Effect of Ambient Particles on Acute Stroke Onset

环境颗粒物对急性中风发作的影响

• 批准号: 6939093
• 负责人: MURRAY A MITTLEMAN
• 金额: $ 21.58万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6939093
• 关键词: air pollution; air sampling /monitoring; cardiovascular disorder epidemiology; cardiovascular disorder risk; clinical research; disease /disorder onset; environmental exposure; human subject; nervous system disorder epidemiology; particle; stroke

Stroke is a leading cause of long-term disability in the US and the third leading cause of death after heart disease and cancer. The identification of triggers of stroke onset is of significant public health interest. Many epidemiologic studies have found an association between short-term increases in particulate air pollution and cardiovascular morbidity and mortality. These effects are likely mediated by neural, hematologic, and inflammatory responses to inhaled particles. Exposure to particulate matter may also increase the risk of ischemic stroke. Recent studies using administrative databases have reported equivical results. Accordingly, the goal of this Project is to quantitatively evaluate the association between short-term increases in ambient particulate matter and the risk of acute ischemic stroke. Specifically, we will evaluate: 1) the association between short-term increases in particulate matter and the risk of acute ischemic stroke, 2) the time course of this effect, 3) the specific constituents of ambient particulate matter to which the effect is most likely attributable, and 4) variation in effect magnitude by etiological subtype of ischemic stroke. To accomplish these aims we will use the services and expertise of the PPG Cores and will apply the case-crossover methodology to the study of 1200 patients hospitalized with acute ischemic stroke. Even though the magnitude of any effect is expected to be small, given the large number of people simultaneously at risk for stroke and exposed to urban air pollution, the attributable risk may be quite significant. Clarifying the impact of particulate air pollution on stroke onset is important for regulatory agencies. Additionally, information about the time course of the effect and identification of important particle constituents may provide insight into the mechanisms of particulate-induced cardiovascular events.

中风是美国长期残疾的主要原因，也是仅次于心脏病和癌症的第三大死亡原因。识别中风发作的触发因素具有重大的公共卫生利益。许多流行病学研究发现，颗粒空气污染的短期增加与心血管发病率和死亡率之间存在关联。这些作用可能是由对吸入颗粒的神经，血液学和炎症反应介导的。暴露于颗粒物也可能增加缺血性中风的风险。使用行政数据库的最新研究报告了等效结果。因此，该项目的目的是定量评估周围颗粒物物质的短期增加与急性缺血性中风的风险之间的关联。具体来说， 我们将评估：1）颗粒物物质的短期增加与急性缺血性中风的风险之间的关联，2）这种效果的时间过程，3）环境颗粒物的特定组成部分最有可能归因于效果，而4）4）效应效果量的变化因情绪亚型的效果级变化。为了实现这些目标，我们将使用PPG核心的服务和专业知识，并将病例分解方法应用于1200名患有急性缺血性中风的患者。尽管预计任何效果的大小都将很小，但鉴于大量的人同时有中风风险并受到城市空气污染的影响，但可归因的风险可能非常重要。澄清颗粒空气污染对中风发作的影响对于调节机构很重要。另外，有关重要粒子效果和识别的时间过程的信息 成分可能会深入了解颗粒引起的心血管事件的机制。