Vestibular Responses of Rostral Fastigial Neurons

头端顶神经元的前庭反应

基本信息

批准号：
6739497
负责人：
Aasef G Shaikh
金额：
$ 4.99万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-09-01 至 2004-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6739497
关键词：
Macaca mulatta cell population study cerebellar nuclei electrophysiology eye movements gravity head movements neurophysiology otocyst /otolith postdoctoral investigator space perception vestibular nuclei

项目摘要

DESCRIPTION (provided by applicant): Accurate awareness of spatial orientation, which results from complex multidimensional interactions of sensory signals originating from multiple sources and different coordinate systems, is fundamental in maintaining posture as well as ongoing voluntary activities. Signals originating from otolith, semicircular canal, and muscle proprioceptive receptors are examples of such sensory cues required by the CNS to execute reflex control of body posture and movement. The deep cerebellar nuclei are some of the known sites of signal convergence from vestibular and proprioceptive systems. The aims of the proposed project are threefold: (1) To investigate vestibular convergence patterns in the rostral fastigial nucleus (rFN) vestibular only neurons using combinations of 3D rotations and translations (2) To investigate if some of the rFN neurons selectively encode translations and ignore changes in head orientations in relation to gravity. This project aims to quantitatively test this hypothesis using protocols with combinations of translational and tilt motion stimuli. (3) To investigate the coordinate system of encoding translational motion. Specifically, we have hypothesized that there exist rFN neurons that encode translational motion in body coordinates. Using a variety of combinations of vestibular stimulations and single unit electrophysiology, numerous relationships will be examined. The results are important in improving our understanding of the functional role of the deep cerebellar nuclei and of the significance of otolith/canal convergence in the central vestibular system.

描述（由申请人提供）：对空间方位的准确认识是源自多个来源和不同坐标系的感觉信号的复杂多维相互作用的结果，对于保持姿势以及正在进行的自愿活动至关重要。源自耳石、半规管和肌肉本体感受器的信号是中枢神经系统执行身体姿势和运动反射控制所需的感觉线索的例子。小脑深部核团是前庭和本体感觉系统信号汇聚的一些已知位点。该项目的目标有三个：（1）使用 3D 旋转和平移的组合来研究头顶核（rFN）仅前庭神经元的前庭收敛模式（2）研究某些 rFN 神经元是否选择性地编码平移和忽略头部方向相对于重力的变化。该项目旨在使用平移运动刺激和倾斜运动刺激组合的协议来定量测试这一假设。 (3)研究编码平移运动的坐标系。具体来说，我们假设存在 rFN 神经元，它们编码身体坐标中的平移运动。使用前庭刺激和单个单元电生理学的各种组合，将检查许多关系。这些结果对于提高我们对小脑深部核团的功能作用以及中央前庭系统中耳石/耳管会聚的重要性的理解非常重要。