CLINICAL CORE

临床核心

• 批准号: 6989328
• 负责人: JOHN MORRIS
• 金额: $ 11.13万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6989328
• 关键词: Alzheimer' s disease; apolipoprotein E; behavioral /social science research tag; biomarker; biomedical facility; clinical research; cognition; disease /disorder proneness /risk; genetic registry /resource /referral center; genotype; human genetic material tag; human middle age (35-64); human old age (65+); human subject; longitudinal human study; medical outreach /case finding; neuropathology; postmortem; psychometrics

The Core supports the Adult Children Study Program Project Grant (ACS PPG) by recruiting adult children of parents with and without dementia of the Alzheimer type (DAT) for comprehensive clinical and cognitive (psychometric) assessments at entry and every 3 years thereafter (annually for ACS participants >65y). The Core also supplies all Projects with participants. Core data are entered by Core personnel into the database maintained by the Data Management and Statistics (DMS) component of the Administration Core. The Clinical Core interacts directly or indirectly on a daily basis with virtually every facet of the ACS PPG. The Specific Aims of the Core are to: 1. Recruit, enroll, and maintain the ACS cohort to support the Projects in this application. In each of the first 3 years of the grant, the Core will enroll 80 ACS participants for a total sample of 240 participants. Participants will be recruited in 3 age groups in each of 2 categories: a. Category 1 (total sample = 120 participants): at least one biologic parent with DAT with age at onset (AAO) before 80y: 1) Age group 45-54y (n=40); 2) Age group 55-64y (n=40); 3) Age group 65-74y (n=40). b. Category 2 (total sample = 120 participants): neither biologic parent with DAT (both must be >70y): 1) Age group 45-54y (n=40); 2) Age group 55-64y (n=40); 3) Age group 65-74y (n=40). 2. Comprehensively assess the ACS participants with well-established clinical and cognitive measures every three years (annually for those >65y) and request voluntary permission for autopsy .3. Obtain blood for apolipoprotein E (apoE) genotyping and banking of extracted DNA and plasma (supported by the Genetics Core of the Alzheimer's Disease Research Center). 4. Coordinate the participation of ACS participants in all Projects: Project 1 - Amyloid imaging in the Adult Children Study; Project 2 - CSF markers of antecedent AD; Project 3 - Attentional profiles as an early marker of DAT; Project 4 - Neuroanatomical markers of early AD 5. Integrate all Core data with the DMS component of the Administration Core and interact cooperatively with all components of the PPG.

核心通过招募有或没有阿尔茨海默氏症痴呆症的父母的成年子女（DAT）来支持成人儿童研究计划赠款（ACS PPG），以进行全面的临床和认知（心理计量学）评估，此后每3年（每年每3年） ACS参与者> 65y）。核心还向参与者提供所有项目。核心人员由核心人员输入到由管理核心的数据管理和统计（DMS）组件维护的数据库中。临床核心每天直接或间接与ACS PPG的每个方面进行相互作用。核心的具体目的是：1。招募，注册和维护ACS队列以支持本应用程序中的项目。在赠款的前三年中，核心将招募80个ACS参与者，共有240名参与者。参与者将在2个类别中的每个年龄组中分为3个年龄组：类别1（总样本= 120名参与者）：至少一位生物父母在80年之前（AAO）年龄（aao）dat：1）年龄组45-54Y（n = 40）; 2）年龄组55-64Y（n = 40）; 3）年龄组65-74Y（n = 40）。 b。类别2（总样本= 120名参与者）：既不具有DAT的生物父母（两者都必须> 70y）：1）年龄组45-54Y（n = 40）; 2）年龄组55-64Y（n = 40）; 3）年龄组65-74Y（n = 40）。 2。全面评估ACS参与者，每三年（每年> 65岁> 65岁）采用公认的临床和认知措施来评估ACS参与者，并要求自愿许可进行尸检.3。获得载脂蛋白E（APOE）基因分型的血液和提取的DNA和等离子体（由阿尔茨海默氏病研究中心的遗传学核心支持）。 4。协调ACS参与者参与所有项目的参与：项目1-成年儿童研究中的淀粉样蛋白成像；项目2 -CSF标记AD；项目3-注意概况作为DAT的早期标记；项目4 -AD 5早期的神经解剖标记。将所有核心数据与管理核心的DMS组件整合在一起，并与PPG的所有组件合作进行交互。