Walking Activity and the Burden of Multiple Morbidities

步行活动和多种疾病的负担

• 批准号: 7008650
• 负责人: JAMES TERRENCE CAVANAUGH
• 金额: $ 10.5万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-30 至 2006-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7008650
• 关键词: accidental falls; atmosphere /weather; behavioral /social science research tag; body composition; body physical activity; chordate locomotion; clinical research; comorbidity; data collection methodology /evaluation; functional ability; gait; human morbidity; human old age (65+); human subject; longitudinal human study; questionnaires; rehabilitation; self care

DESCRIPTION (provided by applicant): Traditional measurement approaches do not adequately capture the functional burden of coexisting diseases in older adults. To address this concern, we propose to develop and validate a novel approach based on the idea that functional burden can be characterized by patterns of walking activity measured over an extended period of time. One hundred older men and women representing a range of multiple medical conditions will be recruited to participate in a cross-sectional investigation. Walking activity will be recorded continuously over a two-week period using a highly accurate, step counting accelerometer. Activity will be characterized in terms of intensity (number of steps), frequency (number of activity-inactivity cycles), and duration (time spent walking at low, moderate, or high intensity.) Minute-to-minute fluctuations in the intensity of walking activity will be quantified in terms of variability (magnitude) and complexity (extent of randomness.) A variety of data reduction strategies will be explored. Secondary measures of function, disability, and self-efficacy will be collected to determine the validity of activity indices for capturing functional burden. The stability of activity indices will be determined over days and weeks. We hypothesize that greater numbers of morbidities will be associated not only with taking fewer steps, walking less often, and walking for shorter periods of time, but also with fluctuations in activity intensity that are less variable and complex. We believe that our extended monitoring approach will produce a physiologically-based characterization of functional burden that offers unique insight into the dynamics of interacting morbidities. The approach may contribute to the development of medical, surgical, or rehabilitative strategies for improving the ability of elderly patients to adapt to the physical demands of daily life. Study findings are likely to be relevant to aging studies arising from a variety of basic and clinical science disciplines.

描述（由申请人提供）：传统的测量方法不能充分捕捉老年人共存疾病的功能负担。为了解决这个问题，我们建议开发和验证一种新方法，该方法基于这样的想法：功能负担可以通过长时间测量的步行活动模式来表征。将招募代表多种健康状况的一百名老年男性和女性参与横断面调查。将使用高精度计步加速计在两周内连续记录步行活动。活动的特点是强度（步数）、频率（活动-不活动周期数）和持续时间（低、中或高强度行走的时间）。运动强度的每分钟波动步行活动将根据变异性（幅度）和复杂性（随机程度）进行量化。将探索各种数据缩减策略。将收集功能、残疾和自我效能的次要测量值，以确定捕获功能负担的活动指数的有效性。活动指数的稳定性将在几天和几周内确定。我们假设，更多的发病率不仅与较少的步数、较少的步行次数和较短的步行时间有关，而且还与变化较小且复杂的活动强度波动有关。我们相信，我们的扩展监测方法将产生基于生理学的功能负担特征，为相互作用的发病率的动态提供独特的见解。该方法可能有助于制定医疗、外科或康复策略，以提高老年患者适应日常生活身体需求的能力。研究结果可能与各种基础和临床科学学科的衰老研究相关。