Nanotechnology-based Theranostic Technology for Bone Tissue Engineering

基于纳米技术的骨组织工程治疗诊断技术

• 批准号: 7981587
• 负责人: Balaji Sitharaman
• 金额: $ 235.5万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7981587
• 关键词: Acoustics; Aging; Award; Bed rest; Bone Regeneration; Bone Tissue; Carbon Nanotubes; Cell Transplants; Development; Diagnostic; Disease; Electromagnetics; Engineering; Foundations; Frail Elderly; Future; General Population; Gold; Healed; Health; Image; Investigation; Menopause; Modality; Monitor; Musculoskeletal; Nanotechnology; Natural regeneration; Osteogenesis; Pathology; Physiologic pulse; Process; Site; Spinal cord injury; Stem cells; Stimulus; Technology; Therapeutic; Three-Dimensional Imaging; Time; Tissue Engineering; Trauma; Travel; Underserved Population; United States National Institutes of Health; Vascularization; Wheelchairs; abstracting; base; bone loss; cost; experience; healing; imaging modality; innovation; insight; nanomaterials; nanoparticle; nanosecond; next generation; physical property; repaired; skeletal; technology development; tissue support frame; user-friendly; Acoustics; Aging; Award; Bed rest; Bone Regeneration; Bone Tissue; Carbon Nanotubes; Cell Transplants; Development; Diagnostic; Disease; Electromagnetics; Engineering; Foundations; Frail Elderly; Future; General Population; Gold; Healed; Health; Image; Investigation; Menopause; Modality; Monitor; Musculoskeletal; Nanotechnology; Natural regeneration; Osteogenesis; Pathology; Physiologic pulse; Process; Site; Spinal cord injury; Stem cells; Stimulus; Technology; Therapeutic; Three-Dimensional Imaging; Time; Tissue Engineering; Trauma; Travel; Underserved Population; United States National Institutes of Health; Vascularization; Wheelchairs; abstracting; base; bone loss; cost; experience; healing; imaging modality; innovation; insight; nanomaterials; nanoparticle; nanosecond; next generation; physical property; repaired; skeletal; technology development; tissue support frame; user-friendly

DESCRIPTION (Provided by the applicant) Abstract: The principal objective of the studies detailed in this application for the NIH Director's New Innovator Award is to engineer the next generation of nanotechnology-based theranostic (diagnostic + therapeutic) technology that will facilitate non-invasive imaging, and at the same time enable targeted activation of the healing process at sites of hampered musculoskeletal repair. Bone loss, due to trauma, disease, aging, or menopause is an increasingly serious health problem, and the emerging field of bone tissue engineering seeks to develop strategies to ameliorate focal bone loss. The proposed theranostic technology harnesses the physical properties of innovative multifunctional nanomaterials (single-walled carbon nanotubes and gold nanoparticles), and an acoustic wave phenomenon induced by nanosecond electromagnetic pulses known as the photoacoustic (PA) effect. The PA-based imaging approach exploits the combined intrinsic and extrinsic photoacoustic contrast between regenerating tissues and scaffolds or transplanted cells containing nanoparticles to non-invasively image (spatially and temporally) de novo bone formation and neo- vascularization. The unique and innovative approach for photoacoustic treatment involves a biophysical stimulus to bias the differentiation of progenitor cells towards controlled osteoblastogenesis thereby enhancing the quality and quantity of bone formation in the exposed region. The investigations will provide new insights, and lay the scientific foundation for future development of an integrated imaging and therapeutic technology to monitor and treat specific skeletal pathologies. Upon complete development, this technology could be made widely available to the general public, including medically under-served populations since, as an imaging modality, it will be non-ionizing, user-friendly and cost less than other 3D imaging modalities used to monitor bone regeneration; as a therapeutic modality, it would be suitable for subjects able or unable to stand (e.g., frail elderly, spinal cord injury, confined to wheelchairs or bed-rest, experience space travel) during treatment. Public Health Relevance: Bone loss, due to trauma, disease, aging, or menopause is an increasingly serious health problem. This proposal will provide new insights, and lays the scientific foundation for future development of a theranostic (integrated therapeutic and diagnostic) technology for combined non-invasive imaging and treatment in a single setting of specific skeletal pathologies; ultimately, with this proof of principal defined, there is the possibility of development for a wider range of injuries or diseases which require targeted detection, and treatment. Upon complete development, this technology could be made widely available to the general public, including medically under-served populations since, as an imaging modality, it will be non-ionizing, userfriendly and costs less than other 3D imaging modalities used to monitor bone regeneration; as a therapeutic modality, it would be suitable for subjects able or unable to stand (e.g., frail elderly, spinal cord injury, confined to wheelchairs or bed-rest, experience space travel) during treatment for osteo-integration, fracture healing, osteoporosis and similar diseases.

描述（申请人提供） 摘要：该NIH导演的新创新者奖中详细介绍的研究的主要目标是授予下一代基于纳米技术的基于纳米技术的技术（诊断 +治疗性）技术，该技术将促进非侵入性成像，同时促进对hampered Muscempeleskeletskeletskeletskeletskeletskeletskelet seplectal muscelets的愈合过程的靶向激活。由于创伤，疾病，衰老或更年期，骨质流失是一个日益严重的健康问题，骨组织工程的新兴领域旨在制定改善局灶性骨骼损失的策略。拟议的Theranotic技术利用创新的多功能纳米材料（单壁碳纳米管和金纳米颗粒）的物理特性，以及由纳米秒电磁脉冲诱导的声波现象，称为光播（PA）效应。基于PA的成像方法利用了再生组织和脚手架或含有纳米颗粒的移植细胞之间的内在和外部光声对比，可将纳米颗粒的单位形成（在空间和时间上）从头形成（从空间和时间上）从头形成和新脉管化。光声处理的独特而创新的方法涉及生物物理刺激，以使祖细胞的分化偏向于控制的成骨细胞生成，从而增强了暴露区域的骨形成的质量和数量。调查将提供新的见解，并为未来开发综合成像和治疗技术的发展奠定了科学基础，以监测和治疗特定的骨骼病理。完整开发后，该技术可以广泛地向公众广泛使用，包括医学不足的人群，因为作为成像方式，它将是不可接化的，用户友好的，并且成本低于其他用于监测骨骼再生的3D成像方式；作为一种治疗方式，它适用于能够站立或无法站立的受试者（例如，脆弱的老年人，脊髓损伤，限制在轮椅或床位上，在治疗过程中体验太空旅行）。 公共卫生相关性：由于创伤，疾病，衰老或更年期，骨质流失是一个日益严重的健康问题。该提案将提供新的见解，并为未来（综合治疗和诊断）技术的未来开发奠定了科学基础，以在特定的骨骼病理的单一设置中进行联合非侵入性成像和治疗。最终，有了这种主体定义的证明，需要开发更广泛的伤害或疾病，需要有针对性的检测和治疗。完整开发后，这项技术可以广泛地向公众广泛使用，包括医疗服务不足的人群，因为作为成像方式，它将是非离子化，用户友好的，并且成本低于其他用于监测骨骼再生的3D成像方式；作为一种治疗方式，它适用于能够或无法站立的受试者（例如，老年人，脊髓损伤，局限于轮椅或床位，体验太空旅行），用于骨整合，骨折愈合，骨质疏松症和类似的疾病。