Conference Proposal: Ion Channel Regulation

会议提案：离子通道调控

• 批准号: 6597283
• 负责人: SANDRA ROSSIE
• 金额: $ 1.1万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-06-15 至 2004-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6597283
• 关键词: G protein; ions; meeting /conference /symposium; membrane channels; phosphorylation; second messengers; travel

DESCRIPTION (provided by applicant): This is an application for partial support of the inaugural FASEB summer conference on Ion Channel Regulation to be held June 14-19, 2003 at the Omni Resort in Tucson, AZ. Major topics to be covered include regulation of channel expression, distribution and activity by signaling mechanisms involving G protein cascades, second messengers, protein phosphorylation, cytoskeleton and signaling complex adapter proteins. Novel channel functions and signaling pathways will also be presented. Speakers will include prominent scientists, both established and emerging, who have made important discoveries in the past 18 months, some still unpublished. In addition to speaking, senior women will chair most sessions. Approximately 145 additional participants will be selected predominantly from pre-and postdoctoral trainees and young faculty, and priority will be given to those who present abstracts or have been historically underrepresented in science. A novel feature of this meeting will be the inclusion of discussion sessions for trainees to speak informally with speakers. Requested funds will be used to provide travel awards for junior investigators and to partially defray the costs of speakers' attendance. This meeting will alternate with and complement the biennial Gordon Conference on ion channels, which focuses on the biophysical properties of ion channel proteins, particularly in electrically excitable cells. Historically ion channel regulation research has been too biochemical for channel meetings, and too biophysical for signaling meetings. This conference is designed to bring together investigators from many disciplines, biochemistry, biophysics, cell and molecular biology, physiology and neuroscience. Many recent advances have occurred in ion channel regulation research, making this a timely and important conference topic in its own right. New structural families of ion channels have been identified that respond to novel signals and serve non-traditional cellular functions in development, in aging and in immune responses. Ion channel mutations have also been identified in human diseases of the nervous, endocrine, cardiac, vascular and renal and systems. It is expected that disruption of the signaling pathways that regulate channel activity will have similar deleterious consequences for human health, so successful prevention and treatment of these diseases will require a clearer understanding of the molecular mechanisms involved.

描述（由申请人提供）： 这是对将于 2003 年 6 月 14 日至 19 日在亚利桑那州图森 Omni Resort 举行的首届 FASEB 离子通道调节夏季会议的部分支持的申请。涵盖的主要主题包括通过涉及 G 蛋白级联、第二信使、蛋白磷酸化、细胞骨架和信号复合衔接蛋白的信号传导机制调节通道表达、分布和活性。还将介绍新的通道功能和信号传导途径。演讲者将包括知名科学家和新兴科学家，他们在过去 18 个月中取得了重要发现，其中一些尚未发表。除了发言外，高级女性还将主持大部分会议。大约 145 名额外参与者将主要从博士前和博士后实习生以及年轻教师中选出，并将优先考虑那些提交摘要或历史上在科学领域代表性不足的人。本次会议的一个新颖特点是包括让学员与演讲者进行非正式交谈的讨论会。申请的资金将用于为初级研究人员提供旅费奖励，并部分支付演讲者出席的费用。这次会议将与两年一度的戈登离子通道会议交替进行并对其进行补充，戈登会议重点关注离子通道蛋白的生物物理特性，特别是在可电兴奋的细胞中。从历史上看，离子通道调节研究对于通道会议来说过于生化，对于信号会议来说又过于生物物理。这次会议旨在汇集来自生物化学、生物物理学、细胞和分子生物学、生理学和神经科学等多个学科的研究人员。离子通道调节研究最近取得了许多进展，这使其本身成为一个及时而重要的会议主题。已经确定了新的离子通道结构家族，它们对新信号做出反应，并在发育、衰老和免疫反应中发挥非传统细胞功能。在人类神经、内分泌、心脏、血管和肾脏及系统疾病中也发现了离子通道突变。预计调节通道活动的信号通路的破坏将对人类健康产生类似的有害后果，因此成功预防和治疗这些疾病将需要更清楚地了解所涉及的分子机制。