DEVELOPMENT OF ADVANCED CHEMICAL SHIFT IMAGING (CSI) TECHNIQUES

先进化学位移成像 (CSI) 技术的发展

• 批准号: 6501426
• 负责人: ODED GONEN
• 金额: $ 18.37万
• 依托单位: FOX CHASE CANCER CENTER
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-19 至 2002-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6501426
• 关键词: bioimaging /biomedical imaging; brain neoplasms; clinical research; diagnosis design /evaluation; head /neck neoplasm; human subject; image enhancement; method development; neoplasm /cancer diagnosis; nuclear magnetic resonance spectroscopy; squamous cell carcinoma

Chemical Shift Imaging (CSI) is the method of choice for in vivo localized spectroscopy. However, several persistent obstacles still remain in its application to nuclei other than protons, specifically 31P and 19F CSI proposed in projects of this application. First, the sensitivity is low. Second and several consequents, the measurements are long, thus, only one nucleus can be observed in a clinical session, even if information from another is significant and sought. Third, the current Fourier reconstruction methods, widely used because of their computational convenience and simplicity, result in an artifact that intermixes signal from one voxel, with its its neighbors. This artifact, known as A voxel bleed, leads to spectral-contamination and impacts CSI in general. We propose to address these difficulties from three angles. First, to use polarization transfer techniques from 1H to the less sensitive 31P to increase the signal of the latter and to be used in project II. Second, to develop simultaneous acquisition techniques that will allow 1H decoupled 31P and 19F CSI acquisition during a single clinical examination. Third, to develop non-Fourier transform techniques that, using prior knowledge from the proton images, will improve the accuracy of CSI reconstruction.

化学位移成像 (CSI) 是体内研究的首选方法 局域光谱学。 然而，仍然存在一些持续存在的障碍 仍适用于质子以外的原子核，特别是 31P 以及本申请项目中提出的19F CSI。 首先， 灵敏度低。 第二个也是几个后果，测量 很长，因此，在临床会议中只能观察到一个细胞核， 即使来自他人的信息很重要并且是寻求的。 第三， 当前的傅立叶重建方法由于其优点而被广泛使用 计算的便利性和简单性，导致了一个工件 将来自一个体素的信号与其邻居的信号混合。 这件神器， 称为体素出血，会导致光谱污染并影响 CSI 一般来说。 我们建议从三个角度解决这些困难。 一、使用 偏振传输技术从 1H 到不太敏感的 31P 增强后者的信号，用于项目二。 其次，为了 开发同步采集技术，允许 1H 解耦 在单次临床检查期间采集 31P 和 19F CSI。 第三， 开发非傅里叶变换技术，利用先验知识 质子图像，将提高 CSI 的准确性 重建。