BIOMIMETICALLY DESIGNED INTERFACES & COMPOSITES

仿生设计的界面

• 批准号: 6516584
• 负责人: John J. Mecholsky
• 金额: $ 19.49万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-03-01 至 2005-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6516584
• 关键词: biomaterial compatibility; biomaterial development /preparation; biomaterial evaluation; biomaterial interface interaction; biomaterials; biomimetics; ceramics; chemical bond; composite resins; dental implants; dentin; enamel organ; hydroxyapatites; medical implant science; polymers

The overall objective of this proposal is to develop a protocol for designing bioactive, biomimetic polymer-inorganic composites for replacement of hard tissue in the body such as enamel, dentin and bone. The approach is to study natural composites in order to determine the key properties for structural superiority, to understand the structure-property relationships in biological systems, and to mimic the properties or structures as much as is feasible in developing efficient bioactive designs for structural repair in the body, especially in dental applications. It is proposed to determine the apparent toughness, strength and crack propagation mechanisms in synthetic and natural inorganic-polymer composites in order to develop a methodology for biomedical composite design. This study proposes to select several natural polymer-inorganic composites such as the stone crab chelae and mollusk shell in order to determine the mechanical properties such as fracture toughness, hardness, strength and interface integrity as a function of the micro-structure and macro-structure. In fact, a main focus of this study is a determination of the structure, integrity, and mechanical behavior of the interface between phases. Unique capabilities are available at the University of Florida for the control of the geometry and chemistry of inorganic-organic interfaces. Thus, a concerted effort will be devoted to the identification of the role of the interfaces in various biological structures in order to replicate the behavior in designed composites. Some unique features of the present study are the application of fractographic analysis of failure origins, fractal analysis to characterize the micro-structure on the failure surfaces, and the identification of the chemistry and mechanics of the interfaces. The synthetic composites to be studied include existing bioactive ceramic-polymer composites, collagen-polymer-inorganic composites and proposed composites based on the studies of biological and existing composites. The protocol developed will be useful in the design of hard tissue for the body to aid in the development of replacement parts that are both bioactive and matched in mechanical properties for the replacement tissue. Although these designed composites have a particular emphasis on dental applications, the principles developed should be applicable to a much broader venue.

该提案的总体目标是开发一种方案，用于设计生物活性、仿生聚合物-无机复合材料，以替代体内的硬组织，如牙釉质、牙本质和骨骼。该方法是研究天然复合材料，以确定结构优越性的关键特性，了解生物系统中的结构-特性关系，并尽可能模仿特性或结构，以开发用于结构修复的有效生物活性设计。身体，特别是在牙科应用中。 建议确定合成和天然无机聚合物复合材料的表观韧性、强度和裂纹扩展机制，以开发生物医学复合材料设计方法。 本研究建议选择几种天然聚合物-无机复合材料，例如石蟹螯和软体动物壳，以确定断裂韧性、硬度、强度和界面完整性等机械性能作为微观结构和宏观结构的函数。 事实上，这项研究的主要重点是确定相间界面的结构、完整性和机械行为。 佛罗里达大学拥有独特的能力来控制无机-有机界面的几何形状和化学。 因此，将共同努力识别各种生物结构中界面的作用，以便在设计的复合材料中复制该行为。 本研究的一些独特之处是应用断裂起源分析、分形分析来表征断裂表面的微观结构以及界面化学和力学的识别。 待研究的合成复合材料包括现有的生物活性陶瓷-聚合物复合材料、胶原-聚合物-无机复合材料以及基于生物和现有复合材料研究而提出的复合材料。 开发的协议将有助于身体硬组织的设计，以帮助开发具有生物活性且与替换组织的机械性能相匹配的替换部件。 尽管这些设计的复合材料特别强调牙科应用，但所开发的原理应该适用于更广泛的领域。