Cardiovascular Chemoreflex-Baroreflex Interaction

心血管化学反射-压力反射相互作用

• 批准号: 6690031
• 负责人: John R. Halliwill
• 金额: $ 24.95万
• 依托单位: UNIVERSITY OF OREGON
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-01-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6690031
• 关键词: autonomic nervous system; baroreceptors; baroreflex; blood pressure; cardiovascular function; chemoreceptors; heart rate; human subject; hyperpnea; hypocapnia; hypoxia; neuroregulation; nitroferricyanide; phenylephrine

DESCRIPTION (provided by applicant): The primary focus of my research program is to understand how the autonomic nervous system regulates the human cardiovascular system. The overall goal of this grant application is to enhance understanding of how the peripheral and central chemoreflexes modify arterial baroreflex function in humans, focusing on muscle sympathetic nerve activity and heart rate. Chemoreflexes and baroreflexes play a major role in control of the cardiovascular system via the profound influences they exert on autonomic outflow. However, the interaction of these powerful reflex systems is not completely understood in humans. In this Context, the specific aims for this grant application are designed to address the following questions: 1) Does isocapnic hyperpnea alter arterial baroreflex function in humans? 2a) Does isocapnic hypoxia alter arterial baroreflex function in humans? 2b) Does the selective peripheral chemoreceptor stimulant almitrine mimic the effects of hypoxia on arterial baroreflex function in humans? 3) Does hyperoxic hypocapnia alter arterial baroreflex function in humans? Throughout this application, we exploit state-of-the-art methods and propose highly controlled studies in conscious human volunteers, probing questions raised by animal studies in this area. These studies will advance our understanding of basic cardiovascular regulation in humans and how it is modified by changes in chemoreflex stimulation. Further, these studies will provide a foundation of basic understanding that will be necessary to explain related pathophysiologies such as heart failure, COPD, and sleep apnea. By addressing these aims, we will extend insights that are now only available in animals to a poorly understood area of cardiovascular regulation in humans.

描述（由申请人提供）：我的研究计划的主要重点 是要了解自主神经系统如何调节人类 心血管系统。该赠款申请的总体目标是增强 了解周围和中央化学反流如何修饰动脉 人类的BaroreFlex功能，专注于肌肉交感神经活动 和心率。化学反射和压力反射在控制中起着重要作用 他们对自主神经的深刻影响的心血管系统 外流。但是，这些功能强大的反射系统的相互作用不是 在人类中完全理解。在这种情况下，具体的目的是 授予申请旨在解决以下问题：1） 异含量蜂巢改变人类的动脉压力反射功能？ 2a） 异含量低氧改变了人类的动脉压力反射功能？ 2b）做 选择性外围化学感受器刺激性醛固星模仿 人类动脉压力反射功能缺氧？ 3）高氧化症 改变人类的动脉压力反射功能？在整个应用程序中，我们 利用最先进的方法，并提出了高度控制的研究 有意识的人类志愿者，探测动物研究提出的问题 区域。这些研究将提高我们对基本心血管的理解 人类的调节及其如何通过化学反射的变化对其进行修改 刺激。此外，这些研究将为基础提供基础 理解这是解释相关病理生理的必要条件 作为心力衰竭，COPD和睡眠呼吸暂停。通过解决这些目标，我们将 扩展目前仅在动物中可用的见解到一个知之甚少 人类心血管调节区域。