AMORPHOUS CALCIUM PHOSPHATE BASED DENTAL MATERIALS

无定形磷酸钙牙科材料

• 批准号: 6727811
• 负责人: DRAGO SKRTIC
• 金额: $ 29.45万
• 依托单位: AMERICAN DENTAL ASSOCIATION FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-03-01 至 2008-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6727811
• 关键词: X ray crystallography; amorphous solid; biomaterial development /preparation; biomaterial evaluation; biomaterial interface interaction; calcium phosphate; cations; chemical stability; clinical research; composite resins; dental adhesive /sealant; dental structure; human tissue; infrared spectrometry; interferometry; microradiography; nuclear magnetic resonance spectroscopy; polymers; restorative dentistry; scanning electron microscopy; thermodynamics; X ray crystallography; amorphous solid; biomaterial development /preparation; biomaterial evaluation; biomaterial interface interaction; calcium phosphate; cations; chemical stability; clinical research; composite resins; dental adhesive /sealant; dental structure; human tissue; infrared spectrometry; interferometry; microradiography; nuclear magnetic resonance spectroscopy; polymers; restorative dentistry; scanning electron microscopy; thermodynamics

DESCRIPTION: Our research for the last 4 years (grant DE13169) with amorphous calcium phosphate (ACP)-based Dental composites has resulted in biocompatible composites with demineralizing ability, moderately improved mechanical strength and adhesiveness to tooth structures. Nevertheless, current ACP composites have less than optimal filler/matrix cohesion and adsorb water excessively. These factors can have adverse effects on the physicochemical and mechanical properties of these materials, and thereby limit their clinical applicability. This application outlines our research for improving the physical and antidemineralizing/ demineralizing properties of ACP composites to where they can be used in a broad variety of applications where caries control and reversal is desired. The main objectives of this application are: [1] to further study structure/composition/property relationships of ACP fillers to develop strategies that better control the dispersion of ACP in the polymer matrix, [2] investigate intracomposite filler/organic matrix interactions and composite/tooth interactions to determine the mechanisms that control mineral redeposition from these composites and [3] to extend the utility of ACP to remineralizing orthodontic adhesives. To accomplish these objectives we propose to: (a) assess the role of foreign ions/molecules in controlling the particle size, compositional and structural properties of ACP fillers while maintaining chemical stability to prevent premature intra-composite conversion to non-ion releasing crystalline apatite, (b) elucidate interfacial coupling and polymer grafting reactions as a route to enhance the interfacial strength between the ACP and the polymeric matrix, and (c) evaluate ACP-composites designed for orthodontic applications for their in vitro remineralization ability and bonding properties. The proposed research is expected to provide the new experimental evidence needed to advance our understanding of the fundamental mechanisms that govern dissolution/reprecipitation of the ACP filler and, consequently, the demineralizing ability of ACP-based Dental materials. The proposed studies should lead to the design of ACP composites for a variety of Dental applications and the formulation of a prototype orthodontic cement that is suitable for clinical evaluation.

描述：我们在过去4年中的研究（Grant DE13169）具有非晶态磷酸钙（ACP）的牙科复合材料，导致具有脱矿物化能力的生物相容性复合材料，适度提高了机械强度和对牙齿结构的粘附力。然而，当前的ACP复合材料的含量小于最佳的填充/基质内聚和吸附水。这些因素可能会对这些材料的理化和机械性能产生不利影响，从而限制其临床适用性。该应用程序概述了我们的研究，用于改善ACP复合材料的物理和抗矿物化/去矿化特性，以在需要龋齿控制和逆转的广泛应用中使用。 该应用程序的主要目标是：[1]进一步研究ACP填充剂的结构/组成/财产关系，以制定更好地控制聚合物基质中ACP分散的策略，[2]研究复合填充剂/有机基质相互作用和复合/牙齿相互作用，以确定从这些组合和act seption composition的机制，以扩展这些复合物和act [3]的机制[3]粘合剂。 To accomplish these objectives we propose to: (a) assess the role of foreign ions/molecules in controlling the particle size, compositional and structural properties of ACP fillers while maintaining chemical stability to prevent premature intra-composite conversion to non-ion releasing crystalline apatite, (b) elucidate interfacial coupling and polymer grafting reactions as a route to enhance the interfacial strength between the ACP and the聚合物基质和（c）评估用于正畸应用的ACP复合材料，用于其体外回忆能力和键合特性。预计拟议的研究将提供新的实验证据，以促进我们对管理ACP填充物溶解/重新沉淀的基本机制的理解，从而促进我们对基于ACP的牙科材料的非矿物化能力的理解。拟议的研究应导致为多种牙齿应用的ACP复合材料设计，并制定适合临床评估的原型正畸水泥。