NATIONAL RESOURCE CENTER FOR CEPHALOPODS

国家头足类资源中心

• 批准号: 7153972
• 负责人: PHILLIP Grant LEE
• 金额: $ 20.07万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-03-01 至 2006-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7153972
• 关键词: Cephalopoda; Internet; alternatives to animals in research; animal care; animal colony; aquaculture; information dissemination; marine biology; model design /development; squid; tissue /cell culture; tissue resource /registry

The role of cephalopods as invertebrate models for biomedical research cannot be overvalued from the Nobel prizes awarded in the last century to the rapid increase in publications using cephalopods in this century-an exponential increase in the last decade. Concurrent with this dramatic increase in cephalopod biomedical research, the NRCC has expanded the numbers of cephalopod species and individual cephalopods it produces. Furthermore, the NRCC has become more cost efficient and diversified its funding by obtaining a majority of its budget from user fees as well as state matching funds. The NRCC's primary mission addresses NCRR's strategic plan: (1) to provide institutional support for the development and maintenance of research models and (2) disseminate information on available models, as well as its mission, "to serve as a catalyst for discovery." The NRCC was one of the first of the alternative invertebrate model centers funded by NCRR and we continue to meet the expanding needs of biomedical scientists now (serving >40% of current grants using cephalopods) and in the future (supplying cephalopods for pilot projects) as these investigators move forward in unraveling the developmental processes and biological functions of living organisms in relation to human health. The specific aims of the proposal are (1) To continue to operate the NRCC economically by culturing key species and maintaining other species as needed, expanding the user base through cost-effective electronic advertising, and monitoring the long-term health of these populations; (2) To become the primary source of both specimens and information on the biomedical uses of cephalopods by developing our NRCC web site (www.nrcc.utmb.edu<http://www.nrcc.utmb.edu>), interacting with other cephalopod internet sites (i.e., CephBase and Cephalopod Page), and operating a List Server for cephalopods, FastMoll; and (3) To continue to expand the number of cephalopod species available for use in biomedicine by culturing two new squid species, Sepioteuthis australis, and Euprymna tasmanica.

从上个世纪颁发的诺贝尔奖到本世纪使用头足类动物的出版物的迅速增加（在过去十年中呈指数级增长），头足类动物作为生物医学研究无脊椎动物模型的作用怎么强调都不为过。在头足类生物医学研究急剧增加的同时，NRCC 扩大了头足类物种及其生产的个体头足类动物的数量。此外，NRCC 的大部分预算来自使用费和国家配套资金，从而提高了成本效率并实现了资金多元化。 NRCC 的主要使命涉及 NCRR 的战略计划：(1) 为研究模型的开发和维护提供机构支持，(2) 传播有关可用模型的信息，以及其使命“充当发现的催化剂”。 NRCC 是 NCRR 资助的首批替代无脊椎动物模型中心之一，我们继续满足生物医学科学家现在（使用头足类动物提供当前拨款的 40% 以上）和未来（为试点项目提供头足类动物）不断增长的需求随着这些研究人员在阐明与人类健康相关的生物体的发育过程和生物功能方面取得进展。该提案的具体目标是 (1) 通过培育关键物种并根据需要维护其他物种，继续以经济方式运营 NRCC，通过具有成本效益的电子广告扩大用户群，并监测这些种群的长期健康状况； (2) 通过开发我们的 NRCC 网站 (www.nrcc.utmb.edu<http://www.nrcc.utmb.edu>)，成为头足类动物生物医学用途标本和信息的主要来源，与其他头足类网站（即 CephBase 和 Cephalopod Page），并运营头足类列表服务器 FastMoll； (3) 通过培育两个新鱿鱼品种——Sepioteuthis australis 和 Euprymna tasmanica，继续扩大可用于生物医学的头足类物种数量。