Hippocampal activity and pathology in APOE-4 subjects

APOE-4 受试者的海马活动和病理学

• 批准号: 6948464
• 负责人: Meredith Nicole Braskie
• 金额: $ 3.82万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2006-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6948464
• 关键词: Alzheimer' s disease; amyloid proteins; apolipoprotein E; bioimaging /biomedical imaging; brain disorder diagnosis; brain imaging /visualization /scanning; clinical research; computer assisted diagnosis; computer program /software; early diagnosis; functional magnetic resonance imaging; genetic susceptibility; hippocampus; human middle age (35-64); human subject; memory disorders; neurofibrillary tangles; pathologic process; positron emission tomography; predoctoral investigator; psychological tests; sign /symptom; statistics /biometry

DESCRIPTION (provided by applicant): The goal of this proposal is to explore the relationship between neurofibrillary tangles and amyloid plaques, the hallmarks of Alzheimer's disease (AD) and the hippocampal response during a memory-taxing task in young (aged 45 to 60) participants who have a genetic risk for, but not yet any symptoms of AD. It is also to attempt to identify the earliest signs of the disease, and predictive factors for developing the disease. Volunteers, who have the APOE-4 allele, a known risk factor for AD, and their age-matched counterparts without APOE-4, will undergo functional magnetic resonance imaging while learning new associations, a task that previously has been shown to activate the hippocampus. These same subjects will undergo PET scans using FDDNP, a probe that attaches preferentially to amyloid plaques and neurofibrillary tangles and allows them to be imaged. The images will be "unfolded", or portrayed in a two-dimensional field, using a computer application designed for that purpose. This will allow specific activation within the hippocampus to be identified and localized. The PET images and fMRI images will then be superimposed in such a way that it will be possible to determine whether localization of amyloid plaques and neurofibrillary tangles correspond to increases in signal intensity during memory tasks as seen in AD patients.

描述（由申请人提供）： 该提案的目的是探索神经原纤维缠结与淀粉样蛋白斑块，阿尔茨海默氏病的标志（AD）和年轻人（45至60岁）参与者的记忆征税任务期间的海马反应之间的关系，但尚无AD症状的遗传风险。 它还试图确定疾病的最早迹象以及发展疾病的预测因素。具有APOE-4等位基因，已知的AD风险因素以及其年龄匹配的没有APOE-4的志愿者将在学习新关联时进行功能性磁共振成像，这是一项以前已被证明激活海马的任务。这些相同的受试者将使用FDDNP进行PET扫描，该探针优先附着在淀粉样蛋白斑块和神经原纤维缠结上，并允许它们成像。这些图像将“展开”，或使用为该目的设计的计算机应用程序在二维字段中描绘。这将允许在海马中识别和定位海马内的特定激活。然后，将叠加PET图像和FMRI图像，以确定淀粉样蛋白斑块和神经原纤维缠结的定位是否对应于AD患者的记忆任务期间信号强度的增加。