DRUG EFFECTS ON ORAL COCAINE-REINFORCED BEHAVIOR

药物对口服可卡因强化行为的影响

• 批准号: 6933593
• 负责人: RICHARD Alden MEISCH
• 金额: $ 12.4万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6933593
• 关键词: Macaca mulatta; amphetamines; behavior test; behavioral /social science research tag; cocaine; craving; drug abuse chemotherapy; drug addiction; nonhuman therapy evaluation; operant conditionings; oral administration; pyrazines; reinforcer; self medication; substance abuse related behavior; Macaca mulatta; amphetamines; behavior test; behavioral /social science research tag; cocaine; craving; drug abuse chemotherapy; drug addiction; nonhuman therapy evaluation; operant conditionings; oral administration; pyrazines; reinforcer; self medication; substance abuse related behavior

The effects of medications on oral cocaine self-administration will be investigated. Specifically, chronic administration of d-amphetamine, modafinil, and atomoxetine will be studied. Six rhesus monkeys will serve as subjects. The oral route will be used for several reasons. Cocaine is abused orally, and importantly intake of cocaine via the oral route is similar to intake of cocaine via the intranasal route. Most studies of drug effects on cocaine self-administration have used the i.v. route; however, it is important to determine if findings obtained with the i.v. route can be extended to other routes. Four studies will be conducted. In all studies treatment drugs will be administered chronically. The first and second studies will use FR and PR schedules, for these have been the most commonly used schedules in i.v. cocaine experiments. One measure of drug effects will be the ratio of responses under the PR schedule to the ratio of responses under the FR schedule. In these two studies drug effects will also be examined on the resumption and extinction of drug reinforced behavior as well as on the maintenance of behavior. The third study will employ a design that separates "drug seeking" and "drug consumption." Thus, in the initial component (an Interlock schedule FR 480, FI30 min schedule), medication effects on behavior can be assessed in the absence of cocaine in the body. The fourth study concerns the selectivity of medication effects. Cocaine and an equally reinforcing saccharin solution will be concurrently available under non independent Variable-Ratio schedules. These schedules generate patterns of responding that result in the concurrent intake of both reinforcers within the same time segments. Importantly the schedules permit variations in the distribution of responding allocated to each reinforcer without necessarily decreasing the total number of reinforcers obtained. The results of the proposed studies will examine the generality of earlier findings with humans and monkeys that d-amphetamine decreases cocaine intake, and the studies will determine the feasibility of using agonist type medications that are currently approved for use in humans.

将研究药物对口服可卡因自我管理的影响。具体而言，将研究长期对D-苯丙胺，莫达非尼和阿托莫西汀的施用。六只恒河猴将充当主题。口服路线将出于多种原因。可卡因被口服滥用，重要的是，通过口腔途径摄入可卡因类似于通过鼻内途径的可卡因摄入。大多数药物对可卡因自我给药的影响的研究都使用了静脉注射。路线;但是，重要的是确定是否使用i.v.路线可以扩展到其他路线。将进行四项研究。在所有研究中，治疗药物将长期服用。第一和第二研究将使用FR和PR计划，因为这些是I.V.中最常用的时间表。可卡因实验。药物效应的一种衡量标准将是PR时间表下的反应与FR计划下的响应之比的比率。在这两项研究中，还将研究药物效应，以恢复和灭绝药物增强行为以及行为的维持。第三项研究将采用将“寻求药物”和“药物消耗”分开的设计。因此，在最初的组件（互锁附表FR 480，FI30分钟时间表）中，在体内没有可卡因的情况下，可以评估对行为的药物影响。第四项研究涉及药物效应的选择性。可卡因和同样增强的糖精溶液将在非独立变量比率计划下同时使用。这些时间表会产生响应模式，从而导致两种增强剂的同时摄入 同时段。重要的是，这些时间表允许在分配给每个增强器的响应分布的情况下变化，而不必减少获得的加固剂总数。拟议的研究的结果将检查与人类和猴子早期发现D-苯丙胺减少可卡因摄入的一般性，这些研究将确定使用当前批准用于人类使用的激动剂类型药物的可行性。