Sleep Heart Health Study

睡眠心脏健康研究

• 批准号: 6820458
• 负责人: HELAINE E. RESNICK
• 金额: $ 24.32万
• 依托单位: MISSOURI BREAKS RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-30 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6820458
• 关键词: cardiovascular disorder epidemiology; cardiovascular disorder risk; clinical research; cooperative study; coronary disorder; data collection methodology /evaluation; functional ability; human morbidity; human mortality; human subject; hypertension; information dissemination; longitudinal human study; polysomnography; quality of life; respiratory airflow disorder; sleep apnea; sleep disorders; stroke

DESCRIPTION (provided by applicant): The prevalence of sleep disordered breathing (SDB) in middle aged persons in the general population is estimated to be 4 percent in men and 2 percent in women with higher rates observed in the elderly. Accumulating evidence from retrospective and cross-sectional studies suggest that SDB is associated with the presence of cardiovascular and cerebrovascular disease (CVD) and consequent increased mortality and morbidity. However, there is little prospective data indicating whether SDB is an independent risk factor for the development of DVD. The Sleep Heart Health Study (SHHS) is a longitudinal multi-center cohort study that was started in 1994 to determine the cardiovascular consequences of SDB. Initially, SHHS recruited 6,441 participants (1996-98) to undergo in-home polysomnography (PSG) and acquisition of other CVD and sleep-related data. A repeat examination with repeat PSG (2001-2003) has just been completed. Mortality and morbidity follow-up is ongoing, but event rates have been insufficient to provide stable estimates of the effect of SDB on incident CVD and mortality. Additionally, a unique resource of SHHS is its archive of approximately 10,000 PSGs, associated scoring and clinical covariate data. Providing the scientific community access to this data has always been an important goal of SHHS and has the potential to realize significant benefits in collaborative research ranging from novel methods of signal processing to identifying unique epidemiologic associations. Therefore, this application proposes additional mortality and morbidity follow-up of the SHHS cohort, continuation of longitudinal and cross-sectional data analyses focused on SDB as a risk factor for cardiovascular events and hypertension, and development of an infrastructure to facilitate access by the general scientific community to the SHHS PSG archive. These goals will be achieved by accomplishing the following specific aims: 1) to continue follow-up of the SHHS cohort in order to assess SDB as a risk factor for new-onset hypertension and new-onset and recurrent cardiovascular disease; 2) to characterize the natural history of SDB and determine how change in RDI is related to risk for interim and incident CVD events; 3) to characterize the relationship between SDB and SDB progression with quality of life, daytime sleepiness and motor vehicle accidents; 4) to use the PSG data as well as previous collected risk factor data from parent cohorts to develop a clinically and epidemiologically applicable model of risk relating to SDB; and 5) to develop an infrastructure to facilitate data sharing, collaborative analysis and dissemination of data analytic tools and research findings to the scientific community. Accomplishing these goals will provide important information concerning the public health impact of SDB.

描述（由申请人提供）：一般人群中年人睡眠呼吸障碍 (SDB) 的患病率估计男性为 4%，女性为 2%，老年人中的患病率更高。回顾性和横断面研究积累的证据表明，SDB 与心脑血管疾病 (CVD) 的存在以及随之而来的死亡率和发病率增加有关。然而，很少有前瞻性数据表明SDB是否是DVD发展的独立危险因素。睡眠心脏健康研究 (SHHS) 是一项纵向多中心队列研究，于 1994 年开始，旨在确定 SDB 对心血管的影响。最初，SHHS 招募了 6,441 名参与者（1996-98 年）进行家庭多导睡眠图 (PSG) 并获取其他 CVD 和睡眠相关数据。与重复 PSG（2001-2003）的重复检查刚刚完成。死亡率和发病率的随访正在进行中，但事件发生率不足以提供 SDB 对 CVD 事件和死亡率影响的稳定估计。此外，SHHS 的一个独特资源是其大约 10,000 个 PSG、相关评分和临床协变量数据的档案。为科学界提供这些数据一直是 SHHS 的一个重要目标，并且有可能在从信号处理的新方法到识别独特的流行病学关联等合作研究中实现显着的效益。因此，本申请建议对 SHHS 队列进行额外的死亡率和发病率随访，继续针对 SDB 作为心血管事件和高血压的危险因素进行纵向和横断面数据分析，并开发基础设施以方便一般人获取科学界到 SHHS PSG 档案。这些目标将通过实现以下具体目标来实现：1）继续对 SHHS 队列进行随访，以评估 SDB 作为新发高血压以及新发和复发性心血管疾病的危险因素； 2) 描述 SDB 的自然史并确定 RDI 的变化与临时和偶发 CVD 事件风险的关系； 3）描述SDB和SDB进展与生活质量、白天嗜睡和机动车事故之间的关系； 4) 使用PSG数据以及之前从父母队列中收集的风险因素数据来开发与SDB相关的临床和流行病学适用的风险模型； 5) 开发基础设施，以促进数据共享、协作分析以及向科学界传播数据分析工具和研究成果。实现这些目标将提供有关 SDB 对公共卫生影响的重要信息。