NEURAL BASES OF PERCEPTUAL FILLING IN: VISUAL CORTEX

知觉填充的神经基础：视觉皮层

• 批准号: 6480915
• 负责人: MICHAEL SLOANE
• 金额: $ 15.58万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-01 至 2003-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6480915
• 关键词: bioengineering /biomedical engineering; biomedical resource; child (0-11); congenital disorders; female; human subject; magnetic resonance imaging; male; nervous system; proteins; technology /technique

Metabolic Lesions in Focal Epilepsy Studied by MRI and Spectroscopy (Whitaker Foundation) Introduction: Up to 20% of focal epilepsy patients (about 400,000 in the USA) fail to respond to anti-epileptic medication. Fewer than one-third of these refractory patients are currently considered candidates for the highly effective surgery to resect the seizure focus because the presurgical evaluation is costly, inaccurate, and often invasive (thus risky). It is also thought that seizures may induce secondary neuronal dysfunction in brain tissue remote from the primary seizure focus. Methods: Using quantitative MRSI (Core Project I) and MRI (Core Project IV) methods, determine the optimal combination of MR measures for localization of the epileptogenic seizure focus. Results: Early studies indicate that a combination of 1H MRSI and relaxometry is highly sensitive and specific. In patients whose seizures are eliminated by surgery, recovery of normal metabolism and MRI measures has been observed one year after surgery in tissue with secondary neuronal dysfunction detected before the surgery. Discussion: The high sensitivity and specificity of noninvasive MRSI and MRI for localization of the epileptogenic seizure focus could reduce the cost and risk of presurgical evaluation and could qualify more refractory patients for effective surgical treatment. When the head gradient coil and rapid imaging are implemented (Core Projects IV and II), then volumetry, diffusion, and perfusion measurements at 4.1T will be routinely included in the protocol. From this full MR protocol, an optimal combination will be determined.

通过 MRI 和 MRI 研究局灶性癫痫的代谢病变 光谱学（惠特克基金会） 简介：高达 20% 的局灶性癫痫患者（约 （美国有 400,000 人）对抗癫痫药物没有反应。 目前，这些难治性患者中不到三分之一 被认为是高效手术切除的候选者 癫痫焦点，因为术前评估费用昂贵， 不准确，而且常常是侵入性的（因此有风险）。 也有人认为 癫痫发作可能引起脑组织继发性神经元功能障碍 远离原发病灶。 方法：使用定量 MRSI（核心项目 I）和 MRI（核心项目 I） 项目IV)方法，确定MR措施的最优组合 用于定位癫痫发作病灶。 结果：早期研究表明 1H MRSI 的组合 松弛测量法具有高度的敏感性和特异性。 在患者中 癫痫发作可通过手术、恢复正常新陈代谢和 手术一年后，在组织中观察到 MRI 测量结果 手术前检测到继发性神经元功能障碍。 讨论：无创性的高敏感性和特异性 MRSI 和 MRI 可以定位癫痫发作病灶 降低术前评估的成本和风险，并可能获得资格 更为难治性患者提供有效的手术治疗。 当 实施头部梯度线圈和快速成像（核心项目 IV 和 II)，然后在 4.1T 下进行体积、扩散和灌注测量 将常规地包含在协议中。 从这个完整的MR 协议，将确定最佳组合。