Selective and Sequential Catalysed Depolymerisation of Polyester Plastics

聚酯塑料的选择性和顺序催化解聚

• 批准号: 2608093
• 金额: --
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2608093
• 关键词: Selective; Sequential; Catalysed; Depolymerisation; Polyester

Transitioning to a circular plastics economy is essential for the conservation of resources, retention of material value, and prevention of rampant pollution. Enzymatic plastic degradation, or biological recycling, offers a novel alternative to current mechanical and chemical recycling methods and is a promising option for difficult-to-recycle plastic waste, such a polymer-polymer blends. Directed evolution is a powerful engineering strategy in developing novel plastic degrading enzymes; previous work explored the directed evolution of an active and thermostable PETase. My new work seeks to broaden the current substrate scope of enzymatic plastic degradation to include poly(bisphenol-A) carbonate (BPA-PC), an engineering thermoplastic produced on a million ton per annum scale. BPA-PC is commonly blended with other hydrolytically labile polymers such as PET and PBT, making a highly selective BPA-PC depolymerase an attractive target. To this end, a BPA-PC degrading enzyme has been identified, and a first round of directed evolution is underway.

过渡到循环塑料经济对于资源的保护，保留物质价值以及预防猖is的污染至关重要。酶促塑料降解或生物回收利用，为当前的机械和化学回收方法提供了一种新颖的替代方法，并且是难以生产的塑料废物（例如聚合物聚合物混合物）的一种有前途的选择。定向进化是一种在开发新型塑料降解酶的强大工程策略。先前的工作探索了活动和热稳定的PETASE的定向演变。我的新作品旨在扩大当前的酶塑料降解的底物范围，包括聚（Bisphenol-A）碳酸盐（BPA-PC），这是一种每年一百万吨的工程热塑性塑料。 BPA-PC通常与其他水解不稳定聚合物（例如PET和PBT）混合，使高度选择性的BPA-PC去聚合酶成为有吸引力的靶标。为此，已经确定了BPA-PC降解酶，并且正在进行第一轮的定向进化。