2nd ASM Conference on Cell-Cell Communication

第二届 ASM 细胞间通信会议

• 批准号: 6836924
• 负责人: BONNIE L BASSLER
• 金额: $ 1.8万
• 依托单位: AMERICAN SOCIETY FOR MICROBIOLOGY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-10 至 2005-07-09
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6836924
• 关键词: bacteria; bacterial genetics; biofilm; biological signal transduction; cell cell interaction; gene expression; genetic regulation; meeting /conference /symposium; microorganism growth; quorum sensing; travel

DESCRIPTION (provided by applicant): Only a few years ago, the exchange of chemical signals, or pheromones, between bacteria was considered the exception rather than the rule. A small number of examples of cell-cell signaling had been well described, including the bioluminescence regulatory systems of Vibrio fischeri and Vibrio harveyi, the conjugal transfer system of Enterococcus faecatis, the production of antibiotics by Streptomyces spp., and the development of multicellular fruiting bodies of Myxococcus xanthus. It was assumed that cell-cell communication was not used by most bacteria. Cell-cell signaling in bacteria was considered at that time to be an interesting subject of research, but not one of fundamental importance to human health. In the past ten years, an enormous number of new examples of inter-bacterial signaling have been reported. These systems regulate a number of processes as diverse as virulence, sporulation, antibiotic production, DNA exchange, and development of multicellular structures. It is now understood that, in fact, most bacteria communicate with one another using secreted chemical molecules. Inter-cellular communication systems are fascinating because they allow bacteria to coordinately control the gene expression of the entire community. This ability fundamentally blurs the distinction between unicellular and multicellular forms of life. Several of these signaling systems are also extremely important to human health, because they regulate the virulence determinants of bacterial pathogens. Because of the recent explosion in research in the area of cell-cell communication in bacteria and its newly discovered role in eliciting human disease, the ASM hosted a conference devoted to cell-cell signaling during the summer of 2001. This meeting was so well received by its participants that the ASM became committed to provide an ongoing venue for this topic, and will host a second conference in July of 2004. The conference will be held at Banff, Alberta, in the Canadian Rockies. The NIH generously supported the first ASM sponsored meeting on this topic, and has supported many of the investigators that study cell-cell communication in bacteria, and it is hoped that the NIH will provide financial assistance for this upcoming conference.

描述（由申请人提供）：仅几年前，细菌之间的化学信号或信息素的交换被认为是例外而不是规则。已经很好地描述了细胞细胞信号传导的少数示例，包括纤维纤维Fischeri的生物发光调节系统和纤维虫Harveyi，粪肠球菌的结合转移系统，由链霉菌属的生产抗生素的生产。假定大多数细菌未使用细胞 - 细胞通信。当时认为细菌中的细胞细胞信号传导是一个有趣的研究主题，但对人类健康的重要性不是一个重要的重要性。在过去的十年中，已经报道了大量新的细菌信号传导示例。这些系统调节许多过程，例如毒力，孢子形成，抗生素产生，DNA交换和多细胞结构的开发。现在可以理解，实际上，大多数细菌使用分泌的化学分子相互沟通。细胞间通信系统令人着迷，因为它们允许细菌协调控制整个社区的基因表达。这种能力从根本上模糊了单细胞和多细胞形式之间的区别。这些信号系统中的几个对人类健康也非常重要，因为它们调节细菌病原体的毒力决定因素。由于最近在细菌沟通及其新发现在引发人类疾病中的作用的细胞细胞通信领域的研究中发生了爆炸，因此，ASM在2001年夏季举办了一次致力于细胞电池信号的会议。该会议受到其参与者的好评，以至于ASM致力于为此主题举行一场持续的会议，并将在7月举行一次会议，将在2004年举行一次会议。落基山脉。 NIH慷慨地支持有关该主题的第一次ASM赞助会议，并支持许多研究细菌细胞沟通的调查人员，希望NIH将为即将举行的会议提供经济援助。