Very High Resolution SPECT/CT System

甚高分辨率 SPECT/CT 系统

• 批准号: 6784340
• 负责人: LING-JIAN MENG
• 金额: $ 18.44万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-15 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6784340
• 关键词: X ray; bioengineering /biomedical engineering; bioimaging /biomedical imaging; biomedical equipment development; computed axial tomography; disease /disorder model; gamma radiation; image processing; iodine; neoplasm /cancer; phantom model; radionuclides; scintillation counter; single photon emission computed tomography

DESCRIPTION (provided by applicant): The long term goal of this investigation is to develop a small animal SPECT/CT system that provides a significantly improved imaging performance for small animal models of human diseases with I-125 labeled radiotracers. This development makes use of the recently developed and commercially available Electron Bombarded Charge Coupled Device (EBCCD) technology. Compared with the position sensitive photomultiplier (PSPMT) tubes, it offers an order of magnitude improvement in the spatial resolution for detecting low energy gamma rays. This advance in detector technology may be translated into better estimates of the tracer distributions within test animals. In order to achieve this long-term goal, two specific aims are proposed for the project period: 1. Experimentally demonstrate that the EBCCD device is capable of providing a significant improved spatial resolution for detecting low energy gamma rays from 1-125. The expected key performances include (1) an intrinsic spatial resolution of ~0. 1mm, (2) a signal level of ~5 photoelectrons for gamma rays with 30keV and (3) a total noise level significantly lower than the signal induced by 1-125 gamma rays. 2. Demonstrate that the very high resolution of the EBCCD device can be translated into much improved imaging performance for SPECT/CT imaging. We will to show this improvement in two ways. First, we would like to construct a prototype SPECT/CT system that will be tested in experimental performance assessments. Second, we would like to compare the actual system performance with that predicted analytically with theoretical tools previously developed in the University of Michigan. This would help us to gain insights into the requirements and suitable design tools for future development of small animal imaging systems. This investigation will also create opportunities for collaborative studies with investigators of the University of Michigan's SAIRP, the Department of Veterans Affairs Healthcare System at Ann Arbor and CERN.

描述（由申请人提供）： 这项研究的长期目标是开发一种小动物 SPECT/CT 系统，利用 I-125 标记的放射性示踪剂，为人类疾病的小动物模型提供显着改善的成像性能。该开发利用了最近开发的商用电子轰击电荷耦合器件 (EBCCD) 技术。与位置敏感光电倍增管（PSPMT）相比，它在探测低能伽马射线的空间分辨率方面提高了一个数量级。探测器技术的进步可以转化为对测试动物内示踪剂分布的更好估计。为了实现这一长期目标，项目期间提出了两个具体目标： 1. 实验证明，EBCCD 装置能够显着提高空间分辨率，用于检测 1-125 的低能伽马射线。预期的关键性能包括 (1) 内在空间分辨率约为 0。 1mm，(2) 30keV 伽马射线的信号水平约为 5 个光电子，(3) 总噪声水平显着低于 1-125 伽马射线引起的信号。 2. 证明 EBCCD 设备的极高分辨率可以转化为 SPECT/CT 成像的显着改进的成像性能。我们将以两种方式展示这一改进。首先，我们想要构建一个原型 SPECT/CT 系统，该系统将在实验性能评估中进行测试。其次，我们想将实际系统性能与密歇根大学先前开发的理论工具分析预测的系统性能进行比较。这将帮助我们深入了解小动物成像系统未来开发的要求和合适的设计工具。 这项调查还将为与密歇根大学 SAIRP、安娜堡退伍军人事务医疗系统部和 CERN 的研究人员进行合作研究创造机会。

项目成果

Exploring the limiting timing resolution for large volume CZT detectors with waveform analysis.

通过波形分析探索大体积 CZT 探测器的极限定时分辨率。

• DOI: 10.1016/j.nima.2005.04.076
• 发表时间: 2005-09-11
• 期刊: IEEE transactions on nuclear science
• 影响因子: 1.8
• 作者: Ling;Zhong He
• 通讯作者: Zhong He

An Intensified EMCCD Camera for Low Energy Gamma Ray Imaging Applications.

适用于低能伽马射线成像应用的增强型 EMCCD 相机。

• 发表时间: 2006-08
• 影响因子: 1.8
• 作者: Meng; L J
• 通讯作者: L J

Design and Feasibility Study of a Single Photon Emission Microscope System for Small Animal I-125 Imaging.

用于小动物 I-125 成像的单光子发射显微镜系统的设计和可行性研究。

• 发表时间: 2006-06
• 影响因子: 1.8
• 作者: Meng, L J;Clinthorne, N H;Skinner, S;Hay, R V;Gross, M
• 通讯作者: Gross, M

An Ultrahigh Resolution SPECT System for I-125 Mouse Brain Imaging Studies.

用于 I-125 小鼠脑成像研究的超高分辨率 SPECT 系统。

• 发表时间: 2009-03-01
• 作者: Meng, L. J.;Fu, G.;Roy, E. J.;Suppe, B.;Chen, C. T.
• 通讯作者: Chen, C. T.

SPEM: a state-of-the-art instrument for high resolution molecular imaging of small animal organs.

SPEM：一种最先进的小动物器官高分辨率分子成像仪器。

• 发表时间: 2012-04
• 作者: Reis, Marilia Alves dos;Mejia, Jorge;Batista, Ilza Rosa;Barboza, Marycel Rosa Felisa Figols de;Nogueira, Solange Amorim;Wagner, Jairo;Cabral, Francisco Romero;Davoglio, Petrick Marcellus Victorio Mendonça;Abílio, Vanessa Costhek;Fu, Geng;Li, Nan
• 通讯作者: Li, Nan