Active Bottle for Home Care of Dysphagic Infants

用于吞咽困难婴儿家庭护理的主动奶瓶

• 批准号: 6932930
• 负责人: JAMES Hunter GOLDIE
• 金额: $ 14.16万
• 依托单位: INFOSCITEX CORPORATION
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-06-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6932930
• 关键词: biomedical equipment development; dysphagia; health care quality; home health care; infant human (0-1 year); nonbiomedical equipment; oral behavior; swallowing

DESCRIPTION (provided by applicant): An active infant feeding bottle is proposed for home care feeding of dysphagic infants to promote coordination of sucking, swallowing, and breathing during oral feeding. Neurogenic dysphagia among infants is characterized by difficulty with active transport of liquid to the mouth and stomach. During oral feeding, these infants are prone to aspirating fluid into the lungs, and are therefore at risk of pneumonia. Once discharged to home care, these children are likely to return frequently for outpatient treatment of their chronic feeding problems. Ultimately, the proposed active bottle will precisely dispense milk during bottle-feeding, based on measurements obtained from onboard sensors, encouraging the child to maintain an "optimum" feeding pattern. The intent of the bottle is to achieve more effective and better individualized home care treatment for each child and, hence, to reduce the dependence on hospital care. The incremental direct medical costs of low birth weight in the first year of life in the U.S. exceeded 4 billion dollars in 1988, accounting for 35% of total health care costs for infants. Furthermore, serious health consequences may result if these feeding problems persist once infants are discharged to home, including malnutrition and impaired intellectual growth. A reduction in number of hospital visits associated with oral feeding difficulty could substantially reduce health care costs and perhaps reduce the risk of later feeding-related health problems. The Phase I will necessarily focus on development and test of the home care active bottle, whereas in Phase II we will conduct human clinical trials to determine its safety and efficacy. The Phase I will consist of design and construction of an active bottle system prototype; bench testing in the laboratory of the prototype to confirm the necessary performance of each of the components of the system; and system testing in which representative sensor data (from past measurements on children) will be input to the control computer and the response of the system observed. We conclude with a planning task necessary to begin testing with infants during a Phase II.

描述（由申请人提供）： 提出了一个活跃的婴儿喂养瓶，用于对吞咽困难的婴儿进行家庭护理喂养，以促进口服喂养过程中吮吸，吞咽和呼吸的协调。 婴儿中的神经源性吞咽困难的特征是将液体在口腔和胃中主动运输困难。 在口服喂养过程中，这些婴儿容易吸入肺部，因此有肺炎的风险。 一旦出院到家护理，这些孩子可能会经常返回以治疗其慢性喂养问题。 最终，根据板载传感器获得的测量值，提议的活跃瓶将精确地分配牛奶，鼓励孩子保持“最佳”进食方式。 瓶子的目的是为每个孩子获得更有效，更具个性化的家庭护理治疗，并因此减少对医院护理的依赖。 1988年，美国第一年的低出生体重的直接医疗费用超过40亿美元，占婴儿总医疗保健成本的35％。 此外，如果婴儿出院到家，包括营养不良和智力增长受损，可能会导致严重的健康后果。 与口服喂养难度相关的医院探访数量减少可能会大大降低医疗费用，并可能降低以后与喂养有关的健康问题的风险。 第一阶段必须集中于家庭护理活动瓶的开发和测试，而在第二阶段，我们将进行人类的临床试验以确定其安全性和功效。 I阶段将包括设计和构建活动瓶系统原型；原型实验室中的台式测试，以确认系统的每个组件的必要性能；和系统测试，其中代表性的传感器数据（来自儿童的过去测量值）将输入控制计算机以及观察到的系统响应。 我们以在II阶段开始对婴儿进行测试所需的计划任务结束。