HIV AIDS and Opportunistic Infections

HIV 艾滋病和机会性感染

• 批准号: 7088831
• 负责人: Vinayaka R. Prasad
• 金额: $ 23.9万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-06-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7088831
• 关键词: HIV; AIDS; Opportunistic; Infections

DESCRIPTION (provided by applicant): This is a competitive renewal, for years 11 - 15, of an institutional HIV/AIDS training grant. This training grant serves as the means of providing high quality training for advanced pre- and post-doctoral candidates who wish to pursue independent careers in HIV/AIDS-related topics. The program will offer broad training in modern biology including virological, biochemical, genetic, molecular, cell biological and structural approaches. AIDS-related research in this institute conforms to the principle that successful AIDS research requires multiple investigators pursuing closely related issues in AIDS. This training grant is a focal point for training and research by 18 faculty from four basic science, and three clinical departments: Microbiology and Immunology, Molecular Genetics, Pathology, Biochemistry, Pediatrics, Medicine, and Epidemiology and Population Health. All training faculty of this program are members of the Einstein/MMC Center for AIDS Research, which provides centralized, essential core facilities required for AIDS research such as Virology, Flow cytometry, Biohazard, Clinical and Immunology cores. Our predoctoral training program operates within the guidelines of the Sue Golding Graduate School. This includes a centralized recruitment program, a well coordinated admissions process, a core of basic courses followed by specialized courses in Virology, Microbial Pathogenesis and Immunology supplemented with journal clubs, work-in-progress meetings and seminars by outside speakers for each pre- and postdoctoral trainee. An essential element is the intensive research program within each laboratory with close supervision throughout. Our program also includes training in specialized instrumentation and new technologies as needed for the specific research project: Flow cytometry, Hybridoma, transgenic mouse, gene knockout and stem cell technology, x-ray crystallography and molecular modeling, peptide synthesis and protein sequencing, oligonucleotide synthesis and DNA sequencing and the microarray technology. In the renewal application, featuring an expanded HIV/AIDS faculty, we will continue an integrated approach to HIV and opportunistic infection research with a combined emphasis including molecular and clinical studies of HIV and three major opportunistic pathogens (M. tuberculosis, C. neoformcms and T. gondii), development of vaccine and immune therapies and murine models to study the pathogenesis of AIDS.

描述（由申请人提供）：这是机构艾滋病毒/艾滋病培训补助金的11 - 15年的竞争性更新。这项培训补助金是为希望从事与艾滋病毒/艾滋病有关的主题独立职业的高级前后候选人提供高质量培训的手段。该计划将在现代生物学方面提供广泛的培训，包括病毒学，生化，遗传，分子，细胞生物学和结构方法。该研究所与艾滋病相关的研究符合以下原则：成功的艾滋病研究需要多个研究人员在艾滋病中追求密切相关的问题。这项培训补助金是来自四个基础科学的18位教职员工的培训和研究的焦点，以及三个临床部门：微生物学和免疫学，分子遗传学，病理学，生物化学，儿科，医学以及流行病学和人群健康。该计划的所有培训学院均为爱因斯坦/MMC艾滋病研究中心的成员，该中心提供了诸如病毒学，流式细胞仪，生物危害，临床和免疫学核心等艾滋病研究所需的集中式核心设施。我们的培训前培训计划在Sue Golding研究生院的指南中运作。其中包括一个集中式招聘计划，一个协调良好的入学过程，基本课程的核心，然后是病毒学，微生物发病机理的专业课程以及补充期刊俱乐部的免疫学，外部演讲者的活动会议和研讨会，每个前言语前和博士后培训者。一个基本要素是每个实验室内的密集研究计划，并在整个实验室进行密切监督。我们的计划还包括针对特定研究项目所需的专用仪器和新技术培训：流式细胞术，杂交瘤，转基因小鼠，基因敲除和干细胞技术，X射线晶体学和分子建模，肽的综合和蛋白质测序，蛋白质测序，寡核苷酸的合成和DNA测序和DNA测序和Microarray Technology。在续签应用程序中，我们将继续采用综合的艾滋病毒和机会感染研究方法，其中包括艾滋病毒的分子和临床研究，包括艾滋病毒和三种主要的机会病原体（M. tuberculculisis，C。neooformcms和c。neooformcms和t. gondii），疫苗和inishune therepies and Murine and Murine and Murine and Murine and Murine and Murine and Murine and Murine and Murine and Murine and Murine and Murine and Murine and Murine and Murine and Murine and Murine and Murine and Murine and Murine and Murine and Murine and Murine。