Motherhood and Structural Plasticity in the Hippocampus

母性和海马体的结构可塑性

• 批准号: 7112541
• 负责人: BENEDETTA J LEUNER
• 金额: $ 4.6万
• 依托单位: PRINCETON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7112541
• 关键词: behavioral /social science research tag; bromodeoxyuridine; dendrites; dentate gyrus; estrogens; female; glucocorticoids; hippocampus; immunocytochemistry; laboratory rat; maternal behavior; neural plasticity; neuroanatomy; neuroendocrine system; neurogenesis; neuropsychology; newborn animals; oxytocin; postdoctoral investigator; postpartum; synapses

DESCRIPTION (provided by applicant): The postpartum period is accompanied by dramatic changes in hormones and behavior that are critical for reproductive success. In addition to changes in caregiving, pregnancy and the postpartum period are associated with alterations in non-reproductive behaviors, including certain types of learning and memory. Despite these reports, very little, if anything, is known about the neural consequences of motherhood, particularly for brain regions associated with cognitive function. The hippocampus is one such brain region that is also well-recognized for its capacity for structural plasticity. Specifically, various hormonal and experiential factors affect dendritic structure, the number of synapses and the production of new neurons in the hippocampus throughout adulthood. However, no studies to date have investigated the possibility that alterations in structural plasticity occur in the hippocampus during the postpartum period. Thus, the proposed studies will explore the following specific aims: 1) To determine whether structural plasticity in the hippocampus is altered during the postpartum period 2) To evaluate whether hormonal and experiential changes associated with the postpartum period underlie changes in structural plasticity in the hippocampus.

描述（由申请人提供）：产后时期伴随着激素和行为的巨大变化，这对于生殖成功至关重要。除了护理，怀孕和产后时期的变化还与非复制行为的改变有关，包括某些类型的学习和记忆。尽管有这些报道，但对母性的神经后果的了解很少，特别是对于与认知功能相关的大脑区域。海马是这样的大脑区域，其结构可塑性的能力也被广泛认可。具体而言，各种荷尔蒙和体验因素都会影响树突结构，突触的数量以及整个成年期海马中新神经元的产生。但是，迄今为止，尚无研究调查在产后海马发生结构可塑性改变的可能性。因此，拟议的研究将探讨以下特定目的：1）确定在产后期间海马中的结构可塑性是否改变了2），以评估与产后时期相关的激素和体验变化是否与海马结构可变性有关。