Predictors of Adverse metabolic effects of sleep loss

睡眠不足对代谢产生不利影响的预测因素

• 批准号: 6941374
• 负责人: Karine Spiegel
• 金额: $ 29.7万
• 依托单位: FREE UNIVERSITY OF BRUSSELS-JETTE CAMPUS
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6941374
• 关键词: autonomic nervous system; biomarker; body composition; clinical research; human middle age (35-64); human subject; leptin; metabolic syndrome; obesity; prognosis; sleep apnea; sleep deprivation; weight gain

DESCRIPTION (provided by applicant): Chronic sleep loss, obesity and sleep-disordered breathing (SDB) are increasingly common in industrialized countries. Sleep curtailment in healthy young lean adults results in the development of components of the metabolic syndrome, including reduced glucose tolerance and/or insulin resistance, elevated evening cortisol levels, increased cardiac sympatho-vagal balance, and a risk of weight gain resulting from reduced leptin levels and increased hunger and appetite. The studies proposed in the present application build on novel findings from our group that indicate that obese individuals may be more at risk for further weight gain than lean individuals in conditions of sleep loss, and that individuals levels of slow wave activity (SWA), a stable trait-dependent marker of deep sleep, may predict subjective vulnerability to sleep loss, and are also likely to predict the severity of adverse metabolic and cardiovascular consequences of sleep loss. We therefore propose to characterize sleep architecture, autonomic nervous system (ANS) activity, and biomarkers of the metabolic syndrome in three groups of middle aged (35-50 years old) subjects studied while they follow their usual sleep habits as well as during 4 days of sleep restriction and sleep extension, presented in randomized order in a cross-over design. The three groups of subjects will be healthy lean men and women, gender-matched individuals who are obese, and gender-matched individuals who are obese and also suffer from SDB. The specific aims are: 1. To test the hypothesis that baseline levels of SWA are lower in obese adults than in lean controls, and are even lower in obese subjects with SDB, and examine correlations between levels of SWA and sleep duration, ANS activity and biomarkers of the metabolic syndrome. 2. To test the hypothesis that sleep restriction, as compared to sleep extension, has adverse effects on biomarkers of the metabolic syndrome in lean adults, obese adults, and obese adults with SDB. 3. To test the hypothesis that the adverse impact of partial sleep loss on components of the metabolic syndrome is more important for obese adults than in lean adults, and more severe in obese adults with SDB than in those without SDB. This project capitalizes on our experience with human studies of "sleep debt" and on our extensive expertise in assessment of ANS activity to evaluate the role of the ANS as a mediator of the adverse health effects of chronic sleep loss.

描述（由申请人提供）： 在工业化国家，慢性睡眠丧失，肥胖和呼吸呼吸（SDB）越来越普遍。健康的年轻瘦成年人的睡眠减少会导致代谢综合征成分的发展，包括降低葡萄糖耐受性和/或胰岛素抵抗，晚上皮质醇水平升高，心脏交感神经差平衡的增加，以及瘦素水平降低以及饥饿和食欲增加而导致体重增加的风险。本申请中提出的研究是基于我们小组的新发现，表明肥胖个体可能比在睡眠不足条件下要比精益个体更容易受到进一步的体重增加的风险，并且在慢波活动的个人水平（SWA）水平（SWA）水平，这是一个稳定的深度睡眠特质依赖性标记，可能会预测睡眠损失的主观脆弱性，并且也可能预测不良的疾病的严重性造成不良的疾病的影响。因此，我们建议表征睡眠结构，自主神经系统（ANS）活性以及代谢综合征的生物标志物在三组中年龄（35-50岁）的受试者中，他们遵循他们通常的睡眠习惯以及在4天的睡眠限制和睡眠扩展期间，他们在交叉设计中以随机的顺序呈现。这三组受试者将是健康的瘦男人和女人，肥胖的性别匹配的人，以及肥胖的性别匹配的人，也患有SDB。具体目的是：1。测试肥胖成年人的基线基线水平低于瘦肉对照的假设，而在患有SDB的肥胖受试者中，SWA和睡眠持续时间，ANS活性，ANS活性和代谢综合征的生物标志物之间的相关性甚至低。 2。检验以下假设：与睡眠扩展相比，睡眠限制对瘦成年人，肥胖成年人和患有SDB的肥胖成年人的代谢综合征的生物标志物具有不利影响。 3。检验以下假设：部分睡眠损失对代谢综合征组成部分的不利影响对肥胖成年人而言比在瘦成年人中更为重要，而对于SDB的肥胖成年人来说，对肥胖成年人的不利影响比没有SDB的成年人更为严重。该项目利用了我们对“睡眠债务”研究的经验以及我们在评估ANS活动方面的广泛专业知识，以评估ANS作为慢性睡眠损失不良健康影响的调解人的作用。