Seizure Location Using Signal Processing Techniques

使用信号处理技术进行癫痫发作定位

• 批准号: 7099427
• 负责人: Catherine A Schevon
• 金额: $ 16.71万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7099427
• 关键词: Macaca; biomarker; brain disorder diagnosis; brain electrical activity; clinical research; data collection methodology /evaluation; diagnosis design /evaluation; diagnosis quality /standard; electrodes; electroencephalography; electrophysiology; magnetic resonance imaging; method development; molecular site; neurophysiology; partial seizure; statistics /biometry

DESCRIPTION (provided by applicant): A program of research and career development has been designed for the P.I. to devise new methods for interpreting long-term intracranial electroencephalograms (EEG) of epilepsy patients. Intracranial monitoring has been established as the most specific method of seizure localization prior to resective epilepsy surgery. Existing methods of interpretation have proven inadequate for seizures originating in neocortex. Quantitative techniques drawn from the field of signal processing can be applied to EEG signals to reveal spatio- temporal patterns that provide clues to the seizure origin. Mapping of abnormalities in neuronal network organization in the brains of epilepsy patients will be performed, with validation of abnormal findings by evaluation of synchrony and current source density analysis in comparable recordings obtained from normal macaque monkeys. These findings, together with the behavior of EEG recordings during epileptic seizures, will be studied to define ictal EEG patterns and gain insight into their underlying mechanisms of epileptogenesis. This will provide a framework for the formulation of methods for the accurate interpretation of intracranial recordings. A formal training program has been designed for the P.I. specifically tailored to her academic needs, complementing her prior clinical training and experience in engineering and mathematics. This will include: mentoring by experts in electrophysiology, signal processing, primate studies and clinical epileptology, and course work in biomedical signal processing, statistics and research ethics. The goal of this coordinated program of research and training is to complete the preparation of the P.I. for a career as an independent researcher, with the skills to perform multidisciplinary collaborative investigation and a developed capacity to define new directions for research in electrophysiology and epilepsy.

描述（由申请人提供）：为P.I.设计了研究和职业发展计划。设计新方法来解释癫痫患者的长期颅内脑电图（EEG）。颅内监测已被确定为诊断性癫痫手术之前最具体的癫痫发作定位方法。现有的解释方法已证明源自新皮层的癫痫发作不足。从信号处理领域绘制的定量技术可以应用于脑电图信号，以揭示时空模式，这些时空模式为癫痫发作起源提供了线索。将通过评估同步和当前的源密度分析来验证异常发现的神经元网络组织中异常的映射。这些发现以及癫痫发作期间脑电图记录的行为将进行研究，以定义发作性脑电图模式并深入了解其潜在的癫痫发生机制。这将提供一个框架，用于制定方法，以准确解释颅内记录。已为P.I.设计了正式的培训计划特别适合她的学术需求，以补充她先前的临床培训以及工程和数学方面的经验。这将包括：由电生理学专家指导，信号处理，灵长类动物研究和临床癫痫学以及生物医学信号处理，统计和研究伦理方面的课程工作。这项协调的研究和培训计划的目的是完成P.I.的准备。在作为独立研究人员的职业生涯中，具有进行多学科合作调查的技能，并具有确定电生理学和癫痫研究新方向的发达能力。