Tea's effect on atherosclerosis pilot study

茶对动脉粥样硬化影响的初步研究

• 批准号: 6947928
• 负责人: MURRAY A MITTLEMAN
• 金额: $ 29.75万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-15 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6947928
• 关键词: affinity chromatography; aorta; atherosclerosis; atherosclerotic plaque; cardiovascular disorder risk; cardiovascular imaging /visualization; chemoprevention; clinical research; diet therapy; flavonoids; human old age (65+); human subject; human therapy evaluation; low density lipoprotein; magnetic resonance imaging; patient oriented research; tea; urinalysis; vascular endothelium; very low density lipoprotein

DESCRIPTION (provided by applicant): Tea is widely thought to have health benefits, particularly on cardiovascular disease (CVD). Our group recently found that intake of 2 or more cups of tea per day was associated with a 44% lower long-term mortality rate than abstention from tea among 1900 patients hospitalized with myocardial infarction. Short-term trials support a benefit of tea on endothelial function, but long-term randomized trials of tea intake on CVD and atherosclerosis are needed to test the effects of tea definitively. We propose a proof-of-principle pilot study of the effect of long-term tea intake on atherosclerosis. From a large hospital-based primary care practice, we will recruit and randomize 30 patients at high risk for CVD to a six-month period of consumption of 3 cups per day of either tea, supplied as black tea solids readily dissolved in hot or cold liquid, or water. We will confirm the polyphenol content of these solids at baseline, and use a single batch of tea throughout the study. At baseline and after 6 months, we will assess aortic atherosclerosis using magnetic resonance imaging, an accurate and reproducible method for measurement of arterial plaque size. We will measure adherence using urinary catechins, the primary flavonoids in tea. The primary outcomes will be compliance with tea intake and 2 MRI examinations. As secondary outcomes, we will measure standard and novel cardiovascular risk markers, including inflammatory, prothrombotic, fibrinolytic, and metabolic factors. We will also assess the effects of tea consumption on oxidizability of LDL and VLDL cholesterol, using a novel affinity-column chromatography approach, on oxidative damage to DNA, and on endothelial integrity, as assessed by serum markers of endothelial function. If successful, this pilot study will form the basis for a larger, long-term randomized trial to determine the effect of tea consumption on progression of atherosclerosis.

描述（由申请人提供）：人们普遍认为茶对健康有益，尤其是对心血管疾病（CVD）有益。 我们的研究小组最近发现，在 1900 名因心肌梗塞住院的患者中，每天喝 2 杯或更多茶的长期死亡率比不喝茶低 44%。 短期试验支持茶对内皮功能的益处，但需要进行茶摄入对心血管疾病和动脉粥样硬化的长期随机试验，以明确测试茶的影响。 我们提出了一项关于长期饮茶对动脉粥样硬化影响的原理验证试点研究。 我们将从大型医院的初级保健实践中招募并随机分配 30 名 CVD 高风险患者，为期六个月，每天饮用 3 杯茶，以易溶于热或冷的红茶固体形式提供液体或水。 我们将在基线时确认这些固体的多酚含量，并在整个研究过程中使用同一批茶。 在基线和 6 个月后，我们将使用磁共振成像评估主动脉粥样硬化，这是一种准确且可重复的测量动脉斑块大小的方法。 我们将使用尿儿茶素（茶中的主要黄酮类化合物）来测量依从性。 主要结果是茶摄入量和 2 次 MRI 检查的依从性。 作为次要结果，我们将测量标准和新型心血管风险标志物，包括炎症、血栓前、纤溶和代谢因素。 我们还将使用新型亲和柱色谱方法评估饮茶对 LDL 和 VLDL 胆固醇氧化性的影响、对 DNA 氧化损伤的影响，以及通过内皮功能血清标志物评估的内皮完整性的影响。 如果成功，这项试点研究将为更大规模的长期随机试验奠定基础，以确定饮茶对动脉粥样硬化进展的影响。

项目成果

Tea consumption and infarct-related ventricular arrhythmias: the determinants of myocardial infarction onset study.

饮茶和梗塞相关的室性心律失常：心肌梗塞发病的决定因素研究。

• DOI: 10.1080/07315724.2006.10719561
• 发表时间: 2006
• 期刊: Journal of the American College of Nutrition
• 影响因子: 3.5
• 作者: Mukamal,KennethJ;Alert,Marissa;Maclure,Malcolm;Muller,JamesE;Mittleman,MurrayA
• 通讯作者: Mittleman,MurrayA