Longitudinal fMRI Study of Youth at Risk for Drug Abuse

有药物滥用风险的青少年的纵向功能磁共振成像研究

• 批准号: 7097989
• 负责人: Mary M Heitzeg
• 金额: $ 14.53万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7097989
• 关键词: adolescence (12-20); amygdala; behavioral /social science research tag; behavioral genetics; brain imaging /visualization /scanning; clinical research; corpus striatum; disease /disorder proneness /risk; drug abuse; functional magnetic resonance imaging; genetic polymorphism; high risk behavior /lifestyle; human subject; longitudinal human study; pediatrics; prefrontal lobe /cortex; psychopathology; substance abuse epidemiology; substance abuse related behavior

DESCRIPTION (provided by applicant): This Mentored Research Scientist Development Award will support the candidate in establishing an independent research career using longitudinal developmental neuroimaging to investigate genetic risk for substance use disorders (SUDs). Career development training areas include: 1) Functional magnetic resonance imaging (fMRI) methods and statistical analyses with a particular focus on pediatric neuroimaging; 2) The genetic basis of complex behaviors, and gene-brain-behavior relationships; 3) Theoretical constructs regarding risk of psychopathology; and 4) Longitudinal research methods and statistical analyses. The proposed research plan is to examine the contribution of specific genetic polymorphisms and early-life stress on the neural correlates of SUD risk in children using fMRI. Both behavioral and emotional dysregulation at an early age are strong predictors of SUDs later in life. A complex neuronal circuit, including the striatum, amygdala and prefrontal cortex, regulates these processes. The proposed research plan will investigate these neural systems cross-sectionally in a sample of 7 to 11 year old boys and girls (n=60) from the ongoing UM/MSU Longitudinal Study (R37 AA07065), and longitudinally in this sample at 2-year intervals. The cross-sectional study will investigate effects of, and interactions between, early stress and genetic variants (COMT, SLC6A4, MAO-A, TPH, BDNF) on brain responses to tasks designed to probe behavioral risk for SUDs. The longitudinal study will investigate the effects of early stress and genetic variants on the maturation of brain functional responses to these same tasks. It will also begin to address the influence of drug use on brain development, as well as the predictive value of early brain functional responses in identifying risk for later substance abuse problems. The proposed training and research activities will provide a solid foundation for the candidate to become an independent investigator specializing in longitudinal developmental neuroimaging studies of risk for SUDs.

描述（由申请人提供）： 该指导研究科学家发展奖将支持候选人利用纵向发育神经影像学来研究物质使用障碍（SUD）的遗传风险，建立独立的研究生涯。职业发展培训领域包括： 1）功能磁共振成像（fMRI）方法和统计分析，特别关注儿科神经影像； 2）复杂行为的遗传基础，以及基因-大脑-行为关系； 3）关于精神病理学风险的理论构建； 4）纵向研究方法和统计分析。拟议的研究计划是利用功能磁共振成像检查特定遗传多态性和早期生活压力对儿童 SUD 风险神经相关因素的影响。早年的行为和情绪失调是晚年 SUD 的有力预测因素。一个复杂的神经元回路，包括纹状体、杏仁核和前额皮质，调节这些过程。拟议的研究计划将从正在进行的 UM/MSU 纵向研究 (R37 AA07065) 中的 7 至 11 岁男孩和女孩 (n=60) 样本中对这些神经系统进行横断面研究，并在该样本中纵向研究 2-年间隔。这项横断面研究将调查早期压力和基因变异（COMT、SLC6A4、MAO-A、TPH、BDNF）对大脑对旨在探测 SUD 行为风险的任务的反应的影响以及它们之间的相互作用。这项纵向研究将调查早期压力和遗传变异对大脑对这些相同任务的功能反应成熟的影响。它还将开始解决吸毒对大脑发育的影响，以及早期大脑功能反应在识别后期药物滥用问题风险方面的预测价值。拟议的培训和研究活动将为候选人成为专门从事 SUD 风险纵向发育神经影像研究的独立研究者奠定坚实的基础。