Metamemory Deficits in People with Alzheimer's Disease

阿尔茨海默病患者的元记忆缺陷

• 批准号: 6942237
• 负责人: AYANNA K Thomas
• 金额: $ 5.69万
• 依托单位: COLBY COLLEGE
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6942237
• 关键词: Alzheimer' s disease; awareness; behavior test; behavioral /social science research tag; clinical research; cues; functional ability; human subject; memory disorders; neuropsychology; psychometrics; self concept

DESCRIPTION (provided by applicant): This proposal is written in response to PAR 03-056 and focuses on research topic number 16 (Executive Function). Metamemory is traditionally defined as the knowledge and awareness we have about our own memory. Metamemory focuses on the interplay between monitoring our mental state and controlling our cognitive processes. Awareness of our memory capabilities allows us to implement strategies to better remember events. Metamemory failure in people with Alzheimer's disease (AD) can influence episodic memory through the failure to allocate resources during study or the failure to reject possible competitor items at test. To further investigate metamemory in people with AD, a judgment-of-learning (JOL) procedure is adopted in which participants are asked to judge how easy it will be to remember an item immediately after studying that item. Researchers have proposed that JOLs are influenced by three classes of cues: intrinsic, extrinsic, and mnemonic. Intrinsic factors include item properties; extrinsic factors pertain to the encoding operations applied by a learner; mnemonic factors include idiosyncratic knowledge about one's own memory. These factors will be examined in detail to determine what cues lead to the most accurate metamemory performance. Further, the proposed research examines whether the deficit in episodic memory JOLs is reliably related to impaired executive functions as assessed through psychometric measures that have been localized to frontal and medial temporal regions. Three experiments manipulate intrinsic, extrinsic, and mnemonic cues independently. Memory accuracy will be compared to JOLs using Goodman-Kruskal gamma (y) correlations and absolute calibration. Metamemory accuracy will be correlated to psychometric measures in order to assess the neurological underpinnings of metamemory deficits. Results from this research will foster the development of a larger federal grant proposal which will investigate how reliance on metamemory can be used to improve episodic memory in people with AD.

描述（由申请人提供）：该提案是根据PAR 03-056编写的，并重点介绍了研究主题编号16（执行功能）。传统上，Metamemory被定义为我们对自己的记忆的知识和意识。 Metamemory着重于监测我们的精神状态与控制我们的认知过程之间的相互作用。对我们的内存功能的认识使我们能够实施策略以更好地记住事件。阿尔茨海默氏病（AD）患者的元记忆失败会通过研究期间未能分配资源或未能拒绝测试中可能的竞争者项目而影响情节记忆。为了进一步调查AD患者的元教育，采用了学习判决（JOL）程序，其中要求参与者判断研究该项目后立即记住项目的容易。研究人员提出，JOL受三类线索的影响：内在，外在和助记符。内在因素包括项目属性；外部因素与学习者应用的编码操作有关；疯子因素包括有关自己的记忆的特质知识。这些因素将进行详细检查，以确定哪些提示导致最准确的元素性能。此外，拟议的研究研究了情节记忆JOL中的赤字是否与通过本地定位于额叶和内侧时间区域的心理测量指标评估的行政功能可靠地相关。三个实验可独立操纵固有，外部和助记符线索。使用Goodman-Kruskal Gamma（Y）相关性和绝对校准将与JOL进行比较。元素准确性将与心理测量措施相关，以评估元症状缺陷的神经系统基础。这项研究的结果将促进一项更大的联邦赠款提案的发展，该提案将调查如何使用对元符号的依赖来改善AD患者的情节记忆。