Musculoskeletal Tissue Repair and Regeneration

肌肉骨骼组织修复和再生

• 批准号: 7059492
• 负责人: CATO T. LAURENCIN
• 金额: $ 17.04万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7059492
• 关键词: Musculoskeletal; Tissue; Repair; Regeneration

DESCRIPTION (provided by applicant): We propose a new postdoctoral training program that offers a choice of research areas to Ph.D.s and to M.D.s with an interest in the diverse area of musculoskeletal tissue repair and regeneration. We offer trainees a broad level of expertise in research and instruction based on the research, educational, and clinical experiences of the faculty who serve as preceptors in this program. Trainees in this program will become expert in their knowledge of bio-matrices and their cell and tissue interactions and will translate molecular principles of cell-matrix and growth factor interactions to the alleviation of human disease, musculoskeletal injuries and tissue regeneration. These themes are ripe for an inventive approach to address challenging issues in a practical way in order to advance technology and fundamental knowledge for future therapeutic applications to musculoskeletal tissues. Training faculty from a variety of departments including Orthopedic Surgery, Biomedical Engineering, Medicine, Neurological Surgery, Biochemistry and Molecular Genetics, and Surgery will provide the primary research training for postdoctoral trainees recruited into the program. Training faculty research laboratories are well funded and supplemented by a University wide shared instrumentation and core facility system that is supported by the Dean of the School of Medicine. A number of the preceptors have published together and are currently involved in the co-preceptorship of post-doctoral trainees and have current or pending grant applications in which they serve as co-investigators. The areas of research expertise of the faculty preceptors, their research interactions and collaboration, sets them in four thematic groupings: tissue engineering, spine injuries, joint degeneration and macromolecular interactions. Program Administration through the Department of Orthopaedic Surgery will provide the assistance to recruit trainees and to implement the program. Goals of this program are the involvement of trainees in 1) a rigorous initial selection process 2) Development of research skills across traditional departmental boundaries 3) Participation of trainees in the pursuit of funding, presenting at high level scientific meetings and publication of their works as primary authors. The preceptors of this program have demonstrated success at developing scientists for academic research and teaching and it is expected that those trained in this setting are candidates likely to select a career in academia.

描述（由申请人提供）： 我们提出了一项新的博士后培训计划，该计划为博士学位和M.D.S提供了一系列研究领域，并对肌肉骨骼组织修复和再生的多元化领域感兴趣。我们为受训者提供了基于作为该计划的教师的研究，教育和临床经验的研究和教学方面的广泛专业知识。该计划中的受训者将成为他们对生物诊断及其细胞和组织相互作用的知识的专家，并将将细胞矩阵的分子原理和生长因子相互作用转化为减轻人类疾病，肌肉骨骼损伤和组织再生的减轻。这些主题是一种以实际方式来解决挑战性问题的创造性方法的成熟，以促进技术和基本知识，以促进对肌肉骨骼组织的未来治疗应用。来自各个部门的培训学院，包括骨科手术，生物医学工程，医学，神经外科手术，生物化学和分子遗传学以及手术，将为招募参与该计划的博士后学员提供主要的研究培训。培训教师研究实验室的资金良好，并由大学广泛的共享仪器和核心设施系统得到了补充，该工具和核心设施系统得到了医学院院长的支持。许多主持人已经一起发布，目前参与了博士后学员的共同疗程，并具有当前或未决的赠款申请，它们是他们作为共同投资者的申请。教职员工的研究专业知识领域，他们的研究相互作用和协作，将它们分为四个主题分组：组织工程，脊柱损伤，关节退化和大分子相互作用。通过骨科手术部的计划管理将为招募受训者提供帮助并实施该计划。该计划的目标是学员参与1）严格的初始选择过程2）跨传统部门界限的研究技能的发展3）受训者参与追求资金，在高级科学会议上提出，并将其作为主要作者的作品出版。该计划的主持人在开发学术研究和教学的科学家方面取得了成功，预计在这种情况下接受培训的人是可能在学术界选择职业的候选人。