AGRICULTURAL DUST AND CHILDHOOD ASTHMA SYMPTOMS

农业灰尘和儿童哮喘症状

• 批准号: 6602028
• 负责人: Steven B Wing
• 金额: $ 10.74万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-01 至 2005-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6602028
• 关键词: adolescence (12-20); agriculture; air pollution; airborne allergen; asthma; clinical research; environmental exposure; human subject; pollution related respiratory disorder; respiratory disorder epidemiology

DESCRIPTION (provided by applicant): The proposed study will assess the relationship between exposure to industrial livestock operations and the prevalence of asthma-related symptoms among 7TH and 8TH grade students attending public schools in North Carolina. During the 1999-2000 school year, the North Carolina Department of Health and Human Services conducted a statewide population-based survey of middle school students in order to assess the prevalence of asthma-related symptoms, medication use, barriers to adequate medication use, and behavioral consequences of the reported symptoms. This application seeks to extend the benefit and utility of the statewide survey by exploring the relationship between the prevalence of asthma symptoms among surveyed students and exposure to agricultural airborne pollutants experienced during school hours. School-based exposure will be estimated using an extensive database of industrial livestock operations, including information about the size, type of animals, geographic location, and waste management practices. Exposure estimates will be supplemented with information provided about the school environment, including air-conditioning, mold, odor, and other school-building characteristics. Epidemiologic analyses will focus on the association between the prevalence of asthma-related symptoms and exposure estimates. The specific aims of this study are: (1) to estimate exposure to airborne emissions from industrial livestock operations at public middle schools using spatial analysis of the following measurements: (a) distance from the livestock operation to the middle school, (b) steady state live weight of all animals in livestock operations surrounding a given middle school, and (c) information obtained from school personnel about odor, environmental, and physical conditions at the schools; (2) to determine whether students' risk of asthma-related symptoms is related to the distance to the nearest industrial livestock operation, quantity of animals near the school, and school-based exposure to industrial livestock; and (3) to evaluate the distribution of asthma-related symptoms and exposures within geographic, racial, and socio-economic categories to determine whether the frequency and severity of symptoms and livestock exposures most heavily burden specific subpopulations of students.

描述（由申请人提供）：拟议的研究将评估北卡罗来纳州公立学校七年级和八年级学生接触工业化畜牧业与哮喘相关症状患病率之间的关系。 1999-2000 学年，北卡罗来纳州卫生与公众服务部对全州中学生进行了一项以人口为基础的调查，以评估哮喘相关症状、药物使用、充分药物使用的障碍以及哮喘相关症状的患病率。所报告症状的行为后果。该应用程序旨在通过探索接受调查的学生中哮喘症状的患病率与在校期间接触农业空气污染物之间的关系来扩大全州范围内调查的益处和效用。将使用工业畜牧业运营的广泛数据库来估计学校的接触量，包括有关动物大小、类型、地理位置和废物管理实践的信息。暴露估计将得到有关学校环境的信息的补充，包括空调、霉菌、气味和其他学校建筑特征。流行病学分析将重点关注哮喘相关症状的患病率与暴露估计之间的关联。本研究的具体目的是：(1) 使用以下测量值的空间分析来估计公立中学工业畜牧业的空气排放暴露：(a) 畜牧业到中学的距离，(b) 稳定说明某所中学周围畜牧业中所有动物的活重，以及 (c) 从学校工作人员处获得的有关学校气味、环境和物质条件的信息； (2) 确定学生出现哮喘相关症状的风险是否与距最近的工业牲畜养殖场的距离、学校附近的动物数量以及在学校接触工业牲畜的情况有关； (3) 评估哮喘相关症状和暴露在地理、种族和社会经济类别中的分布，以确定症状的频率和严重程度以及牲畜暴露是否对特定学生亚群造成最严重的负担。