2nd ASM Conference on Cell-Cell Communication

第二届 ASM 细胞间通信会议

• 批准号: 6836924
• 负责人: BONNIE L BASSLER
• 金额: $ 1.8万
• 依托单位: AMERICAN SOCIETY FOR MICROBIOLOGY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-10 至 2005-07-09
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6836924
• 关键词: bacteria; bacterial genetics; biofilm; biological signal transduction; cell cell interaction; gene expression; genetic regulation; meeting /conference /symposium; microorganism growth; quorum sensing; travel

DESCRIPTION (provided by applicant): Only a few years ago, the exchange of chemical signals, or pheromones, between bacteria was considered the exception rather than the rule. A small number of examples of cell-cell signaling had been well described, including the bioluminescence regulatory systems of Vibrio fischeri and Vibrio harveyi, the conjugal transfer system of Enterococcus faecatis, the production of antibiotics by Streptomyces spp., and the development of multicellular fruiting bodies of Myxococcus xanthus. It was assumed that cell-cell communication was not used by most bacteria. Cell-cell signaling in bacteria was considered at that time to be an interesting subject of research, but not one of fundamental importance to human health. In the past ten years, an enormous number of new examples of inter-bacterial signaling have been reported. These systems regulate a number of processes as diverse as virulence, sporulation, antibiotic production, DNA exchange, and development of multicellular structures. It is now understood that, in fact, most bacteria communicate with one another using secreted chemical molecules. Inter-cellular communication systems are fascinating because they allow bacteria to coordinately control the gene expression of the entire community. This ability fundamentally blurs the distinction between unicellular and multicellular forms of life. Several of these signaling systems are also extremely important to human health, because they regulate the virulence determinants of bacterial pathogens. Because of the recent explosion in research in the area of cell-cell communication in bacteria and its newly discovered role in eliciting human disease, the ASM hosted a conference devoted to cell-cell signaling during the summer of 2001. This meeting was so well received by its participants that the ASM became committed to provide an ongoing venue for this topic, and will host a second conference in July of 2004. The conference will be held at Banff, Alberta, in the Canadian Rockies. The NIH generously supported the first ASM sponsored meeting on this topic, and has supported many of the investigators that study cell-cell communication in bacteria, and it is hoped that the NIH will provide financial assistance for this upcoming conference.

描述（由申请人提供）：仅在几年前，细菌之间化学信号或信息素的交换还被认为是例外而不是规则。细胞间信号传导的少数例子已经得到很好的描述，包括费氏弧菌和哈维氏弧菌的生物发光调节系统、粪肠球菌的接合转移系统、链霉菌属抗生素的生产以及多细胞子实体的发育黄粘球菌的尸体。假设大多数细菌不使用细胞间通讯。当时，细菌中的细胞间信号传导被认为是一个有趣的研究课题，但对人类健康来说并不是一个根本重要的课题。在过去的十年中，已经报道了大量细菌间信号传导的新例子。这些系统调节许多不同的过程，如毒力、孢子形成、抗生素产生、DNA 交换和多细胞结构的发育。现在人们了解到，事实上，大多数细菌都是通过分泌的化学分子来相互交流的。细胞间通讯系统令人着迷，因为它们允许细菌协调控制整个群落的基因表达。这种能力从根本上模糊了单细胞和多细胞生命形式之间的区别。其中一些信号系统对人类健康也极其重要，因为它们调节细菌病原体的毒力决定因素。由于最近细菌细胞间通讯领域的研究激增，以及新发现的细菌在引发人类疾病中的作用，ASM 在 2001 年夏天主办了一次专门讨论细胞间信号传导的会议。这次会议受到了热烈欢迎与会者表示，ASM 致力于为该主题提供一个持续的场所，并将于 2004 年 7 月主办第二次会议。会议将在加拿大落基山脉阿尔伯塔省班夫举行。 NIH 慷慨支持了 ASM 主办的关于该主题的首届会议，并支持了许多研究细菌细胞间通讯的研究人员，并希望 NIH 能为即将举行的会议提供财政援助。