300 MHz NMR SPECTROMETER

300 MHz 核磁共振波谱仪

• 批准号: 6580578
• 负责人: Robert W Curley
• 金额: $ 19.5万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2004-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6580578
• 关键词: biomedical equipment purchase; chemical structure function; drug design /synthesis /production; drug discovery /isolation; drug screening /evaluation; nuclear magnetic resonance spectroscopy

DESCRIPTION (provided by applicant): Research in the areas of drug design and discovery relies heavily on spectroscopic instruments used to determine the chemical structure, conformation, and dynamic behavior in solution of the molecules being studied. At present and for the foreseeable future, one of the most important spectroscopic tools used to assess these structural features in the development of new synthetic drugs and the isolation of potential drugs from natural sources is nuclear magnetic resonance (NMR) spectroscopy. The faculty members, students, and research personnel of the Division of Medicinal Chemistry and Pharmacognosy in the College of Pharmacy of The Ohio State University have a long tradition of shared use of NMR spectrometers in creative ways to facilitate nationally recognized research in drug design and discovery. This NCRR Shared Instrumentation grant application requests funds for the purchase of the Bruker Avance 300 FT/NMR spectrometer system with 7.05 Tesla superconducting magnet, rf transmitter system with X-nucleus observe and decouple capabilities, digital acquisition control system, computer workstation and software, digital variable temperature control unit, and a 5 mm broadband observe probe. The requested 300 MHz NMR will replace a 15-year old 250 MHz Bruker AC250 spectrometer that has served as the "workhorse" instrument for handling large numbers of shorter duration NMR experiments in our shared instrument facility in the College of Pharmacy. The 250 MHz spectrometer provided us with unusually reliable service over the years, but the AC250 has become more obsolete, unreliable and nearly impossible to repair due to diminishing parts' availability. This request for a 300 MHz NMR spectrometer system represents the most cost effective, capable spectrometer to accommodate our growing local user group of about 45 individuals, consisting of medicinal chemistry faculty members, graduate students, and post-doctoral researchers.

描述（由申请人提供）：药物设计和发现领域的研究在很大程度上依赖于用于确定所研究分子溶液中的化学结构、构象和动态行为的光谱仪器。目前和可预见的未来，用于评估新合成药物开发和从天然来源中分离潜在药物的这些结构特征的最重要的光谱工具之一是核磁共振（NMR）光谱。俄亥俄州立大学药学院药物化学与生药学系的教职员工、学生和研究人员有着以创造性方式共享使用核磁共振波谱仪的悠久传统，以促进国家认可的药物设计和发现研究。此 NCRR 共享仪器拨款申请要求资金用于购买配备 7.05 Tesla 超导磁体的 Bruker Avance 300 FT/NMR 波谱仪系统、具有 X 核观察和解耦功能的射频发射器系统、数字采集控制系统、计算机工作站和软件、数字可变温度控制单元和5毫米宽带观察探头。所要求的 300 MHz NMR 将取代已有 15 年历史的 250 MHz Bruker AC250 光谱仪，该光谱仪一直是药学院共享仪器设施中处理大量较短持续时间 NMR 实验的“主力”仪器。多年来，250 MHz 光谱仪为我们提供了异常可靠的服务，但 AC250 已经变得更加过时、不可靠，并且由于零件可用性的减少而几乎无法维修。对 300 MHz NMR 波谱仪系统的需求代表了最具成本效益、功能强大的波谱仪，可以满足我们不断增长的约 45 人的本地用户群体，其中包括药物化学教员、研究生和博士后研究人员。