Advan Scintillator Structure for X-Ray Microtomography

用于 X 射线显微断层扫描的 Advan 闪烁体结构

• 批准号: 6540617
• 负责人: VIVEK V NAGARKAR
• 金额: $ 37.6万
• 依托单位: RADIATION MONITORING DEVICES, INC.
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-17 至 2003-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6540617
• 关键词: X ray; bioengineering /biomedical engineering; biomedical equipment development; bone imaging /visualization /scanning; cesium; charge coupled device camera; clinical biomedical equipment; computed axial tomography; digital imaging; image processing; printing; scintillation cameras; tomography

DESCRIPTION (Provided by Applicant): The availability of synchrotron x-ray radiation advanced micro-focused x-ray generators has sparked new developments in computed tomography (CT), giving rise to a new generation of x-ray microtomography (XMT) instrumentation. XMT carries the CT techniques to their limits in spatial resolution and contrast sensitivity. Thus, the ability to make precise x-ray attenuation measurements on ever-smaller volume elements is made possible by XMT. These advantages have been exploited by scientists in both medical and non-medical applications. Additionally, developments in detectors, computing technology, and 3D visualization have made XMT even more attractive as a research tool. Capabilities of current XMT scanners, however, are severely limited by the existing x-ray sensors. Using conventional sensors, there exists a problematic tradeoff between the thickness and spatial resolution due to lateral light spreading. Persistence of these sensors further limit the scanning speed. To address these issues, we propose to develop a novel scintillator to be incorporated into CCD based XMT systems. The new scintillator will suppress the lateral spread of scintillation light even when the structure is made very thick. For the x-ray energies typically used in XMl, this sensor will provide high resolution, high detection efficiency and fast scanning speed, allowing the full potential of XMT technique to be realized. PROPOSED COMMERCIAL APPLICATION: In addition to the application of microtomography, the proposed development of novel pixelized scintillator would find widespread use in instrumentation wherever high-resolution x-ray. imaging is used. The technology of micro-machining is adaptable to a wide range of sensors including solid-state detectors, thus opening an access to a wide x-ray imaging market which is currently estimated to be in hundreds of millions of dollars. They may be applied to digital mammography, non-destructive testing, diffraction instruments, and several other medical imaging systems.

描述（由申请人提供）：同步加速器 X 射线的可用性 辐射先进微聚焦X射线发生器引发新发展 计算机断层扫描 (CT) 领域，催生了新一代 X 射线 显微断层扫描（XMT）仪器。 XMT 将 CT 技术应用到他们的领域 空间分辨率和对比灵敏度的限制。因此，能够 对更小的体积元素进行精确的 X 射线衰减测量 XMT 使之成为可能。这些优点已被科学家们充分利用 医疗和非医疗应用。此外，发展 探测器、计算技术和 3D 可视化使 XMT 更加出色 作为一种有吸引力的研究工具。 然而，当前 XMT 扫描仪的功能受到以下因素的严重限制： 现有的 X 射线传感器。使用传统的传感器，存在一个问题 由于侧向光而导致的厚度和空间分辨率之间的权衡 传播。这些传感器的持续存在进一步限制了扫描速度。到 为了解决这些问题，我们建议开发一种新型闪烁体 纳入基于 CCD 的 XMT 系统。新的闪烁体将抑制 即使结构做得非常好，闪烁光也会横向传播 厚的。对于 XMl 中通常使用的 X 射线能量，该传感器将提供 分辨率高、检测效率高、扫描速度快，使 XMT 技术的全部潜力得以实现。 拟议的商业应用： 除了显微断层扫描的应用之外，所提议的新型像素化闪烁体的开发将在高分辨率 X 射线仪器中得到广泛应用。使用成像。微加工技术适用于包括固态探测器在内的各种传感器，从而打开了广阔的X射线成像市场的大门，目前该市场估计价值数亿美元。它们可应用于数字乳房X线摄影、无损检测、衍射仪器和其他几种医学成像系统。