Microneedle Array for Catheter Drug Delivery

用于导管药物输送的微针阵列

• 批准号: 6734397
• 负责人: SHUVO ROY
• 金额: $ 22.35万
• 依托单位: CLEVELAND CLINIC FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-12 至 2004-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6734397
• 关键词: animal tissue; bioengineering /biomedical engineering; biomedical equipment development; cardiovascular disorder therapy; catheterization; clinical biomedical equipment; computer simulation; coronary artery; drug delivery systems; fluorescent dye /probe; heart catheterization; microelectrodes; microinjections; miniature biomedical equipment; silicon

DESCRIPTION (provided by applicant): The ultimate goal of this project is the development of a catheter that can inject drugs directly into the wall of the coronary artery to prevent restenosis after angioplasty. MEMS (microelectromechanical systems) technology will be used to prototype miniature hollow needles from silicon substrates. Microneedle arrays will be integrated with low profile catheter delivery systems for transport to and from the deployment site within arteries. Finite element modeling will be used to generate robust needle designs, which will be subsequently fabricated using deep reactive ion etching and wet anisotropic etching of silicon. Different microneedle geometries and array layouts will be fabricated and evaluated for mechanical strength and penetration characteristics into filleted rabbit lilac and porcine coronary arteries. Two low profile catheter delivery systems will be developed to transport the microneedle array to the coronary artery. One approach will rely on a low profile balloon to house the microneedle array inside molded pockets within the balloon. The other approach will investigate a novel suction catheter that would house the microneedle during transport. Once at the deployment site within the artery, suction would be applied via a syringe to pull the vascular wall towards the catheter and force the microneedles into the tissue. Fluid delivery will be demonstrated by injecting Evan's Blue dye into the arterial wall. Experiments and computer modeling will be conducted to optimize the microneedle geometry and array layout for penetration and fluid delivery. Results of this R21 project will establish the feasibility for further development of microneedles for local drug delivery catheters that could be used to investigate the efficacy and delivery characteristics of anti-restenosis therapy delivered directly into the vascular wall.

描述（申请人提供）：该项目的最终目标是开发一种可以将药物直接注入冠状动脉壁的导管，以防止血管成形术后再狭窄。 MEMS（微机电系统）技术将用于从硅基板制作微型空心针原型。微针阵列将与薄型导管输送系统集成，用于在动脉内的部署部位之间进行运输。有限元建模将用于生成稳健的针设计，随后将使用深反应离子蚀刻和硅湿法各向异性蚀刻来制造。将制造不同的微针几何形状和阵列布局，并评估机械强度和对兔紫丁香和猪冠状动脉的穿透特性。将开发两种低轮廓导管输送系统，用于将微针阵列输送到冠状动脉。一种方法将依靠低轮廓气球将微针阵列容纳在气球内的模制口袋内。另一种方法将研究一种新型抽吸导管，该导管可在运输过程中容纳微针。一旦到达动脉内的部署位置，将通过注射器施加抽吸，将血管壁拉向导管，并将微针推入组织中。将通过将埃文蓝染料注入动脉壁来演示液体输送。将进行实验和计算机建模，以优化微针的几何形状和阵列布局，以实现渗透和流体输送。该 R21 项目的结果将为进一步开发用于局部药物输送导管的微针建立可行性，该微针可用于研究直接输送到血管壁的抗再狭窄治疗的功效和输送特性。