Quantitative Electrical Measure of Brain Injury

脑损伤的定量电测量

基本信息

批准号：
7108907
负责人：
NITISH VYOMESH THAKOR
金额：
$ 3.26万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-09-18 至 2005-08-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): In the basic and clinical research on brain's response to injury, cortical electrical signals from the brain, namely EEG, may be useful in providing an immediate indication of the dysfunction. As such, we hypothesize that quantitative EEG would be a powerful tool for basic research on brain injury and, eventually, clinical diagnosis. A novel approach to analyzing brain's early response to injury, based on the method of "multiresolution wavelet entropy (MRWE)" is proposed. Since the recovery of brain rhythms in response to injury occurs in different stages involving transition of rhythmic activities in different frequency bands, we propose to monitor and quantify the variations in entropy that occur within each clinical band. We hypothesize that a) following global ischemic brain injury, the time domain entropy of EEG would form a sensitive indicator of the level of injury and that the MRWE of EEG in each clinical band would identify features related to the bursting characteristics of EEG in the immediate post-ischemic recovery periods, and b) the corresponding entropy measure derived from the cortical field potentials would have cellular origins (firing pattern of neurons) in cortical and subcortical areas of the brain. To explore these hypotheses and to develop rigorous theoretical tools for experimental studies on brain injury, we propose: 1: Theory - a) Derive a time domain entropy measure with a view to monitor the progress of recovery of EEG following global ischemic brain injury. b) Derive an MRWE-based segmentation procedure to identify the characteristics of initial bursting EEG, seen during early phases of post-ischemic recovery. 2: Experiments - Using experimental single and multi-unit recording by the microelectrode method, show that the varying levels of MRWE derived from the cortical field potentials reflect the transitional stages of post-ischemic rhythmic activity of neuronal population in the thalamus and the cortex. The significance of this project primarily lies in developing a novel quantitative tool that can benefit basic and clinical scientists studying brain injury.

描述（由申请人提供）：在有关大脑对损伤反应的基础和临床研究中，来自大脑的皮质电信号，即脑电图，可能对提供功能障碍的立即指示很有用。因此，我们假设定量性脑电图将是有关脑损伤基础研究以及最终临床诊断的强大工具。提出了一种基于“多解决小波熵（MRWE）”的方法来分析大脑对损伤的早期反应的新方法。由于响应损伤的脑节律的恢复发生在不同频段中节奏活动过渡的不同阶段，因此我们建议监测和量化每个临床带中发生的熵变化。我们假设a）a）a）在全球缺血性脑损伤之后，脑电图的时间域熵将形成损伤水平的敏感指标，并且每个临床频带中的EEG的MRWE将确定与脑电图爆发特征相关的特征大脑皮层下区域。为了探索这些假设并为有关脑损伤的实验研究开发严格的理论工具，我们提出：1：理论 - a）得出时间域熵措施，以监测全球缺血性脑损伤后脑电图的恢复进度。 b）得出一种基于MRWE的分割程序，以识别在缺血后恢复的早期阶段中可见的初始爆发脑电图的特征。 2：实验 - 使用微电极方法使用实验单单和多单元记录，表明从皮质场电位衍生的MRWE水平的不同水平反映了丘脑和皮质中神经元种群中缺血后节律活性的过渡阶段。该项目的重要性主要在于开发一种新型的定量工具，该工具可以使研究脑损伤的基本和临床科学家受益。