AMORPHOUS CALCIUM PHOSPHATE BASED DENTAL MATERIALS

无定形磷酸钙牙科材料

• 批准号: 6727811
• 负责人: DRAGO SKRTIC
• 金额: $ 29.45万
• 依托单位: AMERICAN DENTAL ASSOCIATION FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-03-01 至 2008-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6727811
• 关键词: X ray crystallography; amorphous solid; biomaterial development /preparation; biomaterial evaluation; biomaterial interface interaction; calcium phosphate; cations; chemical stability; clinical research; composite resins; dental adhesive /sealant; dental structure; human tissue; infrared spectrometry; interferometry; microradiography; nuclear magnetic resonance spectroscopy; polymers; restorative dentistry; scanning electron microscopy; thermodynamics

DESCRIPTION: Our research for the last 4 years (grant DE13169) with amorphous calcium phosphate (ACP)-based Dental composites has resulted in biocompatible composites with demineralizing ability, moderately improved mechanical strength and adhesiveness to tooth structures. Nevertheless, current ACP composites have less than optimal filler/matrix cohesion and adsorb water excessively. These factors can have adverse effects on the physicochemical and mechanical properties of these materials, and thereby limit their clinical applicability. This application outlines our research for improving the physical and antidemineralizing/ demineralizing properties of ACP composites to where they can be used in a broad variety of applications where caries control and reversal is desired. The main objectives of this application are: [1] to further study structure/composition/property relationships of ACP fillers to develop strategies that better control the dispersion of ACP in the polymer matrix, [2] investigate intracomposite filler/organic matrix interactions and composite/tooth interactions to determine the mechanisms that control mineral redeposition from these composites and [3] to extend the utility of ACP to remineralizing orthodontic adhesives. To accomplish these objectives we propose to: (a) assess the role of foreign ions/molecules in controlling the particle size, compositional and structural properties of ACP fillers while maintaining chemical stability to prevent premature intra-composite conversion to non-ion releasing crystalline apatite, (b) elucidate interfacial coupling and polymer grafting reactions as a route to enhance the interfacial strength between the ACP and the polymeric matrix, and (c) evaluate ACP-composites designed for orthodontic applications for their in vitro remineralization ability and bonding properties. The proposed research is expected to provide the new experimental evidence needed to advance our understanding of the fundamental mechanisms that govern dissolution/reprecipitation of the ACP filler and, consequently, the demineralizing ability of ACP-based Dental materials. The proposed studies should lead to the design of ACP composites for a variety of Dental applications and the formulation of a prototype orthodontic cement that is suitable for clinical evaluation.

描述：我们过去 4 年（授予 DE13169）对基于无定形磷酸钙 (ACP) 的牙科复合材料的研究已经产生了具有脱矿能力、适度改善机械强度和对牙齿结构的粘附性的生物相容性复合材料。然而，目前的 ACP 复合材料的填料/基体内聚力不够理想，并且会过度吸水。这些因素会对这些材料的物理化学和机械性能产生不利影响，从而限制其临床应用。该应用概述了我们的研究，旨在改善 ACP 复合材料的物理和抗脱矿/脱矿性能，使其可用于需要龋齿控制和逆转的各种应用。 该应用的主要目标是：[1] 进一步研究 ACP 填料的结构/组成/性能关系，以制定更好地控制 ACP 在聚合物基体中分散的策略，[2] 研究复合材料内部填料/有机基体相互作用和复合材料/牙齿相互作用，以确定控制这些复合材料中矿物质再沉积的机制，并 [3] 将 ACP 的用途扩展到再矿化正畸粘合剂。为了实现这些目标，我们建议：（a）评估外来离子/分子在控制 ACP 填料的粒径、成分和结构特性方面的作用，同时保持化学稳定性，以防止复合材料内部过早转化为非离子释放结晶磷灰石，（b）阐明界面偶联和聚合物接枝反应作为增强 ACP 和聚合物基质之间界面强度的途径，以及（c）评估为正畸应用设计的 ACP 复合材料它们的体外再矿化能力和粘合特性。拟议的研究预计将提供新的实验证据，以增进我们对控制 ACP 填料溶解/再沉淀的基本机制的理解，从而了解 ACP 牙科材料的脱矿能力。拟议的研究应该能够设计出适用于各种牙科应用的 ACP 复合材料，以及适合临床评估的原型正畸水泥的配方。