Growth Hormone Secretory Dynamics in Peripubertal Girls

青春期女孩的生长激素分泌动态

• 批准号: 6549837
• 负责人: STEVEN M PINCUS
• 金额: $ 9.71万
• 依托单位: STEVEN M PINCUS
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-07 至 2003-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6549837
• 关键词: Turner's syndrome; adolescence (12-20); body composition; clinical research; female; gender difference; hormone metabolism; hormone regulation /control mechanism; hormone therapy; human data; human puberty; longitudinal human study; male; secretion; somatotropin; statistics /biometry; thermodynamics

DESCRIPTION (provided by applicant): The primary objective is to determine the relationship between clinical growth in pubertal girls and boys and shifts in the irregularity of underlying growth hormone (GH) secretory patterns. Novel clarifications of this time-evolution could be significant in determining the proper timing of hormone replacement therapies in pathophysiological settings such as Turner's Syndrome or constitutional delay of growth and adolescence, and in enhancing physiologic understanding. We will also investigate gender differences in the growth-secretory pattern relationship. (Secretory) irregularity will be quantified by approximate entropy (ApEn), developed by the principal investigator. ApEn has been widely applied scientifically, with numerous applications to hormonal data providing complementarity to pulse detection methods. In two (cross-sectional; longitudinal) recent 6 year peripubertal studies of boys, we observed a highly significant correlation between increased OH secretory irregularity and subsequent growth velocity increase 4-8 months later, providing predictive capability. Phase I focuses on thematically similar data analysis from an improved longitudinal design, including girls and boys, additional (body composition) measurements, and sharper assays. Phase II will incorporate sex-steroid hormone and anthropometric data into regression models to obtain parsimonious factors most predictive of ensuing growth, applying this design to the aforementioned pathophysiologies, and to healthy children. PROPOSED COMMERCIAL APPLICATIONS: Software development of an ApEn program for application to general endocrine hormone secretion time series; incorporation of ApEn software into existing hormonal administration systems. In particular, collaborations with pharmaceutical companies who manufacture growth hormone.

描述（由申请人提供）：主要目标是确定青春期女孩和男孩的临床生长与潜在生长激素（GH）分泌模式不规则变化之间的关系。对这一时间演化的新的澄清可能对于确定特纳综合症或体质性生长和青春期延迟等病理生理环境中激素替代疗法的适当时机以及增强生理学理解具有重要意义。我们还将研究生长-分泌模式关系中的性别差异。 （秘书）不规则性将通过首席研究员开发的近似熵（ApEn）进行量化。 ApEn 已在科学上得到广泛应用，激素数据的大量应用为脉搏检测方法提供了补充。 在最近两项针对男孩的 6 年围青春期研究（横断面；纵向）中，我们观察到 OH 分泌不规则性增加与 4-8 个月后生长速度增加之间存在高度显着的相关性，从而提供了预测能力。第一阶段侧重于通过改进的纵向设计进行主题相似的数据分析，包括女孩和男孩、额外的（身体成分）测量和更清晰的分析。第二阶段将把性类固醇激素和人体测量数据纳入回归模型，以获得最能预测随后生长的简约因素，并将这种设计应用于上述病理生理学以及健康儿童。 拟议的商业应用： 应用于一般内分泌激素分泌时间序列的 ApEn 程序的软件开发；将 ApEn 软件纳入现有的激素管理系统。特别是与生产生长激素的制药公司的合作。