Internalizing Symptoms and Alcohol Involvement

内化症状和酒精参与

• 批准号: 6969811
• 负责人: Rosa M. Crum
• 金额: $ 29.34万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-15 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6969811
• 关键词: alcoholism /alcohol abuse; anxiety; behavior prediction; behavioral /social science research tag; behavioral genetics; clinical research; comorbidity; gender difference; human data; longitudinal human study; major depression; meta analysis; racial /ethnic difference

DESCRIPTION (provided by applicant): The goal of this revised R01 application is to use existing prospectively gathered data to examine the pathways from initial alcohol use through transitional phases that lead to alcohol dependence. Although prior clinical and population-based studies have provided strong evidence for the comorbid relationship of internalizing symptoms such as anxiety and depression with alcohol use, there is still relatively little data that provide information on the relationships of anxiety and depressive symptoms in the potential etiologic pathways towards alcohol dependence. In this application, using prospectively gathered data from early childhood (grade 1) through young adulthood, and based on a conceptual framework that incorporates the life-course developmental model, 2 specific studies are proposed. The first study proposes 1) To assess the association of anxiety and depressive symptoms with risk for onset of varying stages of alcohol involvement: a) the report of opportunities to use alcohol, b) initiation and use of alcohol, c) occurrence of alcohol-related problems, and d) development of alcohol abuse and/or dependence. These analyses would be completed separately by developmental stage (e.g., childhood, adolescence, and young adulthood). In addition, we propose to assess whether the relationships of internalizing symptoms with alcohol involvement differ by race, and gender. The second study proposes to examine trajectories of comorbid internalizing symptoms with alcohol involvement using latent class analysis. We propose: 1) To empirically define the underlying structure of alcohol involvement at each developmental stage and examine its relationship to anxiety and depressive symptoms; 2) To examine the effects of internalizing symptoms on the progression across stages of alcohol involvement using latent transition analysis; and 3) To characterize patterns of growth in drinking behavior and their relationship to internalizing symptoms. This proposal aims to address some of the gaps in our knowledge of relationships between anxiety and depressive symptoms with alcohol involvement. Findings from these analyses would have potentially significant application to the elucidation of antecedents for alcohol use involvement and for identifying potentially malleable targets for preventive and intervention programs, which ultimately may reduce the incidence and prevalence of alcohol-related problems and alcohol use disorders.

描述（由申请人提供）：此修订版 R01 申请的目标是使用现有的前瞻性收集的数据来检查从最初饮酒到导致酒精依赖的过渡阶段的途径。尽管先前的临床和基于人群的研究已经为焦虑和抑郁等内化症状与饮酒之间的共病关系提供了强有力的证据，但仍然有相对较少的数据提供有关焦虑和抑郁症状在潜在病因途径中的关系的信息。走向酒精依赖。在本申请中，使用从幼儿期（一年级）到青年期前瞻性收集的数据，并基于纳入生命历程发展模型的概念框架，提出了两项​​具体研究。第一项研究提出 1) 评估焦虑和抑郁症状与不同阶段的酒精参与风险之间的关系：a) 饮酒机会的报告，b) 开始和使用酒精，c) 酒精的发生相关问题，以及 d) 酗酒和/或依赖的发展。这些分析将按发育阶段（例如儿童期、青春期和青年期）单独完成。此外，我们建议评估内化症状与酒精参与的关系是否因种族和性别而异。第二项研究建议使用潜在类别分析来检查与酒精相关的共病内化症状的轨迹。我们建议：1）根据经验定义每个发育阶段酒精参与的基本结构，并检查其与焦虑和抑郁症状的关系； 2) 使用潜在转变分析检查内化症状对酒精参与各阶段进展的影响； 3) 描述饮酒行为的增长模式及其与内化症状的关系。该提案旨在弥补我们对酒精参与的焦虑和抑郁症状之间关系的认识上的一些空白。这些分析的结果可能对阐明酒精使用的前因以及确定预防和干预计划的潜在可塑目标具有潜在的重要应用，这最终可能会减少酒精相关问题和酒精使用障碍的发生率和患病率。