposito-Smythers C

Dating violence victimization, dispositional aggression, and nonsuicidal self-injury among psychiatrically hospitalized male and female adolescents.

精神病院住院男性和女性青少年中的约会暴力受害、性格攻击和非自杀性自残。

• DOI: 10.1111/sltb.12081
• 发表时间: 2014
• 期刊: Suicide & life-threatening behavior
• 影响因子: 3.2
• 作者: Rizzo,ChristieJ;Esposito-Smythers,Christianne;Swenson,Lance;Hower,HeatherM;Wolff,Jennifer;Spirito,Anthony
• 通讯作者: Spirito,Anthony

Psychiatric and Cognitive Functioning in Adolescent Inpatients with Histories of Dating Violence Victimization.

有约会暴力受害史的青少年住院患者的精神和认知功能。

• DOI: 10.1080/10926771.2010.495034
• 发表时间: 2010
• 期刊: Journal of aggression, maltreatment & trauma
• 作者: Rizzo,ChristieJ;Esposito-Smythers,Christianne;Spirito,Anthony;Thompson,Ariel
• 通讯作者: Thompson,Ariel