Treatment of Adolescents with Anorexia Nervosa

青少年神经性厌食症的治疗

• 批准号: 7051954
• 负责人: JAMES D LOCK
• 金额: $ 42.82万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-01 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7051954
• 关键词: adolescence (12-20); anorexia nervosa; behavioral /social science research tag; clinical research; ego /superego /id; emotional dependency; family structure /dynamics; family therapy; human subject; human therapy evaluation; longitudinal human study; patient oriented research; psychological tests; psychotherapy; self concept; weight gain; adolescence (12-20); anorexia nervosa; behavioral /social science research tag; clinical research; ego /superego /id; emotional dependency; family structure /dynamics; family therapy; human subject; human therapy evaluation; longitudinal human study; patient oriented research; psychological tests; psychotherapy; self concept; weight gain

DESCRIPTION (provided by applicant): Anorexia Nervosa (AN) is a serious psychological condition with a prevalence estimated at 0.48% among adolescent females between 15-19 years. In adolescents, the illness severely affects physical, emotional, and social development. To date, there are no large-scale treatment studies of adolescents with AN. Smaller scale studies, however, suggest that a specific type of family-based treatment (FT) is an effective approach to adolescent onset AN. This multi-site study aims to compare this specific family therapy (FBT) with ego oriented individual psychotherapy (EOIT) to determine which treatment is more efficacious. The study has two specific aims: (1) To compare the relative efficacy of FBT and EOIT in adolescents with AN. We will specifically examine weight gain, psychological concerns about weight and shape and changes in family functioning. (2) To examine potential predictors, mediators and moderators of outcome. To accomplish these aims the following study is proposed: at two centers (60 per center), 120 adolescents between the ages of 12-18 meeting DSM-IV criteria for AN will be randomly assigned to one of two treatment groups: 1) FBT (manualized) for 24 planned patient hours for 12 months; or 2) EOIT (manualized) for 24 planned patient hours over 12 months. All patients will be followed for 1 year after the end of treatment. Assessment will occur at baseline, end of treatment, and six months and one-year follow-up. Primary outcome will be weight change. Secondary outcomes will be changes in weight and shape concerns as measured by the Eating Disorder Examination.

描述（由申请人提供）：神经性厌食症（AN）是一种严重的心理状况，在15-19岁之间的青少年女性中估计患病率为0.48％。在青少年中，疾病严重影响身体，情感和社会发展。迄今为止，还没有针对青少年的大规模治疗研究。但是，较小的规模研究表明，一种特定类型的基于家庭的治疗（FT）是对青少年发作的有效方法。这项多站点研究旨在将这种特定的家庭疗法（FBT）与面向自我的个人心理治疗（EOIT）进行比较，以确定哪种治疗方法更有效。 该研究具有两个具体的目的：（1）比较FBT和EOIT在An的青少年中的相对效果。我们将特别检查体重增加，对体重和形状的心理问题以及家庭功能的变化。 （2）检查结果的潜在预测因素，介体和调节因子。 为了实现这些目的，提出了以下研究：在两个中心（60个中心），120名青少年在12-18岁之间遇到DSM-IV标准的青少年将随机分配给两个治疗组之一：1）FBT（1）fbt（手动化）为24个计划的患者小时12个月；或2）EOIT（手动）在12个月内有24个计划的患者小时。 治疗结束后，所有患者将遵循1年。评估将在基线，治疗结束以及六个月和一年的随访中进行。主要结果将是体重的变化。次要结果将是通过饮食失调检查衡量的体重和形状关注的变化。