Quantitative Electrical Measure of Brain Injury

脑损伤的定量电测量

基本信息

批准号：
7108907
负责人：
NITISH VYOMESH THAKOR
金额：
$ 3.26万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-09-18 至 2005-08-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): In the basic and clinical research on brain's response to injury, cortical electrical signals from the brain, namely EEG, may be useful in providing an immediate indication of the dysfunction. As such, we hypothesize that quantitative EEG would be a powerful tool for basic research on brain injury and, eventually, clinical diagnosis. A novel approach to analyzing brain's early response to injury, based on the method of "multiresolution wavelet entropy (MRWE)" is proposed. Since the recovery of brain rhythms in response to injury occurs in different stages involving transition of rhythmic activities in different frequency bands, we propose to monitor and quantify the variations in entropy that occur within each clinical band. We hypothesize that a) following global ischemic brain injury, the time domain entropy of EEG would form a sensitive indicator of the level of injury and that the MRWE of EEG in each clinical band would identify features related to the bursting characteristics of EEG in the immediate post-ischemic recovery periods, and b) the corresponding entropy measure derived from the cortical field potentials would have cellular origins (firing pattern of neurons) in cortical and subcortical areas of the brain. To explore these hypotheses and to develop rigorous theoretical tools for experimental studies on brain injury, we propose: 1: Theory - a) Derive a time domain entropy measure with a view to monitor the progress of recovery of EEG following global ischemic brain injury. b) Derive an MRWE-based segmentation procedure to identify the characteristics of initial bursting EEG, seen during early phases of post-ischemic recovery. 2: Experiments - Using experimental single and multi-unit recording by the microelectrode method, show that the varying levels of MRWE derived from the cortical field potentials reflect the transitional stages of post-ischemic rhythmic activity of neuronal population in the thalamus and the cortex. The significance of this project primarily lies in developing a novel quantitative tool that can benefit basic and clinical scientists studying brain injury.

描述（由申请人提供）：在大脑对损伤反应的基础和临床研究中，来自大脑的皮质电信号，即脑电图，可能有助于立即指示功能障碍。因此，我们假设定量脑电图将成为脑损伤基础研究以及最终临床诊断的强大工具。提出了一种基于“多分辨率小波熵（MRWE）”方法来分析大脑对损伤的早期反应的新方法。由于响应损伤的大脑节律的恢复发生在不同阶段，涉及不同频带中节律活动的转变，因此我们建议监测和量化每个临床频带内发生的熵的变化。我们假设a）在整体缺血性脑损伤后，脑电图的时域熵将形成损伤水平的敏感指标，并且每个临床频带中脑电图的MRWE将识别与脑电图的突发特征相关的特征。缺血后恢复期，b）从皮质场电位导出的相应熵测量将在大脑的皮质和皮质下区域具有细胞起源（神经元的放电模式）。为了探索这些假设并为脑损伤的实验研究开发严格的理论工具，我们建议： 1：理论 - a）推导时域熵测量，以监测全球缺血性脑损伤后脑电图的恢复进度。 b) 推导基于 MRWE 的分割程序，以识别在缺血后恢复的早期阶段看到的初始突发脑电图的特征。图2：实验-使用微电极方法进行实验性单单元和多单元记录，表明来自皮质场电位的MRWE的不同水平反映了丘脑和皮质神经元群体缺血后节律活动的过渡阶段。该项目的意义主要在于开发一种新颖的定量工具，可以使研究脑损伤的基础和临床科学家受益。